{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:43:45Z","timestamp":1790905425460,"version":"4.1.0"},"reference-count":91,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Junta de Andaluc\u00eda, Group no CTS-156, Spain"},{"name":"Own Funds Program of the University of M\u00e1laga"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The dorsomedial hypothalamus nucleus (DMH) plays a pivotal role in the orchestration of sympathetic nervous system activities. Through its projections to the brainstem and pontomedullary nuclei, it controls heart rate, contractility, blood pressure, and respiratory activity, such as timing and volumes. The DMH integrates inputs from higher brain centers and processes these signals in order to modulate autonomic outflow accordingly. It has been demonstrated to be of particular significance in the context of stress responses, where it orchestrates the physiological adaptations that are necessary for all adaptative responses. The perifornical region (PeF), which is closely associated with the DMH, also makes a contribution to autonomic regulation. The involvement of the PeF region in autonomic control is evidenced by its function in coordinating the autonomic and endocrine responses to stress, frequently in conjunction with the DMH. The DMH and the PeF do not function in an isolated manner; rather, they are components of a comprehensive hypothalamic network that integrates several autonomic responses. This neural network could serve as a target for developing therapeutic strategies in cardiovascular diseases.<\/jats:p>","DOI":"10.3390\/biology13110933","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T11:58:07Z","timestamp":1732017487000},"page":"933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hypothalamic Regulation of Cardiorespiratory Functions: Insights into the Dorsomedial and Perifornical Pathways"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-7633","authenticated-orcid":false,"given":"Laura","family":"Carrillo-Franco","sequence":"first","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4085-7757","authenticated-orcid":false,"given":"Marta","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Morales-Luque","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Stefan","family":"Dawid-Milner","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9023-3710","authenticated-orcid":false,"given":"Manuel V\u00edctor","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of M\u00e1laga, 29010 Malaga, Spain"},{"name":"Biomedical Research Institute of M\u00e1laga (IBIMA Plataforma BIONAND), 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102918","DOI":"10.1016\/j.autneu.2021.102918","article-title":"Central sympathetic network for thermoregulatory responses to psychological stress","volume":"237","author":"Nakamura","year":"2022","journal-title":"Auton. 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