{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:19:01Z","timestamp":1782145141515,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005286","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Mato Grosso (FAPEMAT)","doi-asserted-by":"publisher","award":["571424\/2014"],"award-info":[{"award-number":["571424\/2014"]}],"id":[{"id":"10.13039\/501100005286","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)\u2014fellowship","award":["571424\/2014"],"award-info":[{"award-number":["571424\/2014"]}]},{"name":"Pro-reitoria de Pesquisa (Propeq) UFMT","award":["571424\/2014"],"award-info":[{"award-number":["571424\/2014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Copaifera sp. is a native tree in the Amazon region. Copaiba oleoresin has components such as sesquiterpenes, which have anti-inflammatory and antioxidant potential. Liver cirrhosis is the end stage of liver disease with limited therapeutic options. We aimed to evaluate the effect of copaiba oleoresin supplementation on the liver of animals with thioacetamide (TAA)-induced cirrhosis. For the induction of liver cirrhosis, 100 mg\/kg of TAA was administered intraperitoneally twice a week for 8 weeks. A total of 200 mg\/kg\/day of copaiba oleoresin was administered via gavage for the same period. Copaiba oleoresin supplementation improved cirrhosis-associated cachexia by increasing weight gain and body fat. In addition, copaiba oleoresin attenuated systemic inflammation, as shown by the decrease in the circulating C-reactive protein. In the liver, the copaiba oleoresin decreased carbonyl proteins and increased IL-10 compared with TAA-treated rats. TAA groups demonstrated increased SOD, catalase, GST, and GSH activity in the liver. In conclusion, the supplementation of copaiba oleoresin demonstrated a beneficial systemic effect in alleviating cirrhotic cachexia and antioxidant and anti-inflammatory action in the liver. However, it failed to improve the serological and histological markers of liver damage, which could be associated with the advanced stage of the disease.<\/jats:p>","DOI":"10.3390\/biology13110853","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T04:28:43Z","timestamp":1729657723000},"page":"853","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Copaiba Oleoresin Improves Weight Gain and IL-10 Concentration, with No Impact on Hepatic Histology, in Liver Cirrhosis"],"prefix":"10.3390","volume":"13","author":[{"given":"Maiara","family":"Taffarel","sequence":"first","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Sulzbacher da","family":"Silva","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lica Macedo Borg\u00eas","family":"Paulino","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Ortega","family":"Telles","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Trigueiro","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6553-3858","authenticated-orcid":false,"given":"Cintia Vieira dos","family":"Santos","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morenna Alana","family":"Giordani","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Ferreira","family":"Nascimento","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"},{"name":"ICS\u2014Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo Henrique","family":"Aguiar","sequence":"additional","affiliation":[{"name":"ICNHS\u2014Institute of Natural, Human and Social Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5070-0043","authenticated-orcid":false,"given":"Val\u00e9ria Dornelles Gindri","family":"Sinhorin","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biotechnology and Biodiversity of the Pro Centro-Oeste Network, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-8399","authenticated-orcid":false,"given":"Carla Regina","family":"Andrighetti","sequence":"additional","affiliation":[{"name":"ICS\u2014Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata de Azevedo Melo","family":"Luvizotto","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"},{"name":"ICS\u2014Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-0028","authenticated-orcid":false,"given":"Gisele Facholi","family":"Bomfim","sequence":"additional","affiliation":[{"name":"NUPADS\u2014Center for Research and Teaching Support in Health, Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"},{"name":"ICS\u2014Institute of Health Sciences, Federal University of Mato Grosso, Sinop 78550-728, MT, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jep.2007.03.005","article-title":"Chemical composition and anti-inflammatory activity of copaiba oils from Copaifera cearensis Huber ex Ducke, Copaifera reticulata Ducke and Copaifera multijuga Hayne\u2014A comparative 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