{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:58:05Z","timestamp":1785365885710,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Food and Agriculture","award":["2815NA113"],"award-info":[{"award-number":["2815NA113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Some rodent species cause significant damage to agriculture and forestry, and some can transmit pathogens to humans and livestock. The common vole (Microtus arvalis) is widespread in Europe, and its population outbreaks have resulted in massive crop loss. Bait-based fertility control could contribute to rodent pest management. Bait containing 4-vinylcyclohexene diepoxide (VCD) and triptolide (TP), registered as ContraPest\u00ae, was delivered to male common voles for 14 or 28 consecutive days. The effects on reproductive structures and residues in the liver and testes were assessed. There was no effect on testis weight, sperm viability, sperm motility and oxidative stress in sperm cells. Results regarding the mitochondrial membrane potential of sperm, DNA fragmentation and progressively motile sperm cells were inconclusive. However, there was an increase in morphological sperm defects in voles treated for 14\/28 days and fewer normal sperm cells in voles treated for 28 days. There were no TP residues in the testes, few and low TP residues and no VCD residues in liver tissues, making considerable secondary exposure to non-target species unlikely. Treatments with VCD + TP seemed to have minor effects on the reproductive organs of males. Further studies should evaluate the effect of VCD + TP on females and on the reproductive success of common voles and other pest rodent species.<\/jats:p>","DOI":"10.3390\/biology13060450","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T08:06:06Z","timestamp":1718784366000},"page":"450","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of an Anti-Fertility Product on Reproductive Structures of Common Vole Males and Residues of Compounds"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8198-9490","authenticated-orcid":false,"given":"Kyra","family":"Jacoblinnert","sequence":"first","affiliation":[{"name":"Julius Kuehn-Institute, Federal Research Institute for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics\u2014Rodent Research, 48161 Muenster, Germany"},{"name":"Department of Behavioral Biology, University of Osnabrueck, 49076 Osnabrueck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Reilly","sequence":"additional","affiliation":[{"name":"Julius Kuehn-Institute, Federal Research Institute for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics\u2014Rodent Research, 48161 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9666-8301","authenticated-orcid":false,"given":"Raul","family":"Da Costa","sequence":"additional","affiliation":[{"name":"Centre for Reproductive Medicine and Andrology, University of Muenster, 48149 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Schenke","sequence":"additional","affiliation":[{"name":"Julius Kuehn-Institute, Federal Research Centre for Cultivated Plants, Institute for Ecological Chemistry, Plant Analysis and Stored Product Protection, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-6606","authenticated-orcid":false,"given":"Jens","family":"Jacob","sequence":"additional","affiliation":[{"name":"Julius Kuehn-Institute, Federal Research Institute for Cultivated Plants, Institute for Epidemiology and Pathogen Diagnostics\u2014Rodent Research, 48161 Muenster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1126\/science.130.3380.902","article-title":"Sterile-male method of population control: Successful with some insects, the method may also be effective when applied to other noxious animals","volume":"130","author":"Knipling","year":"1959","journal-title":"Science"},{"key":"ref_2","first-page":"160","article-title":"Principles for population control by gametocides","volume":"26","author":"Davis","year":"1961","journal-title":"Trans. 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