{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:48:23Z","timestamp":1793641703892,"version":"4.5.1"},"reference-count":67,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The human sphenoid bone (SB), centrally located at the cranial base, is structurally and developmentally complex. It arises from multiple cartilaginous precursors and undergoes both endochondral and intramembranous ossification, forming essential elements such as the sella, orbital walls, and numerous foramina. This review integrates embryological, anatomical, and radiological findings to present a comprehensive view of SB development and variation. Embryological studies reveal a layered ossification sequence, with accessory centers in the presphenoid and basisphenoid that influence adult morphology and variants, such as the caroticoclinoid foramen. In adulthood, the SB consists of a central body, paired greater and lesser wings, and the pterygoid processes, which articulate with key craniofacial bones and transmit vital neurovascular structures. Notable variants include duplication or absence of foramina, ossification of ligaments such as the pterygoid and pterygospinous ligaments, and the formation of bony bridges among the clinoid processes. These variants may affect cranial nerve trajectories and surgical access, posing potential risks during neurosurgical, endoscopic, and dental interventions. Emissary structures such as the sphenoidal emissary foramen and the newly described sphenopterygoid canal underscore the region\u2019s vascular complexity. Additionally, variations in the optic and Vidian canals, as well as the superior orbital fissure, can also impact surgical approaches to the orbit, sinuses, and skull base. Understanding the full spectrum of sphenoid bone embryogenesis and morphology is essential for safe clinical practice and practical radiological imaging.<\/jats:p>","DOI":"10.3390\/biology14081090","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T13:18:14Z","timestamp":1755695894000},"page":"1090","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Developing Human Sphenoid Bone: Linking Embryological Development to Adult Morphology"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0122-2436","authenticated-orcid":false,"given":"George","family":"Triantafyllou","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"\u201cVARIANTIS\u201d Research Laboratory, Department of Clinical Anatomy, Masovian Academy in P\u0142ock, 09400 P\u0142ock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-8005","authenticated-orcid":false,"given":"Maria","family":"Piagkou","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Faculty of Health Sciences, National and Kapodistrian University of Athens, 11527 Athens, Greece"},{"name":"\u201cVARIANTIS\u201d Research Laboratory, Department of Clinical Anatomy, Masovian Academy in P\u0142ock, 09400 P\u0142ock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"152236","DOI":"10.1016\/j.aanat.2024.152236","article-title":"Cochlear Aqueduct Revisited: A Histological Study Using Human Fetuses","volume":"253","author":"Cho","year":"2024","journal-title":"Ann. Anat. Anat. Anz."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/ar.25355","article-title":"Topohistology of the Cranial Nerves IX\u2013XII at the Cranial Base and Upper Parapharyngeal Space: A Histological Study Using Human Fetuses","volume":"308","author":"Cho","year":"2025","journal-title":"Anat. Rec."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1002\/ar.25507","article-title":"Transient Contribution of the Sphenoid Ala Major to the Socket of the Temporomandibular Joint in Near-term Fetuses","volume":"307","author":"Hirouchi","year":"2024","journal-title":"Anat. Rec."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"152389","DOI":"10.1016\/j.aanat.2025.152389","article-title":"Origin, Communication and Course of the Vagus Nerve Auricular Branch with Special References to the Mastoid Canaliculus for the Nerve: A Study Using Human Fetus Histological Sections","volume":"259","author":"Kim","year":"2025","journal-title":"Ann. Anat. Anat. Anz."},{"key":"ref_5","unstructured":"Standring, S., Anand, N., Birch, R., Collins, P., Crossman, A., Gleeson, M., Jawaheer, G., Smith, A., Spratt, J., and Stringer, M. (2016). Gray\u2019s Anatomy: The Anatomical Basis of Clinical Practice, Elsevier. [41st ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Yamamoto, M., Abe, H., Hirouchi, H., Sato, M., Murakami, G., Rodr\u00edguez-V\u00e1zquez, J.F., and Abe, S. (2021). Development of the Cartilaginous Connecting Apparatuses in the Fetal Sphenoid, with a Focus on the Alar Process. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0251068"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1469-7998.1885.tb07864.x","article-title":"On the Development and Morphology of the Human Sphenoid Bone","volume":"308","author":"Sutton","year":"1885","journal-title":"Proc. Zool. Soc. Lond."