{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:58:13Z","timestamp":1792789093391,"version":"4.5.0"},"reference-count":146,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"publisher","award":["22ZR1479900"],"award-info":[{"award-number":["22ZR1479900"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"publisher","award":["82270314"],"award-info":[{"award-number":["82270314"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Shanghai Natural Science Foundation","doi-asserted-by":"publisher","award":["2022020405"],"award-info":[{"award-number":["2022020405"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["22ZR1479900"],"award-info":[{"award-number":["22ZR1479900"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["82270314"],"award-info":[{"award-number":["82270314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["2022020405"],"award-info":[{"award-number":["2022020405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Innovation Project of the Distinguished Medical Team in Ningbo","award":["22ZR1479900"],"award-info":[{"award-number":["22ZR1479900"]}]},{"name":"Innovation Project of the Distinguished Medical Team in Ningbo","award":["82270314"],"award-info":[{"award-number":["82270314"]}]},{"name":"Innovation Project of the Distinguished Medical Team in Ningbo","award":["2022020405"],"award-info":[{"award-number":["2022020405"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Hemodynamics is the eternal theme of the circulatory system. Abnormal hemodynamics and cardiac and pulmonary development intertwine to form the most important features of children with congenital heart diseases (CHDs), thus determining these children\u2019s long-term quality of life. Here, we review the varieties of hemodynamic abnormalities that exist in children with CHDs, the recently developed neonatal rodent models of CHDs, and the inspirations these models have brought us in the areas of cardiomyocyte proliferation and maturation, as well as in alveolar development. Furthermore, current limitations, future directions, and clinical decision making based on these inspirations are highlighted. Understanding how CHD-associated hemodynamic scenarios shape postnatal heart and lung development may provide a novel path to improving the long-term quality of life of children with CHDs, transplantation of stem cell-derived cardiomyocytes, and cardiac regeneration.<\/jats:p>","DOI":"10.3390\/biology13040234","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:32:56Z","timestamp":1711891976000},"page":"234","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hemodynamic Melody of Postnatal Cardiac and Pulmonary Development in Children with Congenital Heart Diseases"],"prefix":"10.3390","volume":"13","author":[{"given":"Sixie","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Children\u2019s Medical Center, Shanghai 200127, China"},{"name":"Shanghai Institute for Pediatric Congenital Heart Disease, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Children\u2019s Medical Center, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8808-2810","authenticated-orcid":false,"given":"Lincai","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Children\u2019s Medical Center, Shanghai 200127, China"},{"name":"Shanghai Institute for Pediatric Congenital Heart Disease, Shanghai Children\u2019s Medical Center, School of Medicine, Shanghai Jiao Tong University, National Children\u2019s Medical Center, Shanghai 200127, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1538-7836.2011.04312.x","article-title":"Discovery of the cardiovascular system: From Galen to William Harvey","volume":"9","author":"Aird","year":"2011","journal-title":"J. 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