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Current treatments, including bisphosphonates and calcium supplementation, are limited by adverse effects and incomplete efficacy. Emerging research highlights ferroptosis\u2014an iron-dependent cell death driven by lipid peroxidation\u2014as a critical contributor to OP pathogenesis, characterized by dysregulated iron metabolism, oxidative stress, and lipid peroxide accumulation, which disrupt bone remodeling by impairing osteoblast function and enhancing osteoclast activity. This review elucidates the mechanistic interplay between ferroptosis and OP subtypes (diabetic osteoporosis (DOP), glucocorticoid-induced (GIOP), and postmenopausal osteoporosis (PMOP)) and evaluates the efficacy of Chinese herbal interventions in mitigating ferroptosis-driven bone loss. Key findings reveal that excess iron exacerbates lipid peroxidation via the Fenton reaction, while glutathione peroxidase 4 (GPX4) inactivation and system Xc- inhibition amplify oxidative damage. In DIOP, hyperglycemia-induced ROS and advanced glycation end products suppress osteogenesis, countered by melatonin and naringenin via nuclear factor -related factor 2 (Nrf2)\/GPX4 activation. GIOP involves dexamethasone-mediated GPX4 downregulation, mitigated by exosomes and melatonin through phosphatidylinositol 3-kinase (PI3K)\/protein kinase B (AKT)\/mammalian target of rapamycin (mTOR) signaling. PMOP driven by estrogen deficiency-induced iron overload is alleviated by aconitine and icariin (ICA) via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-\u03baB) and signal transducer and activator of transcription 3 (STAT3) pathways. Chinese herbs, including active compounds (quercetin, gastrodin, ICA, etc.) and formulations (Bugu Shengsui Capsule, Erxian Decoction (EXD), etc.), regulate iron metabolism, enhance antioxidant defenses (Nrf2\/heme oxygenase 1(HO-1)), and inhibit lipid peroxidation, effectively restoring bone homeostasis. These findings underscore ferroptosis as a pivotal mechanism in OP progression and highlight the therapeutic promise of Chinese herbs in bridging traditional medicine with modern mechanistic insights. Future research should prioritize elucidating precise molecular targets, optimizing formulations, and validating clinical efficacy to address current therapeutic gaps.<\/jats:p>","DOI":"10.3390\/biology14040367","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T07:47:44Z","timestamp":1743580064000},"page":"367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Role of Ferroptosis in Osteoporosis and Advances in Chinese Herbal Interventions"],"prefix":"10.3390","volume":"14","author":[{"given":"Pan","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Innovation Practice Center, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-Xue","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ling","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Shuang","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Zhu","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Lin","family":"Dai","sequence":"additional","affiliation":[{"name":"Ginseng Scientific Research Institute, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[{"name":"Innovation and Entrepreneurship College, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41413-023-00264-x","article-title":"Modulation of Bone Remodeling by the Gut Microbiota: A New Therapy for Osteoporosis","volume":"11","author":"Lyu","year":"2023","journal-title":"Bone Res."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Adolpho, L.F., Gomes, M.P.O., Freitas, G.P., Bighetti-Trevisan, R.L., Ramos, J.I.R., Campeoti, G.H., Zatta, G.C., Almeida, A.L.G., Tarone, A.G., and Marostica-Junior, M.R. (2024). Jaboticaba Peel Extract Attenuates Ovariectomy-Induced Bone Loss by Preserving Osteoblast Activity. Biology, 13.","DOI":"10.3390\/biology13070526"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0140-6736(76)92217-0","article-title":"Long-Term Prevention of Postmenopausal Osteoporosis by \u0152strogen","volume":"307","author":"Lindsay","year":"1976","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.2174\/0929867327666200330142432","article-title":"Osteoporosis: Mechanism, Molecular Target and Current Status on Drug Development","volume":"28","author":"Li","year":"2021","journal-title":"Curr. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00198-015-3386-5","article-title":"Calcium plus Vitamin D Supplementation and Risk of Fractures: An Updated Meta-Analysis from the National Osteoporosis Foundation","volume":"27","author":"Weaver","year":"2016","journal-title":"Osteoporos. Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.4065\/83.9.1032","article-title":"Bisphosphonates: Mechanism of Action and Role in Clinical Practice","volume":"83","author":"Drake","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2165\/00003495-200161070-00010","article-title":"Alendronate","volume":"61","author":"Sharpe","year":"2001","journal-title":"Drugs"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/01926230490462138","article-title":"Bone Neoplasms in F344 Rats Given Teriparatide [rhPTH(1-34)] Are Dependent on Duration of Treatment and Dose","volume":"32","author":"Vahle","year":"2004","journal-title":"Toxicol. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"10359","DOI":"10.18632\/aging.103262","article-title":"Resveratrol Promotes Osteogenesis and Alleviates Osteoporosis by Inhibiting P53","volume":"12","author":"Yu","year":"2020","journal-title":"Aging"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bao, J., Yan, Y., Zuo, D., Zhuo, Z., Sun, T., Lin, H., Han, Z., Zhao, Z., and Yu, H. (2023). Iron Metabolism and Ferroptosis in Diabetic Bone Loss: From Mechanism to Therapy. