{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:25:19Z","timestamp":1775017519890,"version":"3.50.1"},"reference-count":91,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFF1000500"],"award-info":[{"award-number":["2022YFF1000500"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFD1200802"],"award-info":[{"award-number":["2021YFD1200802"]}]},{"name":"National Key Research and Development Program of China","award":["32172691"],"award-info":[{"award-number":["32172691"]}]},{"name":"National Natural Science Foundation of China","award":["2022YFF1000500"],"award-info":[{"award-number":["2022YFF1000500"]}]},{"name":"National Natural Science Foundation of China","award":["2021YFD1200802"],"award-info":[{"award-number":["2021YFD1200802"]}]},{"name":"National Natural Science Foundation of China","award":["32172691"],"award-info":[{"award-number":["32172691"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Intensively farmed animals such as pigs inevitably experience a certain degree of psychological stress, which leads to a reduction in production performance. Mental health traits are currently difficult to measure, resulting in a gap in understanding their genetic basis. To address this challenge, we propose a computational framework called mental health of animals (MeHA), capable of revealing genes related to animal mental health traits. Using MeHA, we identified 109 candidate genes associated with pig mental health and discovered their intricate connections with critical functions, such as memory, cognition, and neural development, which are essential components of mental health and cognitive performance. Importantly, our findings provide evidence of the potential impact of these genes on economically important traits, including meat quality and piglet survival. This research underscores the importance of genetic studies in enhancing our understanding of animal behavior and cognition, as well as promoting agricultural practices. By applying our approach to study the genetic basis of mental health in pigs as a case, we confirmed that our framework is an effective way to reveal genetic factors affecting animal mental health traits, which contributes to animal welfare and has potential implications for understanding human mental disorders.<\/jats:p>","DOI":"10.3390\/biology13100843","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T10:49:22Z","timestamp":1729507762000},"page":"843","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["MeHA: A Computational Framework in Revealing the Genetic Basis of Animal Mental Health Traits Under an Intensive Farming System\u2014A Case Study in Pigs"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6806-6249","authenticated-orcid":false,"given":"Jinyun","family":"Jiang","sequence":"first","affiliation":[{"name":"College of Animal 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University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-7129","authenticated-orcid":false,"given":"Kan","family":"He","sequence":"additional","affiliation":[{"name":"Center for Stem Cell and Translational Medicine, School of Life Sciences, Anhui University, Hefei 230601, China"},{"name":"Traditional Chinese Medicine Research Centre, School of Life Sciences, Anhui University, Hefei 230601, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Sciences, Zhejiang University, Hangzhou 310058, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"ref_1","first-page":"121","article-title":"Feeding and management strategies for sire pigs in intensive pig farms","volume":"6","author":"Zhang","year":"2023","journal-title":"Anim. 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