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Recent studies suggest a significant role of zinc (Zn) and copper (Cu) deficiency in atheromatous plaque formation. Furthermore, hair was previously described as a valuable source of information on elemental burden during the 6\u20138 week period before sampling. The aim of this study was to investigate the possibility of correlation between the extent of CAD evaluated with the SYNergy Between PCI With TAXUS and the Cardiac Surgery (SYNTAX) score with Cu and Zn content in hair samples, as well as with the Cu\/Zn ratio in a cohort of 130 patients. Our findings describe a statistically significant inverse correlation between Cu content and the Cu\/Zn ratio in hair samples and the extent of CAD. In contrast, no significant correlation was found between Zn content and the extent of CAD. Considering the scarcity of existing data on the subject, the analysis of hair samples could yield a novel insight into elemental deficiencies and their potential influence on CAD extent.<\/jats:p>","DOI":"10.3390\/biology12111407","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:23:39Z","timestamp":1699356219000},"page":"1407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Relationship between Copper, Zinc, and Copper-to-Zinc Ratio in Hair and Severity of Coronary Artery Disease according to the SYNTAX Score"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-3240","authenticated-orcid":false,"given":"Ewelina A.","family":"Dziedzic","sequence":"first","affiliation":[{"name":"Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-2200","authenticated-orcid":false,"given":"Jakub S.","family":"G\u0105sior","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-7023","authenticated-orcid":false,"given":"Agnieszka","family":"Tuzimek","sequence":"additional","affiliation":[{"name":"Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Czestkowska","sequence":"additional","affiliation":[{"name":"Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Beck","sequence":"additional","affiliation":[{"name":"Nencki Institute of Experimental Biology, Polish Academy of Sciences, 00-901 Warsaw, Poland"},{"name":"Medical Faculty, Lazarski University, 02-662 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Jaczewska","sequence":"additional","affiliation":[{"name":"Medical Faculty, Lazarski University, 02-662 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Zgnilec","sequence":"additional","affiliation":[{"name":"Military Institute of Aviation Medicine, 01-755 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1430-397X","authenticated-orcid":false,"given":"Andrzej","family":"Osiecki","sequence":"additional","affiliation":[{"name":"Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4585-1744","authenticated-orcid":false,"given":"Miros\u0142aw","family":"Kwa\u015bny","sequence":"additional","affiliation":[{"name":"Institute of Optoelectronics, Military University of Technology, 00-908 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-8578","authenticated-orcid":false,"given":"Marek J.","family":"D\u0105browski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Bielanski Hospital, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wac\u0142aw","family":"Kochman","sequence":"additional","affiliation":[{"name":"Cardiovascular Clinic, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref_1","unstructured":"World Health Organisation (2023, May 20). 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