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This study aimed to investigate the protective effects of curcumin on gut dysbiosis, gut barrier integrity, and bile acid homeostasis in aged mice fed a high-fat, high-sugar diet (HFHSD). Eighteen- to twenty-one-month-old male C57BL\/6 mice were divided into groups fed a normal chow diet or HFHSD, with or without curcumin supplementation (0.4% w\/w) for 8 and 15 weeks. We assessed body weight, food intake, insulin sensitivity, gut microbiota composition, and gene expression in the gut and liver and performed histological analysis of gut tissues. Curcumin supplementation prevented HFHSD-induced weight gain and metabolic disturbances. In the gut, curcumin-treated mice showed a higher abundance of beneficial bacterial genera, such as Lachnospiraceae, Akkermansia, Mucispirillum, and Verrucomicrobiota, alongside a lower abundance of harmful bacterial genera like Desulfobacteria, Alistipes, and Muribaculaceae compared to control. This shift in gut microbiota was associated with improved gut integrity, as demonstrated by increased expression of the tight junction protein occludin and reduced levels of the pro-inflammatory marker interleukin-1\u03b2 in the ileum. Additionally, curcumin modulated hepatic gene expression involved in bile acid homeostasis, suggesting a positive effect on liver health. Curcumin supplementation can alleviate the negative effects of aging and an HFHSD on the gut microbiome, improve gut barrier integrity, and maintain bile acid homeostasis. These findings highlight curcumin\u2019s potential as a dietary intervention for managing obesity- and age-associated gut health issues.<\/jats:p>","DOI":"10.3390\/biology13120955","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:57:54Z","timestamp":1732172274000},"page":"955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Curcumin Mitigates Gut Dysbiosis and Enhances Gut Barrier Function to Alleviate Metabolic Dysfunction in Obese, Aged Mice"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1487-7578","authenticated-orcid":false,"given":"Gopal","family":"Lamichhane","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femi","family":"Olawale","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4085-0689","authenticated-orcid":false,"given":"Da-Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0819-8982","authenticated-orcid":false,"given":"Su-Jeong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Chaffin","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanmi","family":"Alake","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-1193","authenticated-orcid":false,"given":"Edralin A.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4781-5816","authenticated-orcid":false,"given":"Guolong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Animal and Food Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine M.","family":"Egan","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD 21224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-1319","authenticated-orcid":false,"given":"Yoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 74078, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1038\/s41467-023-40874-x","article-title":"Gut Microbiota and Fecal Short Chain Fatty Acids Differ with Adiposity and Country of Origin: The METS-Microbiome Study","volume":"14","author":"Maseng","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature07540","article-title":"A Core Gut Microbiome in Obese and Lean Twins","volume":"457","author":"Turnbaugh","year":"2009","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jnutbio.2019.01.017","article-title":"Green Tea Extract Prevents Obesity in Male Mice by Alleviating Gut Dysbiosis in Association with Improved Intestinal Barrier Function That Limits Endotoxin Translocation and Adipose Inflammation","volume":"67","author":"Dey","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrgastro.2012.156","article-title":"The Role of the Gut Microbiota in Nutrition and Health","volume":"9","author":"Flint","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2100274","DOI":"10.1002\/mnfr.202100274","article-title":"Curcumin Reduces Adipose Tissue Inflammation and Alters Gut Microbiota in Diet-Induced Obese Male Mice","volume":"65","author":"Islam","year":"2021","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.phrs.2012.10.020","article-title":"The Influence of Diet on the Gut Microbiota","volume":"69","author":"Scott","year":"2013","journal-title":"Pharmacol. