{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:33:04Z","timestamp":1760059984701,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Natural Science Foundation Grants","award":["7242014","BMR2021-3","DFL20221102","XZYB-04"],"award-info":[{"award-number":["7242014","BMR2021-3","DFL20221102","XZYB-04"]}]},{"name":"Public service development and reform pilot project of Beijing Medical Research Institute","award":["7242014","BMR2021-3","DFL20221102","XZYB-04"],"award-info":[{"award-number":["7242014","BMR2021-3","DFL20221102","XZYB-04"]}]},{"name":"Beijing Hospitals Authority\u2019s Ascent Plan","award":["7242014","BMR2021-3","DFL20221102","XZYB-04"],"award-info":[{"award-number":["7242014","BMR2021-3","DFL20221102","XZYB-04"]}]},{"name":"New Quality Foundation of Capital Institute of Pediatrics","award":["7242014","BMR2021-3","DFL20221102","XZYB-04"],"award-info":[{"award-number":["7242014","BMR2021-3","DFL20221102","XZYB-04"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The interaction between epigenetic mechanisms and the gut microbiome is potentially crucial for the development and maintenance of intestinal health. Lysine acetylation, an important post-translational modification, plays a complex and critical role in the epigenetic regulation of the host by the gut microbiota. However, there are currently no reports on how gut microbiota dysbiosis affects host physiology in early life through global lysine acetylation. In this study, we constructed a mouse model of gut microbiota dysbiosis using antibiotic cocktail therapy (ABX). Using liquid chromatography-tandem mass spectrometry (LC-MS\/MS) in the cecum, we analyzed the cecal lysine acetylome and proteome. As a result, we profiled the lysine acetylation landscape of the cecum and identified a total of 16,579 acetylation sites from 5218 proteins. Differentially acetylated proteins (DAPs) are involved in various metabolic pathways, including the citrate cycle (TCA cycle), butanoate metabolism, pyruvate metabolism, glycolysis\/gluconeogenesis, and fatty acid biosynthesis. Moreover, both glycolysis and gluconeogenesis are significantly enriched in acetylation and protein modifications. This study aimed to provide valuable insights into the epigenetic molecular mechanisms associated with host protein acetylation as influenced by early-life gut microbiota disturbances. It reveals potential therapeutic targets for metabolic disorders linked to gut microbiota dysbiosis, thereby establishing a theoretical foundation for the clinical prevention and treatment of diseases arising from such dysbiosis.<\/jats:p>","DOI":"10.3390\/biology14080917","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T11:52:47Z","timestamp":1753271567000},"page":"917","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut Microbiota Dysbiosis Remodels the Lysine Acetylome of the Mouse Cecum in Early Life"],"prefix":"10.3390","volume":"14","author":[{"given":"Yubing","family":"Zeng","sequence":"first","affiliation":[{"name":"Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinying","family":"Shen","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"},{"name":"Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejia","family":"He","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"},{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2273-2491","authenticated-orcid":false,"given":"Fan","family":"Liu","sequence":"additional","affiliation":[{"name":"Child Healthcare Center, Capital Center for Children\u2019s Health, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children\u2019s Hospital, Capital Medical University, National Center for Children\u2019s Health, Beijing 100045, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Pei","sequence":"additional","affiliation":[{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China"},{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing 100020, China"},{"name":"Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Peking University Teaching Hospital, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/s41579-025-01163-0","article-title":"Microbiota in inflammatory bowel disease: Mechanisms of disease and therapeutic opportunities","volume":"23","author":"Iliev","year":"2025","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.tim.2024.05.006","article-title":"Unraveling host regulation of gut microbiota through the epigenome-microbiome axis","volume":"32","author":"Pepke","year":"2024","journal-title":"Trends Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev-animal-022114-111112","article-title":"The impact of the milk glycobiome on the neonate gut microbiota","volume":"3","author":"Pacheco","year":"2015","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature11053","article-title":"Human gut microbiome viewed across age and geography","volume":"486","author":"Yatsunenko","year":"2012","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.tips.2024.07.006","article-title":"Emerging chemophysiological diversity of gut microbiota metabolites","volume":"45","author":"Lin","year":"2024","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41579-020-0438-4","article-title":"Gut microbial metabolites as multi-kingdom intermediates","volume":"19","author":"Krautkramer","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/19490976.2019.1638722","article-title":"Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health","volume":"11","author":"Parker","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2508426","DOI":"10.1080\/19490976.2025.2508426","article-title":"Implications of gut microbiota-mediated epigenetic modifications in intestinal diseases","volume":"17","author":"Zhang","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e2307981","DOI":"10.1002\/advs.202307981","article-title":"Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41577-024-01014-8","article-title":"Short-chain fatty acids: Linking diet, the microbiome and immunity","volume":"24","author":"Mann","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/19490976.2015.1134082","article-title":"Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism","volume":"7","author":"Morrison","year":"2016","journal-title":"Gut Microbes"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2022407","DOI":"10.1080\/19490976.2021.2022407","article-title":"Epigenetic regulation by gut microbiota","volume":"14","author":"Woo","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrg.2016.138","article-title":"From profiles to function in epigenomics","volume":"18","author":"Stricker","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s42255-024-00992-2","article-title":"Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression","volume":"6","author":"Gates","year":"2024","journal-title":"Nat. