{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:26:59Z","timestamp":1793986019534,"version":"4.8.0"},"reference-count":79,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science Technology, Taiwan","award":["108-2313-B-033-001-MY3"],"award-info":[{"award-number":["108-2313-B-033-001-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Fenpropathrin, a pyrethroid insecticide, has been widely used for many years in agricultural fields. It works by disturbing the voltage-gated sodium channel, leading to paralysis and the death of the target animal. While past studies have focused on neurodegeneration following fenpropathrin poisoning in humans, relatively few pieces of research have examined its effect on other peripheral organs. This study successfully investigated the potential toxicity of fenpropathrin on the cardiovascular system using zebrafish as an animal model. Zebrafish larvae exposed to varying doses of fenpropathrin underwent an evaluation of cardiac physiology by measuring the heart rate, stroke volume, cardiac output, and shortening fraction. The blood flow velocity and the dorsal aorta diameter were also measured to assess the impact of fenpropathrin exposure on the vascular system. Furthermore, molecular docking was performed to evaluate the pesticide binding affinity to various proteins associated with the cardiovascular system, revealing the potential mechanism of the fenpropathrin cardiotoxic effect. The findings demonstrated a significant dose-dependent increase in the heart rate stroke volume, cardiac output, shortening fraction, and ejection fraction of zebrafish larvae after 24 h of acute treatment with fenpropathrin. Additionally, zebrafish treated at a concentration of 1 ppm exhibited significantly larger blood vessels in diameter and an increased blood flow velocity compared to the control group. According to molecular docking, fenpropathrin showed a high affinity for various voltage-gated sodium channels like scn1lab, cacna1sb, and clcn3. Finally, from the results, we found that fenpropathrin caused cardiomegaly, which may have been induced by the voltage-gated sodium channel disruption. This study highlights the significant disruption of fenpropathrin in the cardiovascular system and emphasizes the need for further research on the health implications of this pesticide.<\/jats:p>","DOI":"10.3390\/biology12091214","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:07:37Z","timestamp":1693994857000},"page":"1214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Effect of the Pyrethroid Pesticide Fenpropathrin on the Cardiac Performance of Zebrafish and the Potential Mechanism of Toxicity"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-9827","authenticated-orcid":false,"given":"Ferry","family":"Saputra","sequence":"first","affiliation":[{"name":"Department of Chemistry, Chung Yuan Christian University, Taoyuan 320314, Taiwan"},{"name":"Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Heng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chinese Culture University, Taipei 11114, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6398-1828","authenticated-orcid":false,"given":"Marri Jmelou M.","family":"Roldan","sequence":"additional","affiliation":[{"name":"The Graduate School, University of Santo Tomas, Manila 1008, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-6763","authenticated-orcid":false,"given":"Honeymae C.","family":"Alos","sequence":"additional","affiliation":[{"name":"The Graduate School, University of Santo Tomas, Manila 1008, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlaine A.","family":"Aventurado","sequence":"additional","affiliation":[{"name":"The Graduate School, University of Santo Tomas, Manila 1008, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5906-9710","authenticated-orcid":false,"given":"Ross D.","family":"Vasquez","sequence":"additional","affiliation":[{"name":"The Graduate School, University of Santo Tomas, Manila 1008, Philippines"},{"name":"Department of Pharmacy, Faculty of Pharmacy, University of Santo Tomas, Manila 1008, Philippines"},{"name":"Research Center for Natural and Applied Sciences, University of Santo Tomas, Manila 1008, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6398-8672","authenticated-orcid":false,"given":"Chung-Der","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chung Yuan Christian University, Taoyuan 320314, Taiwan"},{"name":"Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan 320314, Taiwan"},{"name":"Research Center for Aquatic Toxicology and Pharmacology, Chung Yuan Christian University, Taoyuan 320314, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"ref_1","unstructured":"Zimdahl, R.L. (2010). A History of Weed Science in the United States, Elsevier Science."