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s40495-019-00196-3","article-title":"Gut Microbiota, Dietary Phytochemicals, and Benefits to Human Health","volume":"5","author":"Yin","year":"2019","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.phrs.2009.11.001","article-title":"Interactions of Gut Microbiota with Functional Food Components and Nutraceuticals","volume":"61","author":"Laparra","year":"2010","journal-title":"Pharmacol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Jo, J.-K., Seo, S.-H., Park, S.-E., Kim, H.-W., Kim, E.-J., Kim, J.-S., Pyo, J.-Y., Cho, K.-M., Kwon, S.-J., and Park, D.-H. (2021). Gut Microbiome and Metabolome Profiles Associated with High-Fat Diet in Mice. Metabolites, 11.","DOI":"10.3390\/metabo11080482"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10.1128","DOI":"10.1128\/msystems.00115-21","article-title":"High-Fiber, Whole-Food Dietary Intervention Alters the Human Gut Microbiome but Not Fecal Short-Chain Fatty Acids","volume":"6","author":"Oliver","year":"2021","journal-title":"mSystems"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Campos-Perez, W., and Martinez-Lopez, E. (2021). Effects of Short Chain Fatty Acids on Metabolic and Inflammatory Processes in Human Health. Biochim. Biophys. Acta (BBA) Mol. Cell Biol. Lipids, 1866.","DOI":"10.1016\/j.bbalip.2021.158900"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xiong, R.-G., Zhou, D.-D., Wu, S.-X., Huang, S.-Y., Saimaiti, A., Yang, Z.-J., Shang, A., Zhao, C.-N., Gan, R.-Y., and Li, H.-B. (2022). Health Benefits and Side Effects of Short-Chain Fatty Acids. Foods, 11.","DOI":"10.3390\/foods11182863"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"105420","DOI":"10.1016\/j.phrs.2021.105420","article-title":"The Role of Short-Chain Fatty Acids in Intestinal Barrier Function, Inflammation, Oxidative Stress, and Colonic Carcinogenesis","volume":"165","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Malesza, I.J., Malesza, M., Walkowiak, J., Mussin, N., Walkowiak, D., Aringazina, R., Bartkowiak-Wieczorek, J., and M\u0105dry, E. (2021). High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review. Cells, 10.","DOI":"10.3390\/cells10113164"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kiran, S., Rakib, A., Kodidela, S., Kumar, S., and Singh, U.P. (2022). High-Fat Diet-Induced Dysregulation of Immune Cells Correlates with Macrophage Phenotypes and Chronic Inflammation in Adipose Tissue. Cells, 11.","DOI":"10.3390\/cells11081327"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5889","DOI":"10.7150\/thno.56157","article-title":"High Fat Diet, Gut Microbiome and Gastrointestinal Cancer","volume":"11","author":"Tong","year":"2021","journal-title":"Theranostics"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aac8469","article-title":"Gut Microbiota and Aging","volume":"350","author":"Jeffery","year":"2015","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/gerona\/glx042","article-title":"Biological Aging and the Human Gut Microbiota","volume":"72","author":"Maffei","year":"2017","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of Aging: An Expanding Universe","volume":"186","author":"Blasco","year":"2023","journal-title":"Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.arr.2017.01.001","article-title":"Gut Microbiota: A Player in Aging and a Target for Anti-Aging Intervention","volume":"35","author":"Vaiserman","year":"2017","journal-title":"Ageing Res. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12979-020-00213-w","article-title":"Gut Microbiota as the Key Controllers of \u201cHealthy\u201d Aging of Elderly People","volume":"18","author":"Ragonnaud","year":"2021","journal-title":"Immun. Ageing"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.chom.2020.07.013","article-title":"The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence","volume":"28","author":"DeJong","year":"2020","journal-title":"Cell Host Microbe"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"111079","DOI":"10.1016\/j.exger.2020.111079","article-title":"Is Inflammageing Influenced by the Microbiota in the Aged Gut? A Systematic Review","volume":"141","author":"Shintouo","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111841","DOI":"10.1016\/j.mad.2023.111841","article-title":"Improving Intestinal Inflammaging to Delay Aging? A New Perspective","volume":"214","author":"Zhang","year":"2023","journal-title":"Mech. Ageing Dev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/NT.0000000000000616","article-title":"Resiliency of the Digestive System During Aging and the Impact of