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41564-019-0659-3","article-title":"The microbiota programs DNA methylation to control intestinal homeostasis and inflammation","volume":"5","author":"Ansari","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-017-02651-5","article-title":"Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases","volume":"9","author":"Fellows","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhang, W., Sun, J., Cao, H., Tian, R., Cai, L., Ding, W., and Qian, P.Y. (2016). Post-translational modifications are enriched within protein functional groups important to bacterial adaptation within a deep-sea hydrothermal vent environment. Microbiome, 4.","DOI":"10.1186\/s40168-016-0194-x"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jprot.2016.08.001","article-title":"Systematic analysis of the lysine acetylome of the pathogenic bacterium Spiroplasma eriocheiris reveals acetylated proteins related to metabolism and helical structure","volume":"148","author":"Meng","year":"2016","journal-title":"J. Proteom."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e02708-18","DOI":"10.1128\/mBio.02708-18","article-title":"Mechanisms, Detection, and Relevance of Protein Acetylation in Prokaryotes","volume":"10","author":"Christensen","year":"2019","journal-title":"mBio"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111809","DOI":"10.1016\/j.celrep.2022.111809","article-title":"Stable isotope tracing in vivo reveals a metabolic bridge linking the microbiota to host histone acetylation","volume":"41","author":"Lund","year":"2022","journal-title":"Cell Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6594","DOI":"10.1021\/acs.analchem.1c00962","article-title":"Exploring the Microbiome-Wide Lysine Acetylation, Succinylation, and Propionylation in Human Gut Microbiota","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zou, D., Pei, J., Lan, J., Sang, H., Chen, H., Yuan, H., Wu, D., Zhang, Y., Wang, Y., and Wang, D. (2020). A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. eBioMedicine, 52.","DOI":"10.1016\/j.ebiom.2020.102652"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Liu, F., Yan, W., Chen, C., Zeng, Y., Kong, Y., He, X., Pei, P., Wang, S., and Zhang, T. (2024). Acetylome analyses provide novel insights into the effects of chronic intermittent hypoxia on hippocampus-dependent cognitive impairment. Front. Mol. Neurosci., 17.","DOI":"10.3389\/fnmol.2024.1324458"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/EBC20230080","article-title":"Acetylation, ADP-ribosylation and methylation of malate dehydrogenase","volume":"68","author":"Kuhn","year":"2024","journal-title":"Essays Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109678","DOI":"10.1016\/j.isci.2024.109678","article-title":"The acetylation of MDH1 and IDH1 is associated with energy metabolism in acute liver failure","volume":"27","author":"Shi","year":"2024","journal-title":"iScience"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"168303","DOI":"10.1016\/j.scitotenv.2023.168303","article-title":"Protein lysine acetylation played an important role in NH(3)-induced AEC2 damage and pulmonary fibrosis in piglets","volume":"908","author":"Wang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Su, G., Xu, Y., Chen, B., Ju, K., Jin, Y., Chen, H., Zhang, S., and Luan, X. (2025). Structural and biochemical mechanism of short-chain enoyl-CoA hydratase (ECHS1) substrate recognition. Commun. Biol., 8.","DOI":"10.1038\/s42003-025-07924-0"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1038\/s41467-022-35199-0","article-title":"Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation","volume":"13","author":"Li","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications\u2014Cause and consequence of genome function","volume":"23","author":"Burton","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"D\u2019Aquila, P., Carelli, L.L., De Rango, F., Passarino, G., and Bellizzi, D. (2020). Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients, 12.","DOI":"10.3390\/nu12030597"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2393270","DOI":"10.1080\/19490976.2024.2393270","article-title":"The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease","volume":"16","author":"Hays","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s42255-024-01191-9","article-title":"Short-chain fatty acid metabolites propionate and butyrate are unique epigenetic regulatory elements linking diet, metabolism and gene expression","volume":"7","author":"Nshanian","year":"2025","journal-title":"Nat. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101798","DOI":"10.1016\/j.xcrm.2024.101798","article-title":"Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation","volume":"5","author":"Qian","year":"2024","journal-title":"Cell Rep. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cmet.2023.04.015","article-title":"Lactobacillus plantarum-derived indole-3-lactic acid ameliorates colorectal tumorigenesis via epigenetic regulation of CD8(+) T cell immunity","volume":"35","author":"Zhang","year":"2023","journal-title":"Cell Metab."