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To elucidate this further, this study investigated the electron-shuttling bioactive compounds of OT and evaluated their effect on dysregulated breast cancer (BC) genes. OT extracts were obtained via solvent extraction (SE) and supercritical fluid extraction (SFE), followed by in vitro assays. Phytochemical analysis revealed that ethanol-extracted OT (OTL-E) had the highest polyphenol, flavonoid, and tannin contents, correlating with strong antioxidant activity, while water-extracted OT (OTL-W) exhibited greater bioelectricity-stimulating properties in microbial fuel cells (MFC), confirmed by cyclic voltammetry (CV). Based on phytochemical analyses, SE displayed a better extraction technique for isolating OT bioactive compounds compared to SFE. In silico approaches through network pharmacology, molecular docking and dynamics simulations revealed that polyphenols with ortho- or para-dihydroxyl groups targeted dysregulated BC proteins involved in kinase signaling, apoptosis, and hormone receptor pathways. Luteolin exhibited the highest binding affinities to MAPK1 and PIK3CA with free energy (\u0394G) of \u22129.1 and \u22128.4 kcal\/mol, respectively. Trajectory-based analyses confirmed enthalpy-favored ligand-induced conformational changes to these oncoproteins, altering their function in BC development. These findings suggest the potential of OT as a bioelectricity-stimulating and chemopreventive agent, warranting further in vitro and in vivo validation.<\/jats:p>","DOI":"10.3390\/biology14050487","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T09:00:39Z","timestamp":1745917239000},"page":"487","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deciphering the Regulatory Potential of Antioxidant and Electron-Shuttling Bioactive Compounds in Oolong Tea"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1105-9322","authenticated-orcid":false,"given":"Regineil A.","family":"Ferrer","sequence":"first","affiliation":[{"name":"School of Chemical, Biological, and Materials Engineering and Sciences, Map\u00faa University, Manila 1002, Philippines"},{"name":"School of Graduate Studies, Map\u00faa University, Manila 1002, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4449-2759","authenticated-orcid":false,"given":"Bor-Yann","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, National I-lan University, I-lan 260, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5081-9263","authenticated-orcid":false,"given":"Jon Patrick T.","family":"Garcia","sequence":"additional","affiliation":[{"name":"School of Chemical, Biological, and Materials Engineering and Sciences, Map\u00faa University, Manila 1002, Philippines"},{"name":"School of Graduate Studies, Map\u00faa University, Manila 1002, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1266-1783","authenticated-orcid":false,"given":"Christine Joyce F.","family":"Rejano","sequence":"additional","affiliation":[{"name":"School of Chemical, Biological, and Materials Engineering and Sciences, Map\u00faa University, Manila 1002, Philippines"},{"name":"School of Graduate Studies, Map\u00faa University, Manila 1002, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1981-5360","authenticated-orcid":false,"given":"Po-Wei","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Food Science, National Taiwan Ocean University, Keelung 202, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung-Chuan","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Chemical and Materials Engineering, National I-lan University, I-lan 260, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lemmuel L.","family":"Tayo","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Health Sciences, Map\u00faa University, Makati 1200, Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, C., Han, J., Pu, Y., and Wang, X. 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