Diet","volume":"58","author":"Sanders","year":"2023","journal-title":"Nutr. Today"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"112497","DOI":"10.1016\/j.exger.2024.112497","article-title":"Influence of Human Gut Microbiome on the Healthy and the Neurodegenerative Aging","volume":"194","author":"Borrego","year":"2024","journal-title":"Exp. Gerontol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Sharma, B.R., Jaiswal, S., and Ravindra, P.V. (2022). Modulation of Gut Microbiota by Bioactive Compounds for Prevention and Management of Type 2 Diabetes. Biomed. Pharmacother., 152.","DOI":"10.1016\/j.biopha.2022.113148"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Bian, Y., Lei, J., Zhong, J., Wang, B., Wan, Y., Li, J., Liao, C., He, Y., Liu, Z., and Ito, K. (2022). Kaempferol Reduces Obesity, Prevents Intestinal Inflammation, and Modulates Gut Microbiota in High-Fat Diet Mice. J. Nutr. Biochem., 99.","DOI":"10.1016\/j.jnutbio.2021.108840"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.freeradbiomed.2020.04.013","article-title":"Resveratrol Reduces Obesity in High-Fat Diet-Fed Mice via Modulating the Composition and Metabolic Function of the Gut Microbiota","volume":"156","author":"Wang","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"110270","DOI":"10.1016\/j.foodres.2021.110270","article-title":"Curcumin Alleviates High-Fat Diet-Induced Hepatic Steatosis and Obesity in Association with Modulation of Gut Microbiota in Mice","volume":"143","author":"Li","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Scazzocchio, B., Minghetti, L., and D\u2019Archivio, M. (2020). Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin. Nutrients, 12.","DOI":"10.3390\/nu12092499"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lamichhane, G., Liu, J., Lee, S.-J., Lee, D.-Y., Zhang, G., and Kim, Y. (2024). Curcumin Mitigates the High-Fat High-Sugar Diet-Induced Impairment of Spatial Memory, Hepatic Metabolism, and the Alteration of the Gut Microbiome in Alzheimer\u2019s Disease-Induced (3xTg-AD) Mice. Nutrients, 16.","DOI":"10.3390\/nu16020240"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1080\/21655979.2021.2009322","article-title":"Improvement of Intestinal Barrier Function, Gut Microbiota, and Metabolic Endotoxemia in Type 2 Diabetes Rats by Curcumin","volume":"12","author":"Huang","year":"2021","journal-title":"Bioengineered"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1039\/D4FO01489H","article-title":"Consumption of Dietary Turmeric Promotes Fat Browning and Thermogenesis in Association with Gut Microbiota Regulation in High-Fat Diet-Fed Mice","volume":"15","author":"Yang","year":"2024","journal-title":"Food Funct."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2300378","DOI":"10.1002\/mnfr.202300378","article-title":"The Dose-Dependent Effect of Curcumin Supplementation on Inflammatory Response and Gut Microbiota Profile in High-Fat Fed C57BL\/6 Mice","volume":"67","author":"Fassini","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, D.-Y., Lee, S.-J., Chandrasekaran, P., Lamichhane, G., O\u2019Connell, J.F., Egan, J.M., and Kim, Y. (2023). Dietary Curcumin Attenuates Hepatic Cellular Senescence by Suppressing the MAPK\/NF-\u03baB Signaling Pathway in Aged Mice. Antioxidants, 12.","DOI":"10.3390\/antiox12061165"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12986-019-0377-0","article-title":"Dietary Curcumin Enhances Insulin Clearance in Diet-Induced Obese Mice via Regulation of Hepatic PI3K-AKT Axis and IDE, and Preservation of Islet Integrity","volume":"16","author":"Kim","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"225","DOI":"10.18632\/aging.203821","article-title":"Dietary Curcumin Restores Insulin Homeostasis in Diet-Induced Obese Aged Mice","volume":"14","author":"Lee","year":"2022","journal-title":"Aging"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lamichhane, G., Lee, D.-Y., Franks, R., Olawale, F., Jin, J.