{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:37:45Z","timestamp":1792791465278,"version":"4.5.0"},"reference-count":94,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Reproductive Medicine Bocian"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Endometriosis significantly impacts fertility through complex mechanisms. These include chronic inflammation, oxidative stress, and anatomical distortion. These mechanisms impair oocyte quality, embryo development, and implantation. While in vivo challenges persist, in vitro fertilization (IVF) offers a controlled environment to overcome some barriers. A systematic review of evidence is presented for (1) endometriosis-associated oocyte dysfunction, (2) conflicting IVF outcomes, and (3) innovative strategies. Significant medical advancements have been made. However, gaps remain in personalized prognosis and targeted therapies. Emerging tools, specifically AI-driven embryo selection, single-cell omics, and immunomodulation, are promising for improving outcomes. Hence, a patient-centered approach, balancing science with personalized care, is essential to navigate endometriosis-related infertility.<\/jats:p>","DOI":"10.3390\/biology14080957","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T07:37:23Z","timestamp":1753861043000},"page":"957","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vivo Shadows and In Vitro Light: The Early Embryological Journey Amid Endometriosis"],"prefix":"10.3390","volume":"14","author":[{"given":"Grzegorz","family":"Mrugacz","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine Bocian, Bia\u0142ystok Branch, 26 Akademicka St., 15-267 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mospinek","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Bocian, \u0141\u00f3d\u017a Branch, 157a Piotrkowska St., 90-440 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Modrzy\u0144ska-Olejniczak","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Bocian, \u0141\u00f3d\u017a Branch, 157a Piotrkowska St., 90-440 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"Byczkowski","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Bocian, \u0141\u00f3d\u017a Branch, 157a Piotrkowska St., 90-440 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Radaj","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Bocian, Lublin Branch, 26 Relaksowa St., 20-819 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0552-2855","authenticated-orcid":false,"given":"Piotr","family":"Olcha","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine Bocian, Lublin Branch, 26 Relaksowa St., 20-819 Lublin, Poland"},{"name":"Department of Gynecology and Gynecological Endocrinology, Medical University of Lublin, Al. 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