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Methods: HEVe was obtained by maceration and phytochemically analyzed. Its systemic anti-inflammatory activity was assessed by its effect on lipopolysaccharide (LPS)-induced peritonitis in mice. HEVe gel (HEgVe) was employed to evaluate topical anti-inflammatory activity by measuring the ear edema resulting from croton-oil-induced dermatitis in mice. A cell viability assay was conducted to determine the non-cytotoxic concentrations of the HEVe. RAW 264.7 cells were stimulated by LPS to determinate cytokine and nitric oxide production. Results: A phytochemical analysis of the HEVe revealed the presence of phenolic acids, neolignans, flavonoids, and monomeric catechins. The oral treatment of acute peritonitis with HEVe reduced the total leukocytes, neutrophils, TNF-\u03b1, and IL-1\u03b2 and elevated IL-10 levels. The application of the HEgVe reduced local edema. The HEVe on the RAW 264.7 cells exhibited no cytotoxicity, and the cells with HEVe displayed reduced TNF-\u03b1, IL-1\u03b2, and NO levels and increased IL-13 levels. Conclusions: HEVe demonstrated systemic and topical multitarget anti-inflammatory activity, likely due to the combined effects of secondary metabolites. HEVe emerges as a promising herbal remedy for inflammation with minimal cytotoxicity, emphasizing its potential therapeutic significance.<\/jats:p>","DOI":"10.3390\/biology13100776","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:19:37Z","timestamp":1727680777000},"page":"776","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemistry and Evaluation of the Anti-Inflammatory Activity of the Hydroethanolic Extract of Virola\u00a0elongata (Benth.) Warb. Stem Bark"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3155-7429","authenticated-orcid":false,"given":"Bruna Fioravante","family":"Di Serio","sequence":"first","affiliation":[{"name":"Post-Graduate Program in Health Sciences, School of Medicine, Federal University of Mato Grosso (UFMT), Cuiab\u00e1 78060-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-9330","authenticated-orcid":false,"given":"Jessica de Araujo Isaias","family":"Muller","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Health Sciences, School of Medicine, Federal University of Mato Grosso (UFMT), Cuiab\u00e1 78060-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8988-5532","authenticated-orcid":false,"given":"Marcelo Jos\u00e9 Dias","family":"Silva","sequence":"additional","affiliation":[{"name":"Medicinal Plants and Phytotherapeutics Laboratory, Federal University of Alfenas (UNIFAL), Alfenas 37130-001, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana de Freitas","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Health Sciences, School of Medicine, Federal University of Mato Grosso (UFMT), Cuiab\u00e1 78060-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingos Tabajara de Oliveira","family":"Martins","sequence":"additional","affiliation":[{"name":"Pharmacology Division, Department of Basic Health Sciences, School of Medicine, Federal University of Mato Grosso (UFMT), Cuiab\u00e1 78060-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41584-022-00905-1","article-title":"Inflammation and DNA damage: Cause, effect or both","volume":"19","author":"Pezone","year":"2023","journal-title":"Nat. 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