},{"key":"ref_2","unstructured":"Rao, V.S. (2017). Principles of Weed Science, CRC Press."},{"key":"ref_3","unstructured":"Motarjemi, Y. (2014). Encyclopedia of Food Safety, Academic Press."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0921-3449(98)00090-1","article-title":"Persistence and accumulation of some organic insecticides in Nile water and fish","volume":"27","author":"Madbouly","year":"1999","journal-title":"Resour. Conserv. Recycl."},{"key":"ref_5","first-page":"58","article-title":"Alterations in biochemical parameters of the freshwater fish, Alburnus mossulensis, exposed to sub-lethal concentrations of Fenpropathrin","volume":"2","author":"Banaee","year":"2014","journal-title":"Int. J. Aquat. Biol."},{"key":"ref_6","unstructured":"Kanawi, E., Budd, R., and Tjeerdema, R.S. (2013). Reviews of Environmental Contamination and Toxicology, Springer."},{"key":"ref_7","unstructured":"Robert, K. (2010). Hayes\u2019 Handbook of Pesticide Toxicology, Academic Press. [3rd ed.]."},{"key":"ref_8","unstructured":"Ministry of Health and Welfare (2023, March 16). Standards for Pesticide Residue Limits in Foods, Available online: https:\/\/law.moj.gov.tw\/ENG\/LawClass\/LawGetFile.ashx?FileId=0000007831&lan=E."},{"key":"ref_9","first-page":"e07864","article-title":"Targeted review of maximum residue levels (MRLs) for bifenthrin","volume":"21","author":"Authority","year":"2023","journal-title":"EFSA J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0378-4274(02)00183-2","article-title":"Pyrethroid exposure of the general population\u2014Is this due to diet","volume":"134","author":"Schuttens","year":"2002","journal-title":"Toxicol. Lett."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1289\/ehp.02110507","article-title":"Residential pesticide use during pregnancy among a cohort of urban minority women","volume":"110","author":"Whyatt","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s12035-014-9057-2","article-title":"Fenpropathrin, a widely used pesticide, causes dopaminergic degeneration","volume":"53","author":"Xiong","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41420-020-00313-y","article-title":"Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system","volume":"6","author":"Jiao","year":"2020","journal-title":"Cell Death Discov."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"173586","DOI":"10.1016\/j.ejphar.2020.173586","article-title":"Asparagine endopeptidase inhibitor protects against fenpropathrin-induced neurodegeneration via suppressing \u03b1-synuclein aggregation and neuroinflammation","volume":"888","author":"Yu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_15","first-page":"165","article-title":"Effect of 28-day exposure to fenpropathrin on the activities of serum alanine transaminase and liver antioxidant enzymes in mice","volume":"59","year":"2015","journal-title":"J. Vet. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.pharep.2015.12.002","article-title":"The 28-day exposure to fenpropathrin decreases locomotor activity and reduces activity of antioxidant enzymes in mice brains","volume":"68","year":"2016","journal-title":"Pharmacol. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/bdrc.20206","article-title":"Zebrafish embryos and larvae: A new generation of disease models and drug screens","volume":"93","author":"Ali","year":"2011","journal-title":"Birth Defects Res. Part C Embryo Today Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nrd4627","article-title":"Zebrafish as tools for drug discovery","volume":"14","author":"MacRae","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/bs.ctdb.2016.10.007","article-title":"Zebrafish in toxicology and environmental health","volume":"124","author":"Bambino","year":"2017","journal-title":"Curr. Top. Dev. Biol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s10695-022-01134-9","article-title":"Fenpropathrin exposure induces neurotoxicity in zebrafish embryos","volume":"48","author":"Yu","year":"2022","journal-title":"Fish Physiol. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1161\/CIRCRESAHA.122.320396","article-title":"Zebrafish models of cardiac disease: From fortuitous mutants to precision medicine","volume":"130","year":"2022","journal-title":"Circ. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"940484","DOI":"10.3389\/fnmol.2022.940484","article-title":"Zebrafish as a model organism for neurodegenerative disease","volume":"15","author":"Chia","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"713963","DOI":"10.3389\/fphar.2021.713963","article-title":"Advances of zebrafish in neurodegenerative disease: From models to drug discovery","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Santoso, F., Farhan, A., Castillo, A.L., Malhotra, N., Saputra, F., Kurnia, K.A., Chen, K.H.-C., Huang, J.-C., Chen, J.-R., and Hsiao, C.-D. (2020). An Overview of Methods for Cardiac Rhythm Detection in Zebrafish. Biomedicines, 8.","DOI":"10.3390\/biomedicines8090329"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2165\/00139709-200524020-00003","article-title":"Poisoning due to pyrethroids","volume":"24","author":"Bradberry","year":"2005","journal-title":"Toxicol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/bs.ctm.2016.05.001","article-title":"Cardiac Na channels: Structure to function","volume":"Volume 78","author":"DeMarco","year":"2016","journal-title":"Current Topics in Membranes"},{"key":"ref_28","unstructured":"Organisation for Economic Cooperation and Development (2023, August 30). Test No. 203: Fish, Acute Toxicity Test, Available online: https:\/\/www.oecd-ilibrary.org\/environment\/test-no-203-fish-acute-toxicity-test_9789264069961-en."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/978-1-61779-523-7_2","article-title":"Quantifying cardiac functions in embryonic and adult zebrafish","volume":"83","author":"Hoage","year":"2012","journal-title":"Cardiovasc. Dev. Methods Protoc."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sampurna, B.P., Audira, G., Juniardi, S., Lai, Y.-H., and Hsiao, C.-D. (2018). A simple imagej-based method to measure cardiac rhythm in zebrafish embryos. Inventions, 3.","DOI":"10.3390\/inventions3020021"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Santoso, F., Krylov, V.V., Castillo, A.L., Saputra, F., Chen, H.-M., Lai, H.-T., and Hsiao, C.-D. (2020). Cardiovascular performance measurement in water fleas by utilizing high-speed videography and ImageJ software and its application for pesticide toxicity assessment. Animals, 10.","DOI":"10.3390\/ani10091587"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Rueden, C.T., Schindelin, J., Hiner, M.C., DeZonia, B.E., Walter, A.E., Arena, E.T., and Eliceiri, K.W. (2017). ImageJ2: ImageJ for the next generation of scientific image data. BMC Bioinform., 18.","DOI":"10.1186\/s12859-017-1934-z"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: An open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-2269-7_19","article-title":"Small-molecule library screening by docking with PyRx","volume":"1263","author":"Dallakyan","year":"2015","journal-title":"Chem. Biol. Methods Protoc."},{"key":"ref_35","unstructured":"EPA (United States Environmental Protection Agency) (2023, March 27). Technical Overview of Ecological Risk Assessment\u2014Analysis Phase: Ecological Effects Characterization, Available online: https:\/\/www.epa.gov\/pesticide-science-and-assessing-pesticide-risks\/technical-overview-ecological-risk-assessment-0."},{"key":"ref_36","unstructured":"Gupta, R.C. (2019). Biomarkers in Toxicology, Academic Press. [2nd ed.]."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1124\/jpet.110.171850","article-title":"Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons","volume":"336","author":"Cao","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2007.05.012","article-title":"Differential pharmacology of the cardiac anionic background current IAB","volume":"569","author":"Borg","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"A17","DOI":"10.1067\/mhj.2000.110282","article-title":"Cardiomegaly as a possible cause of lung dysfunction in patients with heart failure","volume":"140","author":"Agostoni","year":"2000","journal-title":"Am. Heart J."},{"key":"ref_40","unstructured":"Amin, H., and Siddiqui, W.J. (2021). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cardfail.2006.10.018","article-title":"Pulmonary function changes associated with cardiomegaly in chronic heart failure","volume":"13","author":"Olson","year":"2007","journal-title":"J. Card. Fail."