{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T08:02:38Z","timestamp":1769932958759,"version":"3.49.0"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Academy of Romanian Scientists\u2019 Research Project Competition for Young Researchers \u201cAOSR-TEAMS-II\u201d EDITION 2023\u20132024\u2014\u201cDigital Transformation in Science\u201d","award":["28\/11.04.2023"],"award-info":[{"award-number":["28\/11.04.2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Modern life, characterized by constant exposure to artificial light from electronic devices, such as light-emitting diodes (LEDs), disrupts the natural circadian rhythm and induces important metabolic changes. The impact of blue light exposure on male and female rat\u2019s onset of puberty, hormonal and biochemical parameters was assessed by comparison between the four study groups: the control group (CTRL) maintained under normal light conditions, the group exposed to blue light from a mobile phone (MP), the group subjected to blue light from a computer screen (PC), and the group exposed to blue light from an LED lamp (LED). Both female and male rats exposed to PC and LED failed to thrive, with a significantly lower body weight intake than the CTRL group. All three distinct sources of blue light interfered with the cyclicity of the estrous cycle in female rats. A marked decrease in the number of complete estrous cycles and the highest incidence of incomplete cycles were noticed in the LED group. Elevated ALT, AST, glucose, and insulin levels were influenced in a gender-specific manner, and depending on the source of emitted light. Prolonged blue light exposure induces significant metabolic disruptions and possesses important future research potential in identifying explicit pathways regarding this environmental stressor.<\/jats:p>","DOI":"10.3390\/biology14080951","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:50:03Z","timestamp":1753714203000},"page":"951","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Blue Light Effect on Metabolic Changes in Induced Precocious Puberty in Rats"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-1011","authenticated-orcid":false,"given":"Luciana-M\u0103d\u0103lina","family":"Gherman","sequence":"first","affiliation":[{"name":"Experimental Centre, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Louis Pasteur, No. 6, 400349 Cluj-Napoca, Romania"},{"name":"Academy of Romanian Scientists, Ilfov 3, 050044 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena-Mihaela","family":"Jianu","sequence":"additional","affiliation":[{"name":"Histology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No. 8, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0570-0642","authenticated-orcid":false,"given":"\u0218tefan Horia","family":"Ro\u0219ian","sequence":"additional","affiliation":[{"name":"\u201cNiculae St\u0103ncioiu\u201d Heart Institute Cluj-Napoca, 19-21 Calea Mo\u021bilor Street, 400001 Cluj-Napoca, Romania"},{"name":"Department of Cardiology\u2014Heart Institute, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, Calea Mo\u021bilor Street No. 19-21, 400001 Cluj-Napoca, 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Romania"},{"name":"Pathophysiology, Department of Morphofunctional Sciences, Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen Mihaela","family":"Mihu","sequence":"additional","affiliation":[{"name":"Histology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No. 8, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4419-7143","authenticated-orcid":false,"given":"C\u0103t\u0103lina Angela","family":"Cri\u015fan","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, \u201cIuliu Ha\u0163ieganu\u201d University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0218tefan 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