{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:21:50Z","timestamp":1788996110862,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32303046"],"award-info":[{"award-number":["32303046"]}]},{"name":"National Natural Science Foundation of China","award":["PBEA2021ZD01"],"award-info":[{"award-number":["PBEA2021ZD01"]}]},{"name":"National Natural Science Foundation of China","award":["HD-KYH-2022002"],"award-info":[{"award-number":["HD-KYH-2022002"]}]},{"name":"National Natural Science Foundation of China","award":["XTCX2022HYB03"],"award-info":[{"award-number":["XTCX2022HYB03"]}]},{"name":"Research Fund Program of Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture of China","award":["32303046"],"award-info":[{"award-number":["32303046"]}]},{"name":"Research Fund Program of Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture of China","award":["PBEA2021ZD01"],"award-info":[{"award-number":["PBEA2021ZD01"]}]},{"name":"Research Fund Program of Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture of China","award":["HD-KYH-2022002"],"award-info":[{"award-number":["HD-KYH-2022002"]}]},{"name":"Research Fund Program of Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture of China","award":["XTCX2022HYB03"],"award-info":[{"award-number":["XTCX2022HYB03"]}]},{"name":"Hainan Baolu Aquatic Products Technology Co., Ltd. Seed Industry Breeding and Promotion Technology Services","award":["32303046"],"award-info":[{"award-number":["32303046"]}]},{"name":"Hainan Baolu Aquatic Products Technology Co., Ltd. Seed Industry Breeding and Promotion Technology Services","award":["PBEA2021ZD01"],"award-info":[{"award-number":["PBEA2021ZD01"]}]},{"name":"Hainan Baolu Aquatic Products Technology Co., Ltd. Seed Industry Breeding and Promotion Technology Services","award":["HD-KYH-2022002"],"award-info":[{"award-number":["HD-KYH-2022002"]}]},{"name":"Hainan Baolu Aquatic Products Technology Co., Ltd. Seed Industry Breeding and Promotion Technology Services","award":["XTCX2022HYB03"],"award-info":[{"award-number":["XTCX2022HYB03"]}]},{"name":"Hainan University Collaborative Innovation Center Fund","award":["32303046"],"award-info":[{"award-number":["32303046"]}]},{"name":"Hainan University Collaborative Innovation Center Fund","award":["PBEA2021ZD01"],"award-info":[{"award-number":["PBEA2021ZD01"]}]},{"name":"Hainan University Collaborative Innovation Center Fund","award":["HD-KYH-2022002"],"award-info":[{"award-number":["HD-KYH-2022002"]}]},{"name":"Hainan University Collaborative Innovation Center Fund","award":["XTCX2022HYB03"],"award-info":[{"award-number":["XTCX2022HYB03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Flavobacterium davisii is one of the causative agents of columnaris disease, significantly impacting Nile tilapia aquaculture. This study examines the invasion and immune evasion mechanisms of a highly virulent F. davisii strain through transcriptomic profiling of tilapia gills following acute immersion. We identified 8192 differentially expressed genes (DEGs) at 2 h, 6 h, and 12 h post-infection. They are enriched in pathways related to oxidative stress, immune suppression, tissue necrosis, and bacterial infection. Notably, early overexpression of rhamnose-binding lectin and mucin genes facilitated bacterial adhesion. Key immune genes, including those encoding major histocompatibility complex (MHC), immunoglobulins (Ig), Toll-like receptors (TLRs), and chemokines, were downregulated, indicating immune suppression. Conversely, immune evasion genes such as Fc receptor-like (FcRL) and programmed death-ligand 1 (PDL1) were upregulated, along with genes associated with reactive oxygen species (ROS) production, leading to increased tissue damage. Additionally, the upregulation of fibroblast growth factor and collagen genes suggested active tissue repair. In conclusion, F. davisii rapidly invades its host by enhancing adhesion to gill tissues, suppressing immune function, and inducing tissue damage. These findings enhance our understanding of F. davisii infection mechanisms and support the future breeding of disease-resistant tilapia and the development of sustainable control strategies.<\/jats:p>","DOI":"10.3390\/biology13110894","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T10:57:20Z","timestamp":1730717840000},"page":"894","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Immune Suppression and Rapid Invasion of Nile Tilapia Gills Following an Acute Challenge by Flavobacterium davisii"],"prefix":"10.3390","volume":"13","author":[{"given":"Yingxuan","family":"Xu","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Xie","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Wang","sequence":"additional","affiliation":[{"name":"Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, College of Fishery, Guangdong Ocean University, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangding","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hainan Baolu Aquatic Products Technology Co., Ltd., Haikou 570208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-6363","authenticated-orcid":false,"given":"Wenlong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon Tong, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peibo","family":"Wang","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Guo","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-149X","authenticated-orcid":false,"given":"Dongdong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, School of Marine Biology and Fisheries, Collaborative Innovation Center of Marine Science and Technology, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Haikou 570228\/Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-7717","authenticated-orcid":false,"given":"Zhi","family":"Ye","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences Ocean University of China, Qingdao 266071, China"},{"name":"Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya Oceanographic Institution, Ocean University of China, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2014.03.008","article-title":"Pathogen bacteria adhesion to skin mucus of fishes","volume":"171","author":"Benhamed","year":"2014","journal-title":"Vet. 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