-B., Egan, J.M., and Kim, Y. (2024). Curcumin-Rich Diet Mitigates Non-Alcoholic Fatty Liver Disease (NAFLD) by Attenuating Fat Accumulation and Improving Insulin Sensitivity in Aged Female Mice under Nutritional Stress. Biology, 13.","DOI":"10.3390\/biology13070472"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Na\u00efve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1136\/gutjnl-2012-304119","article-title":"Western Diet Induces Dysbiosis with Increased E Coli in CEABAC10 Mice, Alters Host Barrier Function Favouring AIEC Colonisation","volume":"63","author":"Denizot","year":"2014","journal-title":"Gut"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"111836","DOI":"10.1016\/j.nut.2022.111836","article-title":"Western Diet\u2013Induced Mouse Model of Non-Alcoholic Fatty Liver Disease Associated with Metabolic Outcomes: Features of Gut Microbiome-Liver-Adipose Tissue Axis","volume":"103","author":"Romualdo","year":"2022","journal-title":"Nutrition"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., and Di Ciaula, A. (2024). Metabolic Dysfunction\u2013Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115640"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"eaat4271","DOI":"10.1126\/scitranslmed.aat4271","article-title":"Commensal Bacteria Contribute to Insulin Resistance in Aging by Activating Innate B1a Cells","volume":"10","author":"Bodogai","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Smith, B.J., Hatter, B., Washburn, K., Graef-Downard, J., Ojo, B.A., El-Rassi, G.D., Cichewicz, R.H., Payton, M., and Lucas, E.A. (2022). Dried Plum\u2019s Polyphenolic Compounds and Carbohydrates Contribute to Its Osteoprotective Effects and Exhibit Prebiotic Activity in Estrogen Deficient C57bl\/6 Mice. Nutrients, 14.","DOI":"10.3390\/nu14091685"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.appet.2011.01.016","article-title":"Propionate. Anti-Obesity and Satiety Enhancing Factor?","volume":"56","author":"Arora","year":"2011","journal-title":"Appetite"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.ajcnut.2023.03.006","article-title":"The Effect of Curcumin Supplementation on Weight Loss and Anthropometric Indices: An Umbrella Review and Updated Meta-Analyses of Randomized Controlled Trials","volume":"117","author":"Unhapipatpong","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"919","DOI":"10.3945\/jn.108.100966","article-title":"Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57\/BL Mice","volume":"139","author":"Ejaz","year":"2009","journal-title":"J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Panah, F.M., Nielsen, K.D., Simpson, G.L., Sch\u00f6nherz, A., Schramm, A., Lauridsen, C., Nielsen, T.S., H\u00f8jberg, O., Fredborg, M., and Purup, S. (2023). A Westernized Diet Changed the Colonic Bacterial Composition and Metabolite Concentration in a Dextran Sulfate Sodium Pig Model for Ulcerative Colitis. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1238157"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00018-017-2509-x","article-title":"Mechanisms and Consequences of Intestinal Dysbiosis","volume":"74","author":"Weiss","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12753","DOI":"10.1021\/acs.jafc.1c05793","article-title":"In Vitro and in Vivo Studies Reveal That Hesperetin-7-O-Glucoside, a Naturally Occurring Monoglucoside, Exhibits Strong Anti-Inflammatory Capacity","volume":"69","author":"Wu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"103390","DOI":"10.1016\/j.eti.2023.103390","article-title":"Dictyophora Polysaccharides Alleviate Intestinal-Hepatic Injury Exposed to Low-Arsenic by Regulating the Imbalance of Gut Microbiota and LPS\/TLR4 Pathway in Rats","volume":"32","author":"Zuo","year":"2023","journal-title":"Environ. Technol. Innov."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s41385-021-00389-4","article-title":"Human Gut-Associated Lymphoid Tissues (GALT); Diversity, Structure, and Function","volume":"14","author":"Fenton","year":"2021","journal-title":"Mucosal Immunol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4196\/kjpp.2016.20.2.147","article-title":"Curcumin Protects against the Intestinal Ischemia-Reperfusion Injury: Involvement of the Tight Junction Protein ZO-1 and TNF-\u03b1 Related Mechanism","volume":"20","author":"Tian","year":"2016","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","article-title":"Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders","volume":"159","author":"Chopyk","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Yang, F., Tang, X., Ding, L., Zhou, Y., Yang, Q., Gong, J., Wang, G., Wang, Z., and Yang, L. (2016). Curcumin Protects ANIT-Induced Cholestasis through Signaling Pathway of FXR-Regulated Bile Acid and Inflammation. Sci. Rep., 6.","DOI":"10.1038\/srep33052"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/13\/12\/955\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:36:24Z","timestamp":1760114184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/13\/12\/955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":58,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["biology13120955"],"URL":"https:\/\/doi.org\/10.3390\/biology13120955","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]}}}