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/PAT.0b013e3283513f54","article-title":"Cardiomegaly is a common arrhythmogenic substrate in adult sudden cardiac deaths, and is associated with obesity","volume":"44","author":"Tavora","year":"2012","journal-title":"Pathology"},{"key":"ref_43","first-page":"526","article-title":"Chronic Toxicity of Ectomethrin: A Biochemical and Histological Study","volume":"42","author":"Othman","year":"2019","journal-title":"Egypt. J. Histol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1007\/s11356-019-05336-2","article-title":"Toxic effect of alpha cypermethrin, an environmental pollutant, on myocardial tissue in male wistar rats","volume":"27","author":"Ghazouani","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_45","unstructured":"Ramanlal, R., and Gupta, V. (2020). StatPearls [Internet], StatPearls Publishing."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"149","DOI":"10.36290\/vnl.2019.029","article-title":"Anaphylactic symptoms and anaphylactic shock","volume":"65","author":"Novosad","year":"2019","journal-title":"Vnitr. Lek."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.chest.2017.12.021","article-title":"Management of refractory vasodilatory shock","volume":"154","author":"Jentzer","year":"2018","journal-title":"Chest"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0163-7258(94)90033-7","article-title":"Calcium antagonists and vasodilation","volume":"64","author":"Godfraind","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1569-2558(08)60366-5","article-title":"Calcium Channels and Vasodilation","volume":"8","author":"Alison","year":"1994","journal-title":"Adv. Mol. Cell Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"105612","DOI":"10.1016\/j.aquatox.2020.105612","article-title":"Osmoregulatory profiles and gill histological changes in Nile tilapia (Oreochromis niloticus) exposed to lambda-cyhalothrin","volume":"227","author":"Fernandes","year":"2020","journal-title":"Aquat. Toxicol."},{"key":"ref_51","first-page":"e32746","article-title":"Management of Lambda-Cyhalothrin Poisoning in a North Indian Healthcare Setup: A Rare Case","volume":"14","author":"Sudan","year":"2022","journal-title":"Cureus"},{"key":"ref_52","first-page":"514","article-title":"Pyrethroid insecticides evoke neurotransmitter release from rabbit striatal slices","volume":"246","author":"Eells","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/pest.1999.2440","article-title":"In vivo effects of deltamethrin on dopamine neurochemistry and the role of augmented neurotransmitter release","volume":"65","author":"Kirby","year":"1999","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1167\/iovs.03-0997","article-title":"Dopaminergic vasodilation in the choroidal circulation by d1\/d5 receptor activation","volume":"45","author":"Reitsamer","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1152\/jn.1995.74.3.1137","article-title":"Voltage-dependent calcium channels in rat midbrain dopamine neurons: Modulation by dopamine and GABAB receptors","volume":"74","author":"Cardozo","year":"1995","journal-title":"J. Neurophysiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.neuroscience.2014.10.037","article-title":"Dopamine midbrain neurons in health and Parkinson\u2019s disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels","volume":"284","author":"Dragicevic","year":"2015","journal-title":"Neuroscience"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0378-4274(92)90216-7","article-title":"Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes","volume":"64","author":"Narahashi","year":"1992","journal-title":"Toxicol. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/ps.1574","article-title":"Pyrethroids, knockdown resistance and sodium channels","volume":"64","author":"Soderlund","year":"2008","journal-title":"Pest Manag. Sci. Former. Pestic. Sci."},{"key":"ref_59","first-page":"1067","article-title":"Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts","volume":"298","author":"Spencer","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.taap.2003.12.013","article-title":"Effects of pyrethroids on voltage-sensitive calcium channels: A critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity","volume":"196","author":"Shafer","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10158-006-0038-7","article-title":"Pyrethroid action on calcium channels: Neurotoxicological implications","volume":"7","author":"Clark","year":"2007","journal-title":"Invertebr. Neurosci."