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1178573"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9500","DOI":"10.18632\/aging.103223","article-title":"MiR-16-5p Regulates Postmenopausal Osteoporosis by Directly Targeting VEGFA","volume":"12","author":"Yu","year":"2020","journal-title":"Aging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111598","DOI":"10.1016\/j.cellsig.2025.111598","article-title":"Mechanisms of Ferroptosis in Bone Disease: A New Target for Osteoporosis Treatment","volume":"127","author":"Wang","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s40266-018-0525-7","article-title":"Denosumab: A Review in Postmenopausal Osteoporosis","volume":"35","author":"Deeks","year":"2018","journal-title":"Drugs Aging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.bbagen.2019.06.010","article-title":"Iron Homeostasis and Iron-Regulated ROS in Cell Death, Senescence and Human Diseases","volume":"1863","author":"Nakamura","year":"2019","journal-title":"Biochim. Et Biophys. Acta (BBA)\u2014Gen. Subj."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41581-019-0197-5","article-title":"The Multifaceted Role of Iron in Renal Health and Disease","volume":"16","author":"Wetzels","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"155312","DOI":"10.1016\/j.prp.2024.155312","article-title":"Advances in Exosome Modulation of Ferroptosis for the Treatment of Orthopedic Diseases","volume":"257","author":"Cui","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, D. (2023). Progress in the Study of Ferroptosis in Cancer Treatment: State-of-the-Art. Chem.-Biol. Interact., 371.","DOI":"10.1016\/j.cbi.2023.110348"},{"key":"ref_18","first-page":"785","article-title":"Ferroptotic Cell Death: New Regulatory Mechanisms for Metabolic Diseases","volume":"21","author":"Le","year":"2021","journal-title":"Endocrine, Metab. Immune Disord. Drug Targets"},{"key":"ref_19","first-page":"111836","article-title":"Ferroptosis\u2014A New Target of Osteoporosis","volume":"165","author":"Gao","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","article-title":"DHODH-Mediated Ferroptosis Defence Is a Targetable Vulnerability in Cancer","volume":"593","author":"Mao","year":"2021","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wen, S., Aki, T., Unuma, K., and Uemura, K. (2020). Chemically Induced Models of Parkinson\u2019s Disease: History and Perspectives for the Involvement of Ferroptosis. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.581191"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00223-013-9817-4","article-title":"Therapeutic Effect of Deferoxamine on Iron Overload-Induced Inhibition of Osteogenesis in a Zebrafish Model","volume":"94","author":"Chen","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"15668","DOI":"10.1002\/jcp.28217","article-title":"Iron Overload Threatens the Growth of Osteoblast Cells via Inhibiting the PI3K\/AKT\/FOXO3a\/DUSP14 Signaling Pathway","volume":"234","author":"Xia","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s12011-019-01867-4","article-title":"The Effect of Abnormal Iron Metabolism on Osteoporosis","volume":"195","author":"Che","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3324\/haematol.2016.144808","article-title":"Wnt5a Is a Key Target for the Pro-Osteogenic Effects of Iron Chelation on Osteoblast Progenitors","volume":"101","author":"Baschant","year":"2016","journal-title":"Haematologica"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2147\/DDDT.S161086","article-title":"Comparison of the Effects of Deferasirox, Deferoxamine, and Combination of Deferasirox and Deferoxamine on an Aplastic Anemia Mouse Model Complicated with Iron Overload","volume":"12","author":"Wu","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wang, J., Chen, T., and Gao, F. (2024). Mechanism and Application Prospect of Ferroptosis Inhibitors in Improving Osteoporosis. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1492610"},{"key":"ref_28","first-page":"815","article-title":"[Salvianolic Acid B Promotes the Proliferation, Migration and Osteogenic Differentiation of Human Gingival Mesenchymal Stem Cells by Activating the PI3K\/AKT Pathway]","volume":"37","author":"Yao","year":"2021","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi = Chin. J. Cell. Mol. Immunol."},{"key":"ref_29","first-page":"23","article-title":"Effect of Desferrioxamine and Deferiprone (L1) on the Proliferation of MG-63 Bone Cells and on Phosphatase Alkaline Activity","volume":"13","author":"Diaz","year":"1998","journal-title":"Nephrol. Dial. Transplant. Off. Publ. Eur. Dial. Transpl. Assoc.\u2014Eur. Ren. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3324\/haematol.2009.016824","article-title":"Deferasirox Is a Powerful NF-kappaB Inhibitor in Myelodysplastic Cells and in Leukemia Cell Lines Acting Independently from Cell Iron Deprivation by Chelation and Reactive Oxygen Species Scavenging","volume":"95","author":"Messa","year":"2010","journal-title":"Haematologica"},{"key":"ref_31","first-page":"1011","article-title":"[Melatonin Promotes Osteogenesis of Bone Marrow Mesenchymal Stem Cells by Improving the Inflammatory State in Ovariectomized Rats]","volume":"37","author":"Guan","year":"2023","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi = Zhongguo Xiufu Chongjian Waike Zazhi = Chin. J. Reparative Reconstr. