{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:48:53Z","timestamp":1765889333523,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology, Taiwan","award":["MOST107-2311-B992-001","KAFGH-ZY-A-109019"],"award-info":[{"award-number":["MOST107-2311-B992-001","KAFGH-ZY-A-109019"]}]},{"name":"Zouying Armed Forced General Hospital","award":["MOST107-2311-B992-001","KAFGH-ZY-A-109019"],"award-info":[{"award-number":["MOST107-2311-B992-001","KAFGH-ZY-A-109019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Padina minor is a seaweed rich in polysaccharides often used in food, feed, fertilizers, and antibacterial drugs. This study is the first to evaluate the effect of feeding zebrafish with Padina minor extract on preventing and treating C. albicans infections. This study evaluated the growth, survival, and disease resistance effects of P. minor extract on zebrafish. The fish were divided into four groups: three groups treated with 1%, 5%, or 10% P. minor extract and one untreated group (c, control). Subsequently, we analyzed how the extract affected the immune function of zebrafish infected with C. albicans. Based on the lethal concentration (LC50) calculated in the first stage, 1% was used as the effective therapeutic concentration. The results showed that the growth rate of the 1% feed group was the best, and no significant difference in survival rates between the four groups was observed. Feeding with 1% P. minor extract downregulated the expression of key inflammatory genes like tumor necrosis factor-alpha (TNF-\u03b1), interleukin-1\u03b2 (IL-1\u03b2), and IL-10, effectively preventing and treating C. albicans infections in zebrafish. This study is a preliminary evaluation of the therapeutic efficacy of P. minor extracts against C. albicans.<\/jats:p>","DOI":"10.3390\/biology13060384","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T09:33:31Z","timestamp":1716802411000},"page":"384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Padina Minor Extract Confers Resistance against Candida Albicans Infection: Evaluation in a Zebrafish Model"],"prefix":"10.3390","volume":"13","author":[{"given":"Chang-Cheng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"},{"name":"Department of Obstetrics and Gynecology, Zuoying Armed Forces General Hospital, Kaohsiung 81342, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-1930","authenticated-orcid":false,"given":"De-Sing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 811213, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Hao","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Zuoying Armed Forces General Hospital, Kaohsiung 81342, Taiwan"},{"name":"Department of Nursing, Shu-Zen Junior of Medicine and Management, Kaohsiung 82144, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh-Yu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Aquaculture, National Kaohsiung University of Science and Technology, Kaohsiung 811213, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4411-044X","authenticated-orcid":false,"given":"Zhi-Hong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-016-0236-5","article-title":"Zebrafish and Medaka: New model organisms for modern biomedical research","volume":"23","author":"Lin","year":"2016","journal-title":"J. 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