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1002\/ar.23833","article-title":"Early Fetal Development of the Otic and Pterygopalatine Ganglia with Special Reference to the Topographical Relationship with the Developing Sphenoid Bone","volume":"301","author":"Yamamoto","year":"2018","journal-title":"Anat. Rec."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00276-022-02935-6","article-title":"Letter to the Editor: \u201cPterygospinous and Pterygoalar Bars in Children\u201d","volume":"44","author":"Cho","year":"2022","journal-title":"Surg. Radiol. Anat."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Li, Z., Jin, Z.-W., Li, C.-A., Yamamoto, M., Murakami, G., Rodr\u00edguez-V\u00e1zquez, J.F., and Hayashi, S. (2025). Orbital Roof Cartilage and Bone in Human Fetuses with Special Reference to Changing Territories among the Ala Minor of the Sphenoid, Frontal Bone, and Ethmoid. Anat. Cell Biol., in press.","DOI":"10.5115\/acb.25.100"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00381-017-3482-2","article-title":"Martin Heinrich Rathke (1793\u20131860) and His Pouch and Cyst","volume":"34","author":"Chun","year":"2018","journal-title":"Child\u2019s Nerv. Syst."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/joa.13515","article-title":"Association between the Developing Sphenoid and Adult Morphology: A Study Using Sagittal Sections of the Skull Base from Human Embryos and Fetuses","volume":"239","author":"Yamamoto","year":"2021","journal-title":"J. Anat."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Grzonkowska, M., Baumgart, M., and Szpinda, M. (2024). Quantitative Study of the Ossification Centers of the Body of Sphenoid Bone in the Human Fetus. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-64550-2"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1741-4520.2011.00322.x","article-title":"Morphological and Morphometric Study on Sphenoid and Basioccipital Ossification in Normal Human Fetuses","volume":"51","author":"Zhang","year":"2011","journal-title":"Congenit. Anom."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2535\/ofaj1936.41.2-3_159","article-title":"Developmental Studies on the Presphenoid in the Human Sphenoid Bone","volume":"41","author":"Kodama","year":"1965","journal-title":"Okajimas Folia Anat. Jpn."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3171\/2018.9.PEDS18481","article-title":"The Caroticoclinoid Foramen in Fetal and Infantile Orbitosphenoid, Presphenoid, and Sphenoid Bones: Developmental and Neurosurgical Considerations","volume":"23","author":"Zdilla","year":"2019","journal-title":"J. Neurosurg. Pediatr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0887-2171(05)80076-9","article-title":"Laine Imaging the Sphenoid Bone and Basiocciput: Anatomic Considerations","volume":"14","author":"Kuta","year":"1993","journal-title":"Semin. Ultrasound CT MRI"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.5115\/acb.24.218","article-title":"Ossification of Bony Nerve Canals in the Human Head: A Comparison between the Endochondral and Membranous Bones","volume":"58","author":"Li","year":"2025","journal-title":"Anat. Cell Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/(SICI)1096-8644(199812)107:4<387::AID-AJPA2>3.0.CO;2-Y","article-title":"The Posterior Border of the Sphenoid Greater Wing and Its Phylogenetic Usefulness in Human Evolution","volume":"107","author":"Braga","year":"1998","journal-title":"Am. J. Phys. Anthropol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ar.1092330312","article-title":"Development of the Human Sphenomandibular Ligament","volume":"233","author":"Vazquez","year":"1992","journal-title":"Anat. Rec."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/joa.13974","article-title":"Sphenomandibular Ligament and Degenerating Meckel\u2019s Cartilage Revisited: Sequential Variations with Temporal Bone Deformity for Ligament Attachment in Near-Term Human Fetuses","volume":"244","author":"Jin","year":"2024","journal-title":"J. Anat."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5115\/acb.20.310","article-title":"Fetal Development of the Carotid Canal with Special Reference to a Contribution of the Sphenoid Bone and Pharyngotympanic Tube","volume":"54","author":"Honkura","year":"2021","journal-title":"Anat. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2478\/acb-2023-0011","article-title":"Clinical Anatomy of the Sphenoid Bone and Its Terminology","volume":"11","author":"Chmielewski","year":"2023","journal-title":"Med. J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00276-023-03226-4","article-title":"A Morphological Study on the Sphenoid Bone Ligaments\u2019 Ossification Pattern","volume":"45","author":"Piagkou","year":"2023","journal-title":"Surg. Radiol. Anat."