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/iub.2656","article-title":"Iron Overload-induced Ferroptosis of Osteoblasts Inhibits Osteogenesis and Promotes Osteoporosis: An in Vitro and in Vivo Study","volume":"74","author":"Jiang","year":"2022","journal-title":"IUBMB Life"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.freeradbiomed.2022.11.013","article-title":"VDR Activation Attenuates Osteoblastic Ferroptosis and Senescence by Stimulating the Nrf2\/GPX4 Pathway in Age-Related Osteoporosis","volume":"193","author":"Xu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_34","first-page":"2634431","article-title":"Ferroptosis: A New Regulatory Mechanism in Osteoporosis","volume":"2022","author":"Liu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"154768","DOI":"10.1016\/j.phymed.2023.154768","article-title":"Therapeutic Application of Natural Products: NAD+ Metabolism as Potential Target","volume":"114","author":"Guo","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lim, J.-M., Yoo, H.J., and Lee, K.-W. (2022). High Molecular Weight Fucoidan Restores Intestinal Integrity by Regulating Inflammation and Tight Junction Loss Induced by Methylglyoxal-Derived Hydroimidazolone-1. Mar. Drugs, 20.","DOI":"10.3390\/md20090580"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"115031","DOI":"10.1016\/j.ejmech.2022.115031","article-title":"Natural Product Evodiamine-Inspired Medicinal Chemistry: Anticancer Activity, Structural Optimization and Structure-Activity Relationship","volume":"247","author":"Wang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and Transferrin Regulate Ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: Molecular Mechanisms and Health Implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"12223","DOI":"10.1021\/ic400484n","article-title":"Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease","volume":"52","author":"Theil","year":"2013","journal-title":"Inorg. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1186\/s13046-019-1397-3","article-title":"Iron and Leukemia: New Insights for Future Treatments","volume":"38","author":"Wang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tem.2021.04.010","article-title":"Ferritinophagy and Ferroptosis in the Management of Metabolic Diseases","volume":"32","author":"Ajoolabady","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy Promotes Ferroptosis by Degradation of Ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/cr.2016.95","article-title":"Ferroptosis Is an Autophagic Cell Death Process","volume":"26","author":"Gao","year":"2016","journal-title":"Cell Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tcb.2020.02.009","article-title":"Emerging Mechanisms and Disease Relevance of Ferroptosis","volume":"30","author":"Stockwell","year":"2020","journal-title":"Trends Cell Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.devcel.2019.10.007","article-title":"Prominin2 Drives Ferroptosis Resistance by Stimulating Iron Export","volume":"51","author":"Brown","year":"2019","journal-title":"Dev. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"5005136","DOI":"10.1155\/2021\/5005136","article-title":"Ferroptosis Mediated by Lipid Reactive Oxygen Species: A Possible Causal Link of Neuroinflammation to Neurological Disorders","volume":"2021","author":"Cheng","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"101899","DOI":"10.1016\/j.arr.2023.101899","article-title":"Inhibition of Ferroptosis through Regulating Neuronal Calcium Homeostasis: An Emerging Therapeutic Target for Alzheimer\u2019s Disease","volume":"87","author":"Sun","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Vitalakumar, D., Sharma, A., and Flora, S.J.S. (2021). Ferroptosis: A Potential Therapeutic Target for Neurodegenerative Diseases. J. Biochem. Mol. Tox, 35.","DOI":"10.1002\/jbt.22830"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1002\/jcp.26954","article-title":"Ferritinophagy\/Ferroptosis: Iron-related Newcomers in Human Diseases","volume":"233","author":"Tang","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"104919","DOI":"10.1016\/j.phrs.2020.104919","article-title":"The Application of Ferroptosis in Diseases","volume":"159","author":"Qiu","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1101\/lm.052282.120","article-title":"Iron-Responsive-like Elements and Neurodegenerative Ferroptosis","volume":"27","author":"Rogers","year":"2020","journal-title":"Learn. Mem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Chen, Y., Guo, X., Zeng, Y., Mo, X., Hong, S., He, H., Li, J., Fatima, S., and Liu, Q. (2023). Oxidative Stress Induces Mitochondrial Iron Overload and Ferroptotic Cell Death. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-42760-4"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial Oxidative Stress Mediated Fe-Induced Ferroptosis via the NRF2-ARE Pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/cbin.11505","article-title":"\u03b1-Lipoic Acid Alleviates Ferroptosis in the MPP+-induced PC12 Cells via Activating the PI3K\/Akt\/Nrf2 Pathway","volume":"45","author":"Liu","year":"2021","journal-title":"Cell Biol. Int."