{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:19:33Z","timestamp":1790205573609,"version":"4.1.0"},"reference-count":151,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004561","name":"Committee of Science of the Ministry of Education and Science of the Republic of Kazakhstan","doi-asserted-by":"publisher","award":["AP13068269"],"award-info":[{"award-number":["AP13068269"]}],"id":[{"id":"10.13039\/501100004561","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Mesenchymal stem cells (MSCs) are a type of multipotent, non-hematopoietic cells of mesodermal origin. Due to their strong immunomodulatory, immunosuppressive, and regenerative potential, MSCs are used in cell therapy for inflammatory, immune-mediated, and degenerative diseases. Exosomes derived from MSCs have several advantages over MSC therapy, including non-immunogenicity, lack of infusion toxicity, ease of isolation, manipulation, and storage, cargo specificity, and the absence of tumor-forming potential and ethical concerns. We hypothesized that preconditioning human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) with the proinflammatory cytokines interleukin 17 (IL-17), IL-22, and tumor necrosis factor alpha (TNF-\u03b1), the increased levels of which are typical in psoriasis patients, can significantly increase the therapeutic efficacy of both hUCB-MSCs and their exosomes (hUCB-MSC-Exo). Our aim was to compare the therapeutic effects of hUCB-MSCs preconditioned with various combinations of proinflammatory cytokines and their hUCB-MSC-Exo, in an in vivo imiquimod-induced psoriasis-like skin inflammation model in mice. Our results showed a significant attenuation of psoriasis symptoms (erythema, scaling, and skin thickness) in mice treated with intact hUCB-MSCs, hUCB-MSCs preconditioned with IL-22 and TNF-\u03b1, and hUCB-MSC-Exo preconditioned with IL-17, IL-22 and TNF-\u03b1 (MSC-Exo 3C). However, the most pronounced therapeutic effect was observed with MSC-Exo 3C treatment. In summary, we demonstrated that MSC-Exo 3C transplantation has therapeutic potential for treating psoriasis-like skin lesions.<\/jats:p>","DOI":"10.3390\/biology14081033","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T14:32:36Z","timestamp":1754922756000},"page":"1033","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Study of the Therapeutic Effect of Cytokine-Preconditioned Mesenchymal Stem Cells and Their Exosomes in a Mouse Model of Psoriasis"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1529-8471","authenticated-orcid":false,"given":"Aidar","family":"Dairov","sequence":"first","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"},{"name":"Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-2510","authenticated-orcid":false,"given":"Assel","family":"Issabekova","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madina","family":"Sarsenova","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-1731","authenticated-orcid":false,"given":"Aliya","family":"Sekenova","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7486-5267","authenticated-orcid":false,"given":"Miras","family":"Shakhatbayev","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Symbat","family":"Alimbek","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-4099","authenticated-orcid":false,"given":"Gulshakhar","family":"Kudaibergen","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assiya","family":"Nurkina","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Akhmetollayev","sequence":"additional","affiliation":[{"name":"Laboratory for Development of Molecular Diagnostic Approaches, National Center for Biotechnology, Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Sun","family":"Kang","sequence":"additional","affiliation":[{"name":"Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-5255","authenticated-orcid":false,"given":"Vyacheslav","family":"Ogay","sequence":"additional","affiliation":[{"name":"Stem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan"},{"name":"Department of General Biology and Genomics, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jaad.2008.02.039","article-title":"Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 1. Overview of psoriasis and guidelines of care for the treatment of psoriasis with biologics","volume":"58","author":"Menter","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/annrheumdis-2018-214065","article-title":"Prevalence and incidence of psoriasis and psoriatic arthritis","volume":"78","author":"Sewerin","year":"2019","journal-title":"Ann. Rheum. 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