{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:34:29Z","timestamp":1760150069515,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French government"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>To adapt to a new environment, individuals must alternate between exploiting previously learned \u201caction\u2013consequence\u201d combinations and exploring new actions for which the consequences are unknown: they face an exploration\/exploitation trade-off. The neural substrates of these behaviors and the factors that may relate to the interindividual variability in their expression remain overlooked, in particular when considering neural connectivity patterns. Here, to trigger environmental uncertainty, false feedbacks were introduced in the second phase of an associative learning task. Indices reflecting exploitation and cost of uncertainty were computed. Changes in the intrinsic connectivity were determined using resting-state functional connectivity (rFC) analyses before and after performing the \u201ccheated\u201d phase of the task in the MRI. We explored their links with behavioral and psychological factors. Dispersion in the participants\u2019 cost of uncertainty was used to categorize two groups. These groups showed different patterns of rFC changes. Moreover, in the overall sample, exploitation was correlated with rFC changes between (1) the anterior cingulate cortex and the cerebellum region 3, and (2) the left frontal inferior gyrus (orbital part) and the right frontal inferior gyrus (triangular part). Anxiety and doubt about action propensity were weakly correlated with some rFC changes. These results demonstrate that the exploration\/exploitation trade-off involves the modulation of cortico-cerebellar intrinsic connectivity.<\/jats:p>","DOI":"10.3390\/biology12101323","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T10:23:42Z","timestamp":1696933422000},"page":"1323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interindividual Brain and Behavior Differences in Adaptation to Unexpected Uncertainty"],"prefix":"10.3390","volume":"12","author":[{"given":"C\u00e9lia","family":"Soussi","sequence":"first","affiliation":[{"name":"INCIA CNRS 5287, University of Bordeaux, 33076 Bordeaux, France"},{"name":"UNICAEN, INSERM, U1237, PhIND \u201cPhysiopathology and Imaging of Neurological Disorders\u201d, NeuroPresage Team, Cyceron, Normandy University, 14000 Caen, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-2362","authenticated-orcid":false,"given":"Sylvie","family":"Berthoz","sequence":"additional","affiliation":[{"name":"INCIA CNRS 5287, University of Bordeaux, 33076 Bordeaux, France"},{"name":"Department of Psychiatry for Adolescents and Young Adults, Institut Mutualiste Montsouris, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7671-9941","authenticated-orcid":false,"given":"Valentine","family":"Chirokoff","sequence":"additional","affiliation":[{"name":"INCIA CNRS 5287, University of Bordeaux, 33076 Bordeaux, France"},{"name":"Ecole Pratique des Hautes Etudes, Section of Life and Earth Sciences, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4299-3050","authenticated-orcid":false,"given":"Sandra","family":"Chanraud","sequence":"additional","affiliation":[{"name":"INCIA CNRS 5287, University of Bordeaux, 33076 Bordeaux, France"},{"name":"Ecole Pratique des Hautes Etudes, Section of Life and Earth Sciences, PSL Research University, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1098\/rstb.2007.2098","article-title":"Should I Stay or Should I Go? 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