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Li, J., Li, M., Ge, Y., Chen, J., Ma, J., Wang, C., Sun, M., Wang, L., Yao, S., and Yao, C. (2022). \u03b2-Amyloid Protein Induces Mitophagy-Dependent Ferroptosis through the CD36\/PINK\/PARKIN Pathway Leading to Blood\u2013Brain Barrier Destruction in Alzheimer\u2019s Disease. Cell Biosci., 12.","DOI":"10.1186\/s13578-022-00807-5"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/s41467-019-09277-9","article-title":"A GPX4-Dependent Cancer Cell State Underlies the Clear-Cell Morphology and Confers Sensitivity to Ferroptosis","volume":"10","author":"Zou","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"113944","DOI":"10.1016\/j.ecoenv.2022.113944","article-title":"4-Tert-Butylphenol Triggers Common Carp Hepatocytes Ferroptosis via Oxidative Stress, Iron Overload, SLC7A11\/GSH\/GPX4 Axis, and ATF4\/HSPA5\/GPX4 Axis","volume":"242","author":"Cui","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1007\/s12035-018-1403-3","article-title":"Ferroptosis and Its Role in Diverse Brain Diseases","volume":"56","author":"Weiland","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-020-00428-9","article-title":"Ferroptosis: Mechanisms and Links with Diseases","volume":"6","author":"Yan","year":"2021","journal-title":"Sig Transduct. Target. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"e13158","DOI":"10.1111\/cpr.13158","article-title":"Sorafenib Attenuates Liver Fibrosis by Triggering Hepatic Stellate Cell Ferroptosis via HIF-1\u03b1\/SLC7A11 Pathway","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"630","DOI":"10.20892\/j.issn.2095-3941.2019.0158","article-title":"The Crosstalk between Autophagy and Ferroptosis: What Can We Learn to Target Drug Resistance in Cancer?","volume":"16","author":"Zhou","year":"2019","journal-title":"Cancer Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s10020-023-00724-4","article-title":"Acid Sphingomyelinase Mediates Ferroptosis Induced by High Glucose via Autophagic Degradation of GPX4 in Type 2 Diabetic Osteoporosis","volume":"29","author":"Du","year":"2023","journal-title":"Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-3-030-62026-4_4","article-title":"The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis","volume":"1301","author":"Gikandi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bbrc.2018.12.039","article-title":"Lipid Storage and Lipophagy Regulates Ferroptosis","volume":"508","author":"Bai","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"eaaw2238","DOI":"10.1126\/sciadv.aaw2238","article-title":"Clockophagy Is a Novel Selective Autophagy Process Favoring Ferroptosis","volume":"5","author":"Yang","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1002\/jcp.30331","article-title":"Exosomes Derived from Vascular Endothelial Cells Antagonize Glucocorticoid-induced Osteoporosis by Inhibiting Ferritinophagy with Resultant Limited Ferroptosis of Osteoblasts","volume":"236","author":"Yang","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12020-018-1548-x","article-title":"Efficacy of Anti-Osteoporotic Medications in Patients with Type 1 and 2 Diabetes Mellitus: A Systematic Review","volume":"60","author":"Anagnostis","year":"2018","journal-title":"Endocrine"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jbmr.2106","article-title":"In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes","volume":"29","author":"Farr","year":"2014","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bone.2008.03.017","article-title":"Diabetes and Fragility Fractures\u2014A Burgeoning Epidemic?","volume":"43","author":"Epstein","year":"2008","journal-title":"Bone"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nrendo.2016.153","article-title":"Mechanisms of Diabetes Mellitus-Induced Bone Fragility","volume":"13","author":"Napoli","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_74","first-page":"7608964","article-title":"Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility","volume":"2020","author":"Cairoli","year":"2020","journal-title":"J. Diabetes Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"9067610","DOI":"10.1155\/2020\/9067610","article-title":"Melatonin Suppresses Ferroptosis Induced by High Glucose via Activation of the Nrf2\/HO-1 Signaling Pathway in Type 2 Diabetic Osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-022-00198-w","article-title":"Targeting Ferroptosis Suppresses Osteocyte Glucolipotoxicity and Alleviates Diabetic Osteoporosis","volume":"10","author":"Yang","year":"2022","journal-title":"Bone Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Ji, C., Wang, Y.-N., Liu, S., Wang, M., Xu, X., and Zhang, D. (2022). Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis. Cells, 11.","DOI":"10.3390\/cells11162560"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kr\u00fcmmel, B., von Hanstein, A.-S., Pl\u00f6tz, T., Lenzen, S., and Mehmeti, I. (2022). Differential Effects of Saturated and Unsaturated Free Fatty Acids on Ferroptosis in Rat \u03b2-Cells. J. Nutr. Biochem., 106.","DOI":"10.1016\/j.jnutbio.2022.109013"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101470","DOI":"10.1016\/j.molmet.2022.101470","article-title":"Ferroptosis and Ferritinophagy in Diabetes Complications","volume":"60","author":"He","year":"2022","journal-title":"Mol. Metab."