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.immuni.2024.01.002","article-title":"Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity","volume":"57","author":"Eshleman","year":"2024","journal-title":"Immunity"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2117509","DOI":"10.1080\/19490976.2022.2117509","article-title":"Gut microbiota mediates the inhibition of lymphopoiesis in dietary-restricted mice by suppressing glycolysis","volume":"14","author":"Tao","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Hu, J., Chen, J., Hou, Q., Xu, X., Ren, J., Ma, L., and Yan, X. (2023). Core-predominant gut fungus Kazachstania slooffiae promotes intestinal epithelial glycolysis via lysine desuccinylation in pigs. Microbiome, 11.","DOI":"10.1186\/s40168-023-01468-3"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106530","DOI":"10.1016\/j.phrs.2022.106530","article-title":"The role of microbiota-mitochondria crosstalk in pathogenesis and therapy of intestinal diseases","volume":"186","author":"Zhang","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.chom.2022.01.001","article-title":"3\u03b2-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males","volume":"30","author":"Li","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"T37","DOI":"10.1530\/JME-22-0082","article-title":"Retinoid metabolism: New insights","volume":"69","author":"Gudas","year":"2022","journal-title":"J. Mol. Endocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cmet.2022.04.001","article-title":"Microbiota alterations in proline metabolism impact depression","volume":"34","author":"Martin","year":"2022","journal-title":"Cell Metab."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41388-022-02528-y","article-title":"TNF\u03b1-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity","volume":"42","author":"Yang","year":"2023","journal-title":"Oncogene"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s42255-020-00325-z","article-title":"Mitochondrial long non-coding RNA GAS5 tunes TCA metabolism in response to nutrient stress","volume":"3","author":"Sang","year":"2021","journal-title":"Nat. Metab."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.15252\/embj.201591041","article-title":"SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth","volume":"34","author":"Yang","year":"2015","journal-title":"Embo J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1179689","article-title":"Regulation of cellular metabolism by protein lysine acetylation","volume":"327","author":"Zhao","year":"2010","journal-title":"Science"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"177710","DOI":"10.1016\/j.ejphar.2025.177710","article-title":"Therapeutic potential of butyrate against heat Stress-Induced intestinal damage, systemic inflammation, and multiple organ Dysfunction: Insights from in vitro and in vivo experiments","volume":"999","author":"Ke","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1136\/gutjnl-2022-327337","article-title":"Rewiring the altered tryptophan metabolism as a novel therapeutic strategy in inflammatory bowel diseases","volume":"72","author":"Michaudel","year":"2023","journal-title":"Gut"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.trecan.2024.11.003","article-title":"Short-chain fatty acids and cancer","volume":"11","author":"Li","year":"2025","journal-title":"Trends Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.cell.2016.05.018","article-title":"The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites","volume":"165","author":"Kaiko","year":"2016","journal-title":"Cell"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/s13046-025-03399-3","article-title":"Acetylation-induced degradation of ECHS1 enhances BCAA accumulation and proliferation in KRAS-mutant colorectal cancer","volume":"44","author":"Li","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41467-022-28044-x","article-title":"The mitochondrial \u03b2-oxidation enzyme HADHA restrains hepatic glucagon response by promoting \u03b2-hydroxybutyrate production","volume":"13","author":"Pan","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12380","DOI":"10.1074\/jbc.RA119.008680","article-title":"Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex","volume":"294","author":"Wang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.molcel.2020.08.015","article-title":"Histone Deacetylase 3 Couples Mitochondria to Drive IL-1\u03b2-Dependent Inflammation by Configuring Fatty Acid Oxidation","volume":"80","author":"Chi","year":"2020","journal-title":"Mol. Cell."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1111\/nph.18294","article-title":"The Fng3 ING protein regulates H3 acetylation and H4 deacetylation by interacting with two distinct histone-modifying complexes","volume":"235","author":"Xu","year":"2022","journal-title":"N. Phytol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lai, K.K.Y., Hu, X., Chosa, K., Nguyen, C., Lin, D.P., Lai, K.K., Kato, N., Higuchi, Y., Highlander, S.K., and Melendez, E. (2021). p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair. Cancers, 13.","DOI":"10.3390\/cancers13061288"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/s43587-022-00308-7","article-title":"Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin","volume":"2","author":"Regan","year":"2022","journal-title":"Nat. Aging"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2295429","DOI":"10.1080\/19490976.2023.2295429","article-title":"Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction","volume":"16","author":"Cross","year":"2024","journal-title":"Gut Microbes"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1007\/s00248-023-02188-9","article-title":"Distinguishable Influence of the Delivery Mode, Feeding Pattern, and Infant Sex on Dynamic Alterations in the Intestinal Microbiota in the First Year of Life","volume":"86","author":"Ma","year":"2023","journal-title":"Microb. Ecol."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/8\/917\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:14:22Z","timestamp":1760033662000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/8\/917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":59,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["biology14080917"],"URL":"https:\/\/doi.org\/10.3390\/biology14080917","relation":{},"ISSN":["2079-7737"],"issn-type":[{"type":"electronic","value":"2079-7737"}],"subject":[],"published":{"date-parts":[[2025,7,23]]}}}