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However, their practical utilization is unsatisfactory due to high costs and processing difficulties. Broussonetia papyrifera is a plant material that has shown the potential to inhibit the reproduction of Microtus fortis, a species that causes serious damage to crops in the Dongting Lake region in China. M. fortis was treated with different doses of B. papyrifera leaf methanol extracts. The results show that the growth of sex organs was inhibited, and the males\u2019 testosterone levels and sperm quality were reduced. Though there were some positive effects on females, the reproductive parameters of coupled voles were inferior; the most treated couple exhibited an increased reproductive time, fetal counts, and reduced weight. It was also found that M. fortis responded negatively to the extract after a single treatment or long-term repeated treatment compared to a short-term repeated treatment. B. papyrifera leaves showed a higher application potential as a sterilant for male rodents. These findings enrich the study of plant sterilants and provide insights into the utilization of B. papyrifera and the management of rodents. Owing to the effectiveness and accessibility of the leaves, the derived sterilant may be more economical for controlling rodent pests.<\/jats:p>","DOI":"10.3390\/biology14010056","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T07:40:08Z","timestamp":1736754008000},"page":"56","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Broussonetia papyrifera Extract Can Be Used as a Raw Material Source for a Sterility Agent for Microtus fortis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5055-0161","authenticated-orcid":false,"given":"Shuangye","family":"Wang","sequence":"first","affiliation":[{"name":"The Central Laboratory of Medical Molecular Biology, School of Basic Medicine, Guiyang Healthcare Vocational University, Guiyang 550081, China"},{"name":"Hunan Engineering Research Center of Ecological Environment Intelligent Monitoring and Disaster Prevention and Mitigation Technology in Dongting Lake Region, College of Information and Electronic Engineering, Hunan City University, Yiyang 413000, China"},{"name":"Hunan Research Center of Engineering Technology for Utilization of Environmental and Resources Plant, Central South University of Forestry and Technology, Changsha 410004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Lan","sequence":"additional","affiliation":[{"name":"Key Laboratory of National Forestry and Grassland Administration on Management of Western Forest Bio-Disaster, College of Forestry, Northwest A & F University, Yangling 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Hunan Research Center of Engineering Technology for Utilization of Environmental and Resources Plant, Central South University of Forestry and Technology, Changsha 410004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanfu","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Research Center of Engineering Technology for Utilization of Environmental and Resources Plant, Central South University of Forestry and Technology, Changsha 410004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Engineering Research Center of Ecological Environment Intelligent Monitoring and Disaster Prevention and Mitigation Technology in Dongting Lake Region, College of Information and Electronic Engineering, Hunan City University, Yiyang 413000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dongting Lake Station for Wetland Ecosystem Research, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha 410125, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Hunan Engineering Research Center of Ecological Environment Intelligent Monitoring and Disaster Prevention and Mitigation Technology in Dongting Lake Region, College of Information and Electronic Engineering, Hunan City University, Yiyang 413000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7401-5163","authenticated-orcid":false,"given":"Zhenggang","family":"Xu","sequence":"additional","affiliation":[{"name":"Hunan Engineering Research Center of Ecological Environment Intelligent Monitoring and Disaster Prevention and Mitigation Technology in Dongting Lake Region, College of Information and Electronic Engineering, Hunan City University, Yiyang 413000, China"},{"name":"Hunan Research Center of Engineering Technology for Utilization of Environmental and Resources Plant, Central South University of Forestry and Technology, Changsha 410004, China"},{"name":"Key Laboratory of National Forestry and Grassland Administration on Management of Western Forest Bio-Disaster, College of Forestry, Northwest A & F University, Yangling 712100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/hdy.2011.110","article-title":"Chromosomal evolution in Rodentia","volume":"108","author":"Romanenko","year":"2012","journal-title":"Heredity"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"D\u00edaz, J.C., Song, Y., Moore, A., Borchert, J.N., and Kohn, M.H. 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