{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:26:25Z","timestamp":1791491185426,"version":"4.3.4"},"reference-count":66,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T00:00:00Z","timestamp":1743811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fondo de Apoyo a la Investigaci\u00f3n","award":["C19-FAI-05-86.86"],"award-info":[{"award-number":["C19-FAI-05-86.86"]}]},{"name":"Fondo de Apoyo a la Investigaci\u00f3n","award":["511-6\/2019.-8024"],"award-info":[{"award-number":["511-6\/2019.-8024"]}]},{"name":"Fondo de Apoyo a la Investigaci\u00f3n","award":["511-6\/2019.-12305"],"award-info":[{"award-number":["511-6\/2019.-12305"]}]},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed","award":["C19-FAI-05-86.86"],"award-info":[{"award-number":["C19-FAI-05-86.86"]}]},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed","award":["511-6\/2019.-8024"],"award-info":[{"award-number":["511-6\/2019.-8024"]}]},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed","award":["511-6\/2019.-12305"],"award-info":[{"award-number":["511-6\/2019.-12305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Kalanchoe daigremontiana, a medicinal plant rich in bioactive compounds, has the potential to serve as a feed supplement, reducing reliance on conventional livestock medications while potentially enhancing productivity. This study evaluated the effects of K. daigremontiana supplementation over 52 days on kidney and liver function, metabolism, weight changes, and reproductive efficiency in multiparous Alpine goats during the breeding season. Fifty-five goats were assigned to either a control (CTL, n = 27; 47.6 \u00b1 1.1 kg) or a K. daigremontiana-supplemented (KAL, n = 28; 47.6 \u00b1 1.3 kg) diet. The KAL group received K. daigremontiana at a dry matter-based inclusion rate of 2 kg t\u22121 of feed, while the CTL group received no supplementation. Blood samples were collected at four time points to assess the biochemical markers of kidney and liver function. Pregnancy was achieved through natural mating, and reproductive efficiency was evaluated. Overall, liver and kidney function did not differ significantly between treatments (p &gt; 0.05). However, KAL supplementation was associated with increased creatinine (p &lt; 0.05), ALP (p &lt; 0.001), and bilirubin (p &lt; 0.05) at specific time points, whereas CTL goats exhibited higher BUN (p &lt; 0.001), AST (p &lt; 0.05), albumin (p &lt; 0.001), total protein (p \u2264 0.05), and phosphorus (p &lt; 0.01) on specific dates. Other metabolic markers, weight gain, and reproductive efficiency did not differ between treatments (p &gt; 0.05). Overall, Kalanchoe daigremontiana supplementation had mild, transient effects on goat health without significantly impacting productivity. Further research is needed to explore its long-term effects and optimal dosage for livestock nutrition.<\/jats:p>","DOI":"10.3390\/biology14040376","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T11:24:39Z","timestamp":1744025079000},"page":"376","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Kalanchoe (Kalanchoe daigremontiana) Supplementation in Goat Maternal Diet on Hepatic and Renal Function and Reproductive Performance"],"prefix":"10.3390","volume":"14","author":[{"given":"Juan M.","family":"V\u00e1zquez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Facultad de Agronom\u00eda y Veterinaria, Universidad Aut\u00f3noma San Luis Potos\u00ed, San Luis Potos\u00ed 78321, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Ballesteros-Rodea","sequence":"additional","affiliation":[{"name":"Facultad de Agronom\u00eda y Veterinaria, Universidad Aut\u00f3noma San Luis Potos\u00ed, San Luis Potos\u00ed 78321, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9946-3942","authenticated-orcid":false,"given":"Venancio","family":"Cuevas-Reyes","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investigaciones Forestales, Agr\u00edcolas y Pecuarias, Campo Experimental Valle de M\u00e9xico, Texcoco 56250, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa E. S.","family":"Hern\u00e1ndez-Arteaga","sequence":"additional","affiliation":[{"name":"Facultad de Agronom\u00eda y Veterinaria, Universidad Aut\u00f3noma San Luis Potos\u00ed, San Luis Potos\u00ed 78321, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Y.","family":"Pe\u00f1a-Avelino","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia, Universidad Aut\u00f3noma de Tamaulipas, Ciudad Victoria 87000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0465-5365","authenticated-orcid":false,"given":"Samuel","family":"L\u00f3pez-Aguirre","sequence":"additional","affiliation":[{"name":"Facultad de Medicina Veterinaria y Zootecnia, Universidad Veracruzana, Veracruz 91710, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reagan","family":"Sims","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, Texas State University, San Marcos, TX 78666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3437-2029","authenticated-orcid":false,"given":"Jaime M.","family":"Cavazos-Galindo","sequence":"additional","affiliation":[{"name":"Centro de Fomento Ganadero Vallecillo, Universidad Aut\u00f3noma de Nuevo Le\u00f3n, San Nicol\u00e1s de los Garza 65415, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-338X","authenticated-orcid":false,"given":"Cesar A.","family":"Rosales-Nieto","sequence":"additional","affiliation":[{"name":"Facultad de Agronom\u00eda y Veterinaria, Universidad Aut\u00f3noma San Luis Potos\u00ed, San Luis Potos\u00ed 78321, Mexico"},{"name":"Department of Agricultural Sciences, Texas State University, San Marcos, TX 78666, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,5]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Use of Fresh Parts of Medicinal Plants for Health and Production in Livestock\u2014A New Concept of Farming","volume":"3","author":"Pattanayak","year":"2013","journal-title":"Explor. 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