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"113373","DOI":"10.1016\/j.ecoenv.2022.113373","article-title":"Exposure to Low-Dose Cadmium Induces Testicular Ferroptosis","volume":"234","author":"Xiong","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1021\/acs.jafc.2c05632","article-title":"A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK\/SIRT1 Pathway in Type 2 Diabetic Osteoporosis","volume":"71","author":"Jin","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"155342","DOI":"10.1016\/j.phymed.2024.155342","article-title":"Poliumoside Protects against Type 2 Diabetes-Related Osteoporosis by Suppressing Ferroptosis via Activation of the Nrf2\/GPX4 Pathway","volume":"125","author":"Xu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41574-020-0341-0","article-title":"Pathogenesis of Glucocorticoid-Induced Osteoporosis and Options for Treatment","volume":"16","author":"Chotiyarnwong","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2017.10.010","article-title":"Therapeutic Mechanisms of Glucocorticoids","volume":"29","author":"Vandewalle","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/jama.1955.02950210007003","article-title":"Studies on Metacortandralone and Metacortandracin in Rheumatoid Arthritis; Antirheumatic Potency, Metabolic Effects, and Hormonal Properties","volume":"157","author":"Bunim","year":"1955","journal-title":"JAMA"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41584-020-0370-z","article-title":"Views on Glucocorticoid Therapy in Rheumatology: The Age of Convergence","volume":"16","author":"Buttgereit","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nrrheum.2014.188","article-title":"Glucocorticoid-Induced Osteoporosis: Who to Treat with What Agent?","volume":"11","author":"Rizzoli","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12020-018-1588-2","article-title":"Glucocorticoid-Induced Osteoporosis: An Update","volume":"61","author":"Compston","year":"2018","journal-title":"Endocrine"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1359\/jbmr.2000.15.6.993","article-title":"Use of Oral Corticosteroids and Risk of Fractures","volume":"15","author":"Leufkens","year":"2000","journal-title":"J. Bone Miner. Res. Off. J. Am. Soc. Bone Miner. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ Oxidoreductase FSP1 Acts Parallel to GPX4 to Inhibit Ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Lu, J., Yang, J., Zheng, Y., Chen, X., and Fang, S. (2019). Extracellular Vesicles from Endothelial Progenitor Cells Prevent Steroid-Induced Osteoporosis by Suppressing the Ferroptotic Pathway in Mouse Osteoblasts Based on Bioinformatics Evidence. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-52513-x"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbrc.2022.02.112","article-title":"Dexamethasone Induces Ferroptosis via P53\/SLC7A11\/GPX4 Pathway in Glucocorticoid-Induced Osteonecrosis of the Femoral Head","volume":"602","author":"Sun","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"113872","DOI":"10.1016\/j.ecoenv.2022.113872","article-title":"Ferroptosis Is Partially Responsible for Dexamethasone-Induced T Cell Ablation, but Not Osteoporosis in Larval Zebrafish","volume":"242","author":"Miao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_94","first-page":"8223737","article-title":"Melatonin Inhibits the Ferroptosis Pathway in Rat Bone Marrow Mesenchymal Stem Cells by Activating the PI3K\/AKT\/mTOR Signaling Axis to Attenuate Steroid-Induced Osteoporosis","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bone.2008.08.107","article-title":"Role of Iron Metabolism and Oxidative Damage in Postmenopausal Bone Loss","volume":"43","author":"Cristofaro","year":"2008","journal-title":"Bone"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.maturitas.2013.07.015","article-title":"Comparative Evaluation of Serum Levels of Main Minerals and Postmenopausal Osteoporosis","volume":"76","author":"Okyay","year":"2013","journal-title":"Maturitas"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1631\/jzus.B2200519","article-title":"Iron Accumulation and Its Impact on Osteoporotic Fractures in Postmenopausal Women","volume":"24","author":"Cai","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10753-023-01896-1","article-title":"Suppression of IRF9 Promotes Osteoclast Differentiation by Decreased Ferroptosis via STAT3 Activation","volume":"47","author":"Lan","year":"2024","journal-title":"Inflammation"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Xue, C., Luo, H., Wang, L., Deng, Q., Kui, W., Da, W., Chen, L., Liu, S., Xue, Y., and Yang, J. (2023). Aconine Attenuates Osteoclast-Mediated Bone Resorption and Ferroptosis to Improve Osteoporosis via Inhibiting NF-\u03baB Signaling. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1234563"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e2307388","DOI":"10.1002\/advs.202307388","article-title":"Ferroptosis in Osteocytes as a Target for Protection Against Postmenopausal Osteoporosis","volume":"11","author":"Jiang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"121326","DOI":"10.1016\/j.lfs.2022.121326","article-title":"Quercetin Protects against Iron Overload-Induced Osteoporosis through Activating the Nrf2\/HO-1 Pathway","volume":"322","author":"Xiao","year":"2023","journal-title":"Life Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"120601","DOI":"10.1016\/j.carbpol.2023.120601","article-title":"Structural Characterization and Anti-Osteoporosis Effects of Polysaccharide Purified from Eucommia Ulmoides Oliver Cortex Based on Its Modulation on Bone Metabolism","volume":"306","author":"Song","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Song, J., Zhang, Y., Jin, X., Zhu, Y., Li, Y., and Hu, M. (2024). Eucommia Ulmoides Oliver Polysaccharide Alleviates Glucocorticoid-Induced Osteoporosis by Stimulating Bone Formation via ERK\/BMP-2\/SMAD Signaling. