{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:04:52Z","timestamp":1791720292297,"version":"4.3.4"},"reference-count":91,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Universitaria San Pablo CEU, Microbiology SAI, 259 RedLab Madrid"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The emergence of antibiotic resistance (AR) poses a threat to the \u201cOne Health\u201d approach. Likewise, mercury (Hg) pollution is a serious environmental and public health problem. Its ability to biomagnify through trophic levels induces numerous pathologies in humans. As well, it is known that Hg-resistance genes and AR genes are co-selected. The use of plant-growth-promoting bacteria (PGPB) can improve plant adaptation, decontamination of toxic compounds and control of AR dispersal. The cenoantibiogram, a technique that allows estimating the minimum inhibitory concentration (MIC) of a microbial community, has been postulated as a tool to effectively evaluate the evolution of a soil. The present study uses the metagenomics of 16S rRNA gene amplicons to understand the distribution of the microbial soil community prior to bacterial inoculation, and the cenoantibiogram technique to evaluate the ability of four PGPB and their consortia to minimize antibiotic resistance in the rhizosphere of Lupinus albus var. Orden Dorado grown in Hg-contaminated soils. Results showed that the addition of A1 strain (Brevibacterium frigoritolerans) and its consortia with A2, B1 and B2 strains reduced the edaphic community\u00b4s MIC against cephalosporins, ertapenem and tigecycline. The metagenomic study revealed that the high MIC of non-inoculated soils could be explained by the bacteria which belong to the detected taxa,. showing a high prevalence of Proteobacteria, Cyanobacteria and Actinobacteria.<\/jats:p>","DOI":"10.3390\/biology12060801","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T02:39:47Z","timestamp":1685587187000},"page":"801","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Reduced Antibiotic Resistance in the Rhizosphere of Lupinus albus in Mercury-Contaminated Soil Mediated by the Addition of PGPB"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8221-4584","authenticated-orcid":false,"given":"Daniel","family":"Gonz\u00e1lez-Reguero","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science and Health, San Pablo University, CEU Universities, Ctra. Boadilla del Monte Km 5.300, 28668 Boadilla del Monte, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-372X","authenticated-orcid":false,"given":"Marina","family":"Robas-Mora","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science and Health, San Pablo University, CEU Universities, Ctra. Boadilla del Monte Km 5.300, 28668 Boadilla del Monte, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-0529","authenticated-orcid":false,"given":"Vanesa M.","family":"Fern\u00e1ndez-Pastrana","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science and Health, San Pablo University, CEU Universities, Ctra. Boadilla del Monte Km 5.300, 28668 Boadilla del Monte, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2024-5457","authenticated-orcid":false,"given":"Agust\u00edn","family":"Probanza-Lobo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science and Health, San Pablo University, CEU Universities, Ctra. Boadilla del Monte Km 5.300, 28668 Boadilla del Monte, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0305-6889","authenticated-orcid":false,"given":"Pedro Antonio","family":"Jim\u00e9nez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science and Health, San Pablo University, CEU Universities, Ctra. Boadilla del Monte Km 5.300, 28668 Boadilla del Monte, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s40168-018-0572-7","article-title":"Consistent Responses of Soil Microbial Taxonomic and Functional Attributes to Mercury Pollution across China","volume":"6","author":"Liu","year":"2018","journal-title":"Microbiome"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13280-017-1006-7","article-title":"Challenges and Opportunities for Managing Aquatic Mercury Pollution in Altered Landscapes","volume":"47","author":"Eckley","year":"2018","journal-title":"Ambio"},{"key":"ref_3","first-page":"511","article-title":"Insights into the Potential Role of Mercury in Alzheimer\u2019s Disease","volume":"67","author":"Tinkov","year":"2019","journal-title":"J. Mol. 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