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The larynx in particular plays a crucial role, as it enables the vocal folds to meet and converts the exhaled air from our lungs into audible sounds. Voice production requires precise and sustained exhalation, which generates an air pressure\/flow that creates the pressure in the glottis required for voice production. Voluntary vocal production begins in the laryngeal motor cortex (LMC), a structure found in all mammals, although the specific location in the cortex varies in humans. The LMC interfaces with various structures of the central autonomic network associated with cardiorespiratory regulation to allow the perfect coordination between breathing and vocalization. The main subcortical structure involved in this relationship is the mesencephalic periaqueductal grey matter (PAG). The PAG is the perfect link to the autonomic pontomedullary structures such as the parabrachial complex (PBc), the K\u00f6lliker\u2013Fuse nucleus (KF), the nucleus tractus solitarius (NTS), and the nucleus retroambiguus (nRA), which modulate cardiovascular autonomic function activity in the vasomotor centers and respiratory activity at the level of the generators of the laryngeal-respiratory motor patterns that are essential for vocalization. These cores of autonomic structures are not only involved in the generation and modulation of cardiorespiratory responses to various stressors but also help to shape the cardiorespiratory motor patterns that are important for vocal production. Clinical studies show increased activity in the central circuits responsible for vocalization in certain speech disorders, such as spasmodic dysphonia because of laryngeal dystonia.<\/jats:p>","DOI":"10.3390\/biology13020118","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T04:09:21Z","timestamp":1707797361000},"page":"118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Central Autonomic Mechanisms Involved in the Control of Laryngeal Activity and Vocalization"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-7757","authenticated-orcid":false,"given":"Marta","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Carrillo-Franco","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7137-5161","authenticated-orcid":false,"given":"Carmen","family":"Morales-Luque","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Stefan","family":"Dawid-Milner","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9023-3710","authenticated-orcid":false,"given":"Manuel V\u00edctor","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 M\u00e1laga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.resp.2015.06.010","article-title":"Testing the evolutionary conservation of vocal motoneurons in vertebrates","volume":"224","author":"Blubaum","year":"2016","journal-title":"Respir. 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