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Ireland","award":["898-792"],"award-info":[{"award-number":["898-792"]}],"id":[{"id":"https:\/\/ror.org\/0271asj38","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Science Foundation Ireland","award":["17\/CDA\/4737"],"award-info":[{"award-number":["17\/CDA\/4737"]}],"id":[{"id":"https:\/\/ror.org\/0271asj38","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Background: While frontotemporal involvement is increasingly recognized in Amyotrophic lateral sclerosis (ALS), the degeneration of limbic networks remains poorly characterized, despite growing evidence of amnestic deficits, impaired emotional processing and deficits in social cognition. Methods: A prospective neuroimaging study was conducted with 204 individuals with ALS and 111 healthy controls. Patients were stratified for hexanucleotide expansion status in C9orf72. A deep-learning-based segmentation approach was implemented to segment the nucleus accumbens, hypothalamus, fornix, mammillary body, basal forebrain and septal nuclei. The cortical, subcortical and white matter components of the Papez circuit were also systematically evaluated. Results: Hexanucleotide repeat expansion carriers exhibited bilateral amygdala, hypothalamus and nucleus accumbens atrophy, and C9orf72 negative patients showed bilateral basal forebrain volume reductions compared to controls. Both patient groups showed left rostral anterior cingulate atrophy, left entorhinal cortex thinning and cingulum and fornix alterations, irrespective of the genotype. Fornix, cingulum, posterior cingulate, nucleus accumbens, amygdala and hypothalamus degeneration was more marked in C9orf72-positive ALS patients. Conclusions: Our results highlighted that mesial temporal and parasagittal subcortical degeneration is not unique to C9orf72 carriers. Our radiological findings were consistent with neuropsychological observations and highlighted the importance of comprehensive neuropsychological testing in ALS, irrespective of the underlying genotype.<\/jats:p>","DOI":"10.3390\/biology13070504","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T09:01:19Z","timestamp":1720429279000},"page":"504","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Limbic Network and Papez Circuit Involvement in ALS: Imaging and Clinical Profiles in GGGGCC Hexanucleotide Carriers in C9orf72 and C9orf72-Negative Patients"],"prefix":"10.3390","volume":"13","author":[{"given":"Foteini","family":"Christidi","sequence":"first","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Kleinerova","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee Ling","family":"Tan","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Delaney","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"},{"name":"Department of Neurology, St James\u2019s Hospital, D08 KC95 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asya","family":"Tacheva","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"},{"name":"Department of Neurology, St James\u2019s Hospital, D08 KC95 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer C.","family":"Hengeveld","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Doherty","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell L.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Smurfit Institute of Genetics, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"Hardiman","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"We Fong","family":"Siah","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Ming","family":"Chang","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmin","family":"Lope","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bede","sequence":"additional","affiliation":[{"name":"Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, D08 W9RT Dublin, Ireland"},{"name":"Department of Neurology, St James\u2019s Hospital, D08 KC95 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(08)70293-X","article-title":"Biomarkers in amyotrophic lateral sclerosis","volume":"8","author":"Turner","year":"2009","journal-title":"Lancet Neurol."},{"key":"ref_2","first-page":"168","article-title":"Longitudinal assessment of grey matter contraction in amyotrophic lateral sclerosis: A tensor based morphometry study","volume":"10","author":"Agosta","year":"2009","journal-title":"Amyotroph. 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