{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T18:51:29Z","timestamp":1780685489177,"version":"3.54.1"},"reference-count":81,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Wnt signaling is a highly conserved pathway in evolution which controls important processes such as cell proliferation, differentiation and migration, both in the embryo and in the adult. Dysregulation of this pathway can favor the development of different types of cancer, such as acute myeloid leukemia and other hematological malignancies. Overactivation of this pathway may promote the transformation of pre-leukemic stem cells into acute myeloid leukemia stem cells, as well as the maintenance of their quiescent state, which confers them with self-renewal and chemoresistance capacity, favoring relapse of the disease. Although this pathway participates in the regulation of normal hematopoiesis, its requirements seem to be greater in the leukemic stem cell population. In this review, we explore the possible therapeutic targeting of Wnt to eradicate the LSCs of AML.<\/jats:p>","DOI":"10.3390\/biology12050683","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:24:32Z","timestamp":1683257072000},"page":"683","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Understanding the Wnt Signaling Pathway in Acute Myeloid Leukemia Stem Cells: A Feasible Key against Relapses"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-1193","authenticated-orcid":false,"given":"Daniel","family":"L\u00e1inez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Experimental Hematology, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid, Avenida Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9766-5726","authenticated-orcid":false,"given":"Ana Bel\u00e9n","family":"Alonso-Aguado","sequence":"additional","affiliation":[{"name":"Experimental Hematology, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid, Avenida Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-5912","authenticated-orcid":false,"given":"Juan Manuel","family":"Alonso-Dominguez","sequence":"additional","affiliation":[{"name":"Experimental Hematology, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid, Avenida Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"},{"name":"Hematology Department, Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Avenida Reyes Cat\u00f3licos 2, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th Edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic Neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating Morphologic, Clinical, and Genomic Data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","article-title":"Mutations Affecting Segment Number and Polarity in Drosophila","volume":"287","author":"Wieschaus","year":"1980","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(87)90038-9","article-title":"The Drosophila Homolog of the Mouse Mammary Oncogene Int-1 Is Identical to the Segment Polarity Gene Wingless","volume":"50","author":"Rijsewijk","year":"1987","journal-title":"Cell"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/0092-8674(88)90220-6","article-title":"Expression of the Int-1 Gene in Transgenic Mice Is Associated with Mammary Gland Hyperplasia and Adenocarcinomas in Male and Female Mice","volume":"55","author":"Tsukamoto","year":"1988","journal-title":"Cell"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0092-8674(89)90506-0","article-title":"Ectopic Expression of the Proto-Oncogene Int-1 in Xenopus Embryos Leads to Duplication of the Embryonic Axis","volume":"58","author":"McMahon","year":"1989","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1651563","article-title":"Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients","volume":"253","author":"Nishisho","year":"1991","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.8259518","article-title":"Association of the APC Gene Product with Beta-Catenin","volume":"262","author":"Rubinfeld","year":"1993","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.8259519","article-title":"Association of the APC Tumor Suppressor Protein with Catenins","volume":"262","author":"Su","year":"1993","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/ncb2574","article-title":"Active Wnt Proteins Are Secreted on Exosomes","volume":"14","author":"Gross","year":"2012","journal-title":"Nat. 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