{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:49:34Z","timestamp":1790905774229,"version":"4.1.0"},"reference-count":100,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Institutes of Health\u2014National Cancer Institute","award":["R00 CA245030 (D.B.)"],"award-info":[{"award-number":["R00 CA245030 (D.B.)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.<\/jats:p>","DOI":"10.3390\/biology12070922","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T01:53:57Z","timestamp":1688003637000},"page":"922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5262-0883","authenticated-orcid":false,"given":"Karthik","family":"Gourishetti","sequence":"first","affiliation":[{"name":"Biotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA"},{"name":"Department of Pathology, Microbiology, and Immunology, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5381","authenticated-orcid":false,"given":"Vignesh","family":"Balaji Easwaran","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssef","family":"Mostakim","sequence":"additional","affiliation":[{"name":"Biotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA"},{"name":"Department of Pathology, Microbiology, and Immunology, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA"},{"name":"College of Arts and Sciences, University of South Carolina, Columbia, SC 29208, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2017-9533","authenticated-orcid":false,"given":"K. Sreedhara","family":"Ranganath Pai","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4142-5518","authenticated-orcid":false,"given":"Deepak","family":"Bhere","sequence":"additional","affiliation":[{"name":"Biotherapeutics Laboratory, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA"},{"name":"Department of Pathology, Microbiology, and Immunology, School of Medicine Columbia, University of South Carolina, Columbia, SC 29209, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fimmu.2016.00406","article-title":"miRNA-124 in Immune System and Immune Disorders","volume":"7","author":"Qin","year":"2016","journal-title":"Front. 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