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-80859-4"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e70288","DOI":"10.1111\/jcmm.70288","article-title":"Aucubin Promotes BMSCs Proliferation and Differentiation of Postmenopausal Osteoporosis Patients by Regulating Ferroptosis and BMP2 Signalling","volume":"29","author":"Zheng","year":"2025","journal-title":"J. Cell. Mol. Medi"},{"key":"ref_105","first-page":"2059","article-title":"Gastrodin Protects MC3T3-E1 Osteoblasts from Dexamethasone-Induced Cellular Dysfunction and Promotes Bone Formation via Induction of the NRF2 Signaling Pathway","volume":"41","author":"Liu","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11528","DOI":"10.18632\/oncotarget.23936","article-title":"Gastrodin Alleviates Glucocorticoid Induced Osteoporosis in Rats via Activating the Nrf2 Signaling Pathways","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"116467","DOI":"10.1016\/j.jep.2023.116467","article-title":"The Processing Methods, Phytochemistry and Pharmacology of Gastrodia Elata Bl.: A Comprehensive Review","volume":"314","author":"Su","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"176244","DOI":"10.1016\/j.ejphar.2023.176244","article-title":"Icariin Inhibits Osteoblast Ferroptosis via Nrf2\/HO-1 Signaling and Enhances Healing of Osteoporotic Fractures","volume":"965","author":"Xiang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"17370","DOI":"10.18632\/aging.203227","article-title":"Baicalein Ameliorates Osteoporosis via AKT\/FOXO1 Signaling","volume":"13","author":"Cai","year":"2021","journal-title":"Aging"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"154330","DOI":"10.1016\/j.phymed.2022.154330","article-title":"Naringenin Protects against Iron Overload-Induced Osteoarthritis by Suppressing Oxidative Stress","volume":"105","author":"Pan","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00223-015-9999-z","article-title":"Mechanical Loading Reduces Inflammation-Induced Human Osteocyte-to-Osteoclast Communication","volume":"97","author":"Pathak","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"115835","DOI":"10.1016\/j.jep.2022.115835","article-title":"Er-Xian Decoction Attenuates Ovariectomy-Induced Osteoporosis by Modulating Fatty Acid Metabolism and IGF1\/PI3K\/AKT Signaling Pathway","volume":"301","author":"Ma","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Wei, X., Qi, B., Ma, R., Zhang, Y., Liu, N., Fang, S., Zhu, Y., Xie, Y., Dai, J., and Zhu, L. (2022). Quantitative Proteomics Revealed the Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblast Proliferation. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.833474"},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Liu, N., Qi, B., Zhang, Y., Fang, S., Sun, C., Li, Q., and Wei, X. (2022). Bu-Gu-Sheng-Sui Decoction Promotes Osteogenesis via Activating the ERK\/Smad Signaling Pathways. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.976121"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Jin, W., Zhu, X., Yao, F., Xu, X., Chen, X., Luo, Z., Zhao, D., Li, X., Leng, X., and Sun, L. (2020). Cytoprotective Effect of Fufang Lurong Jiangu Capsule against Hydrogen Peroxide-Induced Oxidative Stress in Bone Marrow Stromal Cell-Derived Osteoblasts through the Nrf2\/HO-1 Signaling Pathway. Biomed. Pharmacother., 121.","DOI":"10.1016\/j.biopha.2019.109676"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Chen, X., Li, Y., Zhang, Z., Chen, L., Liu, Y., Huang, S., and Zhang, X. (2022). Xianling Gubao Attenuates High Glucose-Induced Bone Metabolism Disorder in MG63 Osteoblast-like Cells. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0276328"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Hao, J., Bei, J., Li, Z., Han, M., Ma, B., Ma, P., and Zhou, X. (2022). Qing\u2019e Pill Inhibits Osteoblast Ferroptosis via ATM Serine\/Threonine Kinase (ATM) and the PI3K\/AKT Pathway in Primary Osteoporosis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.902102"},{"key":"ref_118","first-page":"777","article-title":"Effect of Zuogui Pill on Iron Overload in Osteoporosis Model Rats","volume":"59","author":"Liu","year":"2018","journal-title":"Chin. J. Tradit. Chin. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13020-021-00482-7","article-title":"Traditional Application and Modern Pharmacological Research of Eucommia Ulmoides Oliv","volume":"16","author":"Huang","year":"2021","journal-title":"Chin. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jep.2013.11.023","article-title":"Eucommia Ulmoides Oliv.: Ethnopharmacology, Phytochemistry and Pharmacology of an Important Traditional Chinese Medicine","volume":"151","author":"He","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Sun, Y., Zhang, Y., Sun, M., Gao, W., He, Y., Wang, Y., Yang, B., Kuang, H., Sun, Y., and Zhang, Y. (2024). Advances in Eucommia Ulmoides Polysaccharides: Extraction, Purification, Structure, Bioactivities and Applications. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1421662"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2174\/0113892010265000230928060645","article-title":"Research Progress of Eucommia Ulmoides Oliv and Predictive Analysis of Quality Markers Based on Network Pharmacology","volume":"25","author":"Zhao","year":"2024","journal-title":"CPB"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e24851","DOI":"10.1016\/j.heliyon.2024.e24851","article-title":"A Review of \u201cPlant Gold\u201d Eucommia Ulmoides Oliv.: A Medicinal and Food Homologous Plant with Economic Value and Prospect","volume":"10","author":"Bao","year":"2024","journal-title":"Heliyon"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3641317","DOI":"10.1155\/2021\/3641317","article-title":"The Aqueous Extract of Eucommia Leaves Promotes Proliferation, Differentiation, and Mineralization of Osteoblast-Like MC3T3-E1 Cells","volume":"2021","author":"Guan","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1142\/S0192415X14500104","article-title":"Du-Zhong (Eucommia Ulmoides) Prevents Disuse-Induced Osteoporosis in Hind Limb Suspension Rats","volume":"42","author":"Pan","year":"2014","journal-title":"Am. J. Chin. Med."