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University","award":["CX2024084"],"award-info":[{"award-number":["CX2024084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Ferroptosis, a distinct form of programmed cell death characterized by iron-dependent lipid peroxidation, has emerged as a critical factor in the pathogenesis of various diseases. Given the increasing prevalence of osteoporosis worldwide and the increasing incidence of osteoporosis, understanding the molecular mechanisms underlying bone loss is imperative for developing targeted therapies. Recent evidence suggests that ferroptosis plays a pivotal role in osteoporosis by influencing the balance between osteoblast and osteoclast activity. This review examines the mechanistic basis of ferroptosis and its pathological implications in osteoporosis. By delineating the interplay between ferroptosis and skeletal remodeling, we highlight potential therapeutic strategies aimed at modulating ferroptosis to mitigate osteoporosis progression.<\/jats:p>","DOI":"10.3390\/biology14081062","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T16:09:55Z","timestamp":1755274195000},"page":"1062","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Targeting Ferroptosis: Emerging Insights into Osteoporosis Mechanisms"],"prefix":"10.3390","volume":"14","author":[{"given":"Hailing","family":"Yang","sequence":"first","affiliation":[{"name":"Laboratory for Bone Metabolism, Xi\u2019an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Ru","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism, Xi\u2019an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Xijing Hospital, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism, Xi\u2019an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0740-9218","authenticated-orcid":false,"given":"Airong","family":"Qian","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism, Xi\u2019an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-1409","authenticated-orcid":false,"given":"Zhihao","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory for Bone Metabolism, Xi\u2019an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, School of Life Sciences, Northwestern Polytechnical University, Xi\u2019an 710129, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jot.2020.09.006","article-title":"Chondrocyte Ferroptosis Contribute to the Progression of Osteoarthritis","volume":"27","author":"Yao","year":"2021","journal-title":"J. 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