},{"key":"ref_62","first-page":"1","article-title":"Voltage-gated calcium channels in honey bees: Physiological roles and potential targets for insecticides","volume":"2013","author":"Quintavalle","year":"2013","journal-title":"BioSci. Master Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceca.2009.12.014","article-title":"The dysregulation of intracellular calcium in Alzheimer disease","volume":"47","author":"Supnet","year":"2010","journal-title":"Cell Calcium"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCRESAHA.117.310230","article-title":"Calcium and excitation-contraction coupling in the heart","volume":"121","author":"Eisner","year":"2017","journal-title":"Circ. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1113\/expphysiol.2013.077305","article-title":"Calcium in the heart: From physiology to disease","volume":"99","author":"Eisner","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_66","unstructured":"Fernandez, B. (2022). Biology of Cardiovascular and Metabolic Diseases, Academic Press."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1113\/jphysiol.2008.165860","article-title":"Phenomics of cardiac chloride channels: The systematic study of chloride channel function in the heart","volume":"587","author":"Duan","year":"2009","journal-title":"J. Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1159\/000343316","article-title":"The role of swelling-activated chloride currents (ICL, swell) in the regulatory volume decrease response of freshly dissociated rat articular chondrocytes","volume":"30","author":"Ponce","year":"2012","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbamem.2003.10.008","article-title":"Cell volume regulation and swelling-activated chloride channels","volume":"1618","author":"Sardini","year":"2003","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0300-483X(01)00569-8","article-title":"Mechanisms of pyrethroid neurotoxicity: Implications for cumulative risk assessment","volume":"171","author":"David","year":"2002","journal-title":"Toxicology"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1999.8848","article-title":"The role of voltage-gated chloride channels in type II pyrethroid insecticide poisoning","volume":"163","author":"Forshaw","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_72","first-page":"755","article-title":"Actions of pyrethroid insecticides on voltage-gated chloride channels in neuroblastoma cells","volume":"18","author":"Ray","year":"1997","journal-title":"Neurotoxicology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/iub.2192","article-title":"Regulation of GATA1 levels in erythropoiesis","volume":"72","author":"Caballero","year":"2020","journal-title":"IUBMB Life"},{"key":"ref_74","first-page":"4375","article-title":"Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis","volume":"111","author":"Tsukamoto","year":"2008","journal-title":"Blood J. Am. Soc. Hematol."},{"key":"ref_75","first-page":"245","article-title":"Oral toxicity of deltamethrin and fenvalerate in Swiss mice","volume":"8","author":"Latuszynska","year":"2001","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.etp.2008.07.001","article-title":"Effects of cypermethrin on some clinico-hemato-biochemical and pathological parameters in male dwarf goats (Capra hircus)","volume":"61","author":"Khan","year":"2009","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4103\/0971-6580.155364","article-title":"Hematobiochemical evaluation of dermal subacute cypermethrin toxicity in buffalo calves","volume":"21","author":"Dar","year":"2014","journal-title":"Toxicol. Int."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Guo, S., Wu, Y., Li, W., and Xiao, P. (2023). Tralomethrin causes cardiovascular toxicity in zebrafish (Danio rerio) embryos. Environ. Toxicol.","DOI":"10.1002\/tox.23911"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/toxsci\/kfj020","article-title":"Relative potencies for acute effects of pyrethroids on motor function in rats","volume":"89","author":"Wolansky","year":"2006","journal-title":"Toxicol. Sci."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/12\/9\/1214\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:46:06Z","timestamp":1760129166000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/12\/9\/1214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":79,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["biology12091214"],"URL":"https:\/\/doi.org\/10.3390\/biology12091214","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,6]]}}}