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Wang, T., Fan, L., Feng, S., Ding, X., An, X., Chen, J., Wang, M., Zhai, X., and Li, Y. (2022). Network Pharmacology of Iridoid Glycosides from Eucommia Ulmoides Oliver against Osteoporosis. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-10769-w"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.bone.2008.08.127","article-title":"Du-Zhong (Eucommia ulmoides Oliv.) Cortex Extract Prevent OVX-Induced Osteoporosis in Rats","volume":"45","author":"Zhang","year":"2009","journal-title":"Bone"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"117128","DOI":"10.1016\/j.jep.2023.117128","article-title":"Traditional Uses, Phytochemistry, Pharmacology, Applications, and Quality Control of Gastrodia Elata Blume: A Comprehensive Review","volume":"319","author":"Gong","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jep.2016.06.057","article-title":"The Rhizome of Gastrodia Elata Blume\u2014An Ethnopharmacological Review","volume":"189","author":"Zhan","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Li, Y., and Li, F. (2022). Mechanism and Prospect of Gastrodin in Osteoporosis, Bone Regeneration, and Osseointegration. Pharmaceuticals, 15.","DOI":"10.3390\/ph15111432"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"116957","DOI":"10.1016\/j.jep.2023.116957","article-title":"A Systematic Review of Traditional Uses, Phytochemistry, Pharmacology and Toxicity of Epimedium Koreanum Nakai","volume":"318","author":"Qian","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Cui, J., Lin, L., Hao, F., Shi, Z., Gao, Y., Yang, T., Yang, C., Wu, X., Gao, R., and Ru, Y. (2024). Comprehensive Review of the Traditional Uses and the Potential Benefits of Epimedium Folium. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1415265"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.pharmthera.2016.01.015","article-title":"Preclinical Studies and Clinical Evaluation of Compounds from the Genus Epimedium for Osteoporosis and Bone Health","volume":"162","author":"Indran","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Si, Y., Li, Y., Gu, K., Yin, H., Ma, Y., Si, Y., Li, Y., Gu, K., Yin, H., and Ma, Y. (2024). Icariin Ameliorates Osteoporosis in Ovariectomized Rats by Targeting Cullin 3\/Nrf2\/OH Pathway for Osteoclast Inhibition. Biomed. Pharmacother., 173.","DOI":"10.1016\/j.biopha.2024.116422"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00198-017-4255-1","article-title":"The Effect of Icariin on Bone Metabolism and Its Potential Clinical Application","volume":"29","author":"Wang","year":"2018","journal-title":"Osteoporos. Int."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"10123","DOI":"10.1002\/jcp.27678","article-title":"Icariin Protects against Iron Overload-induced Bone Loss via Suppressing Oxidative Stress","volume":"234","author":"Jing","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1002\/jcp.26405","article-title":"Iron Overload Induces G1 Phase Arrest and Autophagy in Murine Preosteoblast Cells","volume":"233","author":"Cen","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Yao, X., Jing, X., Guo, J., Sun, K., Deng, Y., Zhang, Y., Guo, F., and Ye, Y. (2019). Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K\/AKT\/mTOR and MAPK Pathways. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00163"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/jphp.13129","article-title":"Scutellaria Baicalensis Georgi. (Lamiaceae): A Review of Its Traditional Uses, Botany, Phytochemistry, Pharmacology and Toxicology","volume":"71","author":"Zhao","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"113198","DOI":"10.1016\/j.jep.2020.113198","article-title":"Traditional Uses, Ten-Years Research Progress on Phytochemistry and Pharmacology, and Clinical Studies of the Genus Scutellaria","volume":"265","author":"Shen","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Qin, W., Shang, Q., Shen, G., Li, B., Zhang, P., Zhang, Y., Zhao, W., Chen, H., Liu, H., and Xie, B. (2024). Restoring Bone-Fat Equilibrium: Baicalin\u2019s Impact on P38 MAPK Pathway for Treating Diabetic Osteoporosis. Biomed. Pharmacother., 175.","DOI":"10.1016\/j.biopha.2024.116571"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/09513590.2021.2015760","article-title":"Drynaria Fortunei Improves Lipid Profiles of Elderly Patients with Postmenopausal Osteoporosis via Regulation of Notch1-NLRP3 Inflammasome-Mediated Inflammation","volume":"38","author":"Lu","year":"2022","journal-title":"Gynecol. Endocrinol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"115565","DOI":"10.1016\/j.jep.2022.115565","article-title":"Gu Sui Bu (Drynaria fortunei J. Sm.) Antagonizes Glucocorticoid-Induced Mineralization Reduction in Zebrafish Larvae by Modulating the Activity of Osteoblasts and Osteoclasts","volume":"297","author":"Peng","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_144","first-page":"182","article-title":"Research Progress on Drynaria Fortunei Naringin on Inflammation and Bone Activity","volume":"28","author":"Yin","year":"2015","journal-title":"Zhongguo Gu Shang"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jep.2016.11.018","article-title":"Steroidogenic Effect of Erxian Decoction for Relieving Menopause via the P-Akt\/PKB Pathway in Vitro and in Vivo","volume":"195","author":"Wang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Wang, N., Xin, H., Xu, P., Yu, Z., Shou, D., Wang, N., Xin, H., Xu, P., Yu, Z., and Shou, D. (2019). Erxian Decoction Attenuates TNF-\u03b1 Induced Osteoblast Apoptosis by Modulating the Akt\/Nrf2\/HO-1 Signaling Pathway. