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Protein acetylation, which is a frequently occurring posttranslational modification, plays pivotal roles in the regulation of hypothalamic processes. However, the effects of CIH-induced global protein acetylation on hypothalamic function and endocrine metabolism remain poorly understood. To bridge this knowledge gap, we conducted a study utilizing liquid chromatography\u2013mass spectrometry to analyse the lysine acetylome and proteome of the hypothalamus in healthy infantile mice exposed to 3 weeks of intermittent hypoxia (as a CIH model) compared to normoxic mice (as controls). Our analysis identified and quantified 2699 Kac sites in 2453 proteins. These acetylated proteins exhibited disruptions primarily in endocrine metabolism, the citrate cycle (TCA cycle), synapse function, and circadian entrainment. Additionally, we observed significant down-regulation of proteins that are known to be involved in endocrine hormone secretion. This study aimed to elucidate the molecular mechanisms underlying CIH-induced alterations in protein acetylation within the hypothalamus. By providing valuable insights into the pathophysiological processes associated with CIH and their impacts on hypothalamic function, our findings contribute to a deeper understanding of the consequences stemming from CIH-induced changes in protein acetylation within the hypothalamus as well as its potential role in endocrine impairment.<\/jats:p>","DOI":"10.3390\/biology13080559","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T15:47:32Z","timestamp":1721836052000},"page":"559","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acetylome Analyses Provide New Insights into the Effect of Chronic Intermittent Hypoxia on Hypothalamus-Dependent Endocrine Metabolism Impairment"],"prefix":"10.3390","volume":"13","author":[{"given":"Yaru","family":"Kong","sequence":"first","affiliation":[{"name":"Children\u2019s Hospital Capital Institute of Paediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Graduate School of Peking Union Medical College, Beijing 100730, China"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Children\u2019s Hospital Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Children\u2019s Hospital Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Capital Institute of Paediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Graduate School of Peking Union Medical College, Beijing 100730, China"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Children\u2019s Hospital Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-2491","authenticated-orcid":false,"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Capital Institute of Paediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Graduate School of Peking Union Medical College, Beijing 100730, China"},{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, Children\u2019s Hospital Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Tai","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital Capital Institute of Paediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Children\u2019s Hospital Capital Institute of Paediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1164\/rccm.202310-1857ST","article-title":"Management of Persistent, Post-Adenotonsillectomy Obstructive Sleep Apnea in Children: An Official American Thoracic Society Clinical Practice Guideline","volume":"209","author":"Ehsan","year":"2024","journal-title":"Am. 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