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.00988"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wang, J., Huang, Y., Guo, L., Li, J., and Zhou, S. (2023). Molecular Mechanism of Achyranthis Bidentatae Radix and Morindae Officinalis Radix in Osteoporosis Therapy: An Investigation Based on Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations. Biochem. Biophys. Rep., 36.","DOI":"10.1016\/j.bbrep.2023.101586"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fitote.2017.01.009","article-title":"Metabolites of Curculigoside in Rats and Their Antiosteoporotic Activities in Osteoblastic MC3T3-E1 Cells","volume":"117","author":"Wang","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_149","first-page":"1","article-title":"Curculigoside Protects against Titanium Particle-Induced Osteolysis through the Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Formation","volume":"2021","author":"Zhu","year":"2021","journal-title":"J. Immunol. Res."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"117236","DOI":"10.1016\/j.jep.2023.117236","article-title":"Quality Evaluation of Angelica Sinensis Radix Dispensing Granules by Integrating Microvascular Activity and Chemical Analysis","volume":"319","author":"Li","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jep.2016.05.023","article-title":"Angelica Sinensis in China-A Review of Botanical Profile, Ethnopharmacology, Phytochemistry and Chemical Analysis","volume":"190","author":"Wei","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2147\/CIA.S117597","article-title":"Effects of Chinese Herbal Formula Erxian Decoction for Treating Osteoporosis: A Systematic Review","volume":"12","author":"Li","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"6641838","DOI":"10.1155\/2021\/6641838","article-title":"Analysis of Molecular Mechanism of Erxian Decoction in Treating Osteoporosis Based on Formula Optimization Model","volume":"2021","author":"Yang","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_154","first-page":"526","article-title":"Clinical Study of Bugu Shengsui Capsule in Treating Primary Osteoporosis with Kidney-Yang Deficiency Syndrome","volume":"17","author":"Xie","year":"1997","journal-title":"Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chin. J. Integr. Tradit. West. Med."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Huang, J., Cao, W., Yu, A., Li, P., Liang, J., Leng, X., Jin, J., Yu, P., and Liu, J. (2024). The Therapeutic Mechanism of Compound Lurong Jiangu Capsule for the Treatment of Cadmium-Induced Osteoporosis: Network Pharmacology and Experimental Verification. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1331488"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e15672","DOI":"10.1097\/MD.0000000000015672","article-title":"Efficacy of Xianling Gubao Capsule in Treating Sarco-Osteopenia","volume":"98","author":"Chen","year":"2019","journal-title":"Medicine"},{"key":"ref_157","first-page":"36","article-title":"Herbal Fufang Xian Ling Gu Bao Prevents Corticosteroid-Induced Osteonecrosis of the Femoral Head\u2014A First Multicentre, Randomised, Double-Blind, Placebo-Controlled Clinical Trial","volume":"12","author":"Li","year":"2018","journal-title":"J. Orthop. Transl."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"115292","DOI":"10.1016\/j.jep.2022.115292","article-title":"Bioinformatics Analysis Combined with Experimental Validation to Explore the Mechanism of XianLing GuBao Capsule against Osteoarthritis","volume":"294","author":"Xiao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2532081","DOI":"10.1155\/2020\/2532081","article-title":"Effect of Qing\u2019e Decoction on Leptin\/Leptin Receptor and Bone Metabolism in Naturally Aging Rats","volume":"2020","author":"Sun","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"114735","DOI":"10.1016\/j.jep.2021.114735","article-title":"Elucidating the Estrogen-like Effects and Biocompatibility of the Herbal Components in the Qing\u2019 E Formula","volume":"283","author":"Xiong","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jep.2016.05.025","article-title":"Traditional Chinese Medicine Formulas for the Treatment of Osteoporosis: Implication for Antiosteoporotic Drug Discovery","volume":"189","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"155257","DOI":"10.1016\/j.phymed.2023.155257","article-title":"Zuogui Pill Disrupt the Malignant Cycle in Breast Cancer Bone Metastasis through the Piezo1-Notch-1-GPX4 Pathway and Active Molecules Fishing","volume":"123","author":"Li","year":"2024","journal-title":"Phytomedicine"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/4\/367\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:08:39Z","timestamp":1760029719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/4\/367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":162,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["biology14040367"],"URL":"https:\/\/doi.org\/10.3390\/biology14040367","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]}}}