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Iskra, T., Stachera, B., Mo\u017cd\u017ce\u0144, K., Murawska, A., Ostrowski, P., Bonczar, M., Gregorczyk-Maga, I., Walocha, J., Koziej, M., and Wysiadecki, G. (2023). Morphology of the Sella Turcica: A Meta-Analysis Based on the Results of 18,364 Patients. Brain Sci., 13.","DOI":"10.3390\/brainsci13081208"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jcms.2018.01.008","article-title":"Incidence and Morphometry of Sellar Bridges and Related Foramina in Dry Skulls: Their Significance in Middle Cranial Fossa Surgery","volume":"46","author":"Natsis","year":"2018","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nikolova, S., Toneva, D., Zlatareva, D., and Fileva, N. (2023). Osseous Bridges of the Sphenoid Bone: Frequency, Bilateral and Sex Distribution. Biology, 12.","DOI":"10.3390\/biology12040492"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/ocr.12426","article-title":"Sella Turcica Morphology in Patients with Genetic Syndromes: A Systematic Review","volume":"24","author":"Roomaney","year":"2021","journal-title":"Orthod. Craniofacial Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ejo\/cjs091","article-title":"Sella Turcica Morphology and the Pituitary Gland\u2014A New Contribution to Craniofacial Diagnostics Based on Histology and Neuroradiology","volume":"37","year":"2015","journal-title":"Eur. J. Orthod."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3171\/jns.2007.106.1.170","article-title":"Anatomical Variations in Pneumatization of the Anterior Clinoid Process","volume":"106","author":"Mikami","year":"2007","journal-title":"J. Neurosurg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"E200","DOI":"10.1093\/ons\/opaa374","article-title":"Surgical Relevance of Pediatric Anterior Clinoid Process Maturation for Anterior Skull Base Approaches","volume":"20","author":"Rennert","year":"2021","journal-title":"Oper. Neurosurg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3171\/2017.2.JNS162114","article-title":"A Morphometric Survey of the Parasellar Region in More than 2700 Skulls: Emphasis on the Middle Clinoid Process Variants and Implications in Endoscopic and Microsurgical Approaches","volume":"129","author":"Sharma","year":"2018","journal-title":"J. Neurosurg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-0031-1287678","article-title":"Qualitative and Quantitative Radio-Anatomical Variation of the Posterior Clinoid Process","volume":"21","author":"Salma","year":"2011","journal-title":"Skull Base"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Triantafyllou, G., Paschopoulos, I., Luzzi, S., Tsakotos, G., Papadopoulos-Manolarakis, P., Galzio, R., and Piagkou, M. (2025). Prevalence and Morphology of Ossified Caroticoclinoid Ligament: An Updated Systematic Review with Meta-Analysis. Diagnostics, 15.","DOI":"10.3390\/diagnostics15040440"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Paschopoulos, I., Triantafyllou, G., Papadopoulos-Manolarakis, P., Luzzi, S., Karangeli, N., Tsakotos, G., Galzio, R., and Piagkou, M. (2024). The Morphological Stenosis Pattern of the Caroticoclinoid Foramen. Diagnostics, 15.","DOI":"10.3390\/diagnostics15010076"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1227\/ons.0000000000001258","article-title":"The Coexistence of Carotico-Clinoid Foramen and Interclinoidal Osseous Bridge: An Anatomo-Radiological Study with Surgical Implications","volume":"28","author":"Serioli","year":"2025","journal-title":"Oper. Neurosurg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/SCS.0000000000002285","article-title":"Circularity, Solidity, Axes of a Best Fit Ellipse, Aspect Ratio, and Roundness of the Foramen Ovale","volume":"27","author":"Zdilla","year":"2016","journal-title":"J. Craniofacial Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12565-025-00826-5","article-title":"Foramen Ovale Morphology and Relationship with the Lateral Pterygoid Process Plate: Proposal for a New Classification System","volume":"100","author":"Triantafyllou","year":"2025","journal-title":"Anat. Sci. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s10143-021-01715-x","article-title":"Anatomical Relationship between the Foramen Ovale and the Lateral Plate of the Pterygoid Process: Application to Percutaneous Treatments of Trigeminal Neuralgia","volume":"45","author":"Iwanaga","year":"2022","journal-title":"Neurosurg. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1097\/MS9.0000000000000609","article-title":"Morphometric Analysis of Foramen Ovale, Foramen Spinosum, and Foramen Rotundum of Human Skull Using Computed Tomography Scan: A Cross-Sectional Study","volume":"85","author":"Bhattarai","year":"2023","journal-title":"Ann. Med. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Sugano, G.T., Pauris, C.C., Silva, Y.B.E., Pandini, F.E., Palermo, R.B.S., Buchaim, D.V., Buchaim, R.L., Chacon, E.L., Aparecida de Castro, C., and Pagani, B.T. (2022). Topographic and Morphometric Study of the Foramen Spinosum of the Skull and Its Clinical Correlation. Medicina, 58.","DOI":"10.3390\/medicina58121740"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s00276-011-0810-1","article-title":"Doubled Foramen Rotundum and Maxillary Nerve Fenestration","volume":"33","author":"Rusu","year":"2011","journal-title":"Surg. Radiol. Anat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1097\/SCS.0000000000011118","article-title":"Concomitant Sphenopterygoid Canal and Duplicated Foramen Rotundum Detected on Computed Tomography Scan","volume":"36","author":"Triantafyllou","year":"2025","journal-title":"J. Craniofacial Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.morpho.2021.11.004","article-title":"Duplication of the Foramen Rotundum: A Rare Case Report","volume":"107","author":"Syed","year":"2023","journal-title":"Morphologie"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/SCS.0000000000001597","article-title":"Is There a Relationship Between Optic Canal, Foramen Rotundum, and Vidian Canal?","volume":"26","author":"Inal","year":"2015","journal-title":"J. Craniofacial Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5152\/tao.2017.2038","article-title":"Vidian Canal Types and Dehiscence of the Bony Roof of the Canal: An Anatomical Study","volume":"55","author":"Yegin","year":"2017","journal-title":"Turk Otolarengoloji Ars.\/Turk. Arch. Otolaryngol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e826","DOI":"10.1016\/j.wneu.2023.10.140","article-title":"Optic Canal Size Is an Indicator for the Accessory Optic Canal: Applications for Anterior Clinoidectomy","volume":"181","author":"Zdilla","year":"2024","journal-title":"World Neurosurg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100952","DOI":"10.1016\/j.morpho.2025.100952","article-title":"A Rare Morphological Variant: Bilateral Accessory Optic Canal","volume":"109","author":"Triantafyllou","year":"2025","journal-title":"Morphologie"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/01676830.2018.1528619","article-title":"Anatomic Variation of the Entrance of the Optic Canal into the Orbit","volume":"38","author":"Ugradar","year":"2019","journal-title":"Orbit"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1227\/00006123-199504000-00018","article-title":"Microsurgical Anatomy of the Superior Orbital Fissure","volume":"36","author":"Natori","year":"1995","journal-title":"Neurosurgery"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s12565-022-00687-2","article-title":"Morphometric Evaluation and Classification of the Superior Orbital Fissure on 3D MDCT Images","volume":"98","author":"Pirinc","year":"2023","journal-title":"Anat. Sci. Int."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01630898","article-title":"The Superior Orbital Fissure and Its Contents","volume":"21","author":"Govsa","year":"1999","journal-title":"Surg. Radiol. Anat."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00276-022-03051-1","article-title":"The Sphenoidal Emissary Foramina Prevalence: A Meta-Analysis of 6,369 Subjects","volume":"45","author":"Piagkou","year":"2022","journal-title":"Surg. Radiol. Anat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/ca.23504","article-title":"The Sphenoidal Emissary Foramen and the Emissary Vein: Anatomy and Clinical Relevance","volume":"33","author":"Leonel","year":"2020","journal-title":"Clin. Anat."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00276-025-03601-3","article-title":"An Accessory Sphenoidal Foramen of the Middle Cranial Fossa Detected on Computed Tomography","volume":"47","author":"Triantafyllou","year":"2025","journal-title":"Surg. Radiol. Anat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00276-024-03353-6","article-title":"The Sphenopterygoid Canal and Pterygoid Foramen","volume":"46","author":"Rusu","year":"2024","journal-title":"Surg. Radiol. Anat."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"151466","DOI":"10.1016\/j.aanat.2020.151466","article-title":"The Pterygospinous and Pterygoalar Ligaments and Their Relationship to the Mandibular Nerve: Application to a Better Understanding of Various Forms of Trigeminal Neuralgia","volume":"229","author":"Iwanaga","year":"2020","journal-title":"Ann. Anat."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.jcms.2017.06.019","article-title":"The Pterygoalar Bar: A Meta-Analysis of Its Prevalence, Morphology and Morphometry","volume":"45","author":"Henry","year":"2017","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"ons60","DOI":"10.1227\/01.NEU.0000345952.64041.9C","article-title":"Ossification of ligaments near the foramen ovale","volume":"65","author":"Tubbs","year":"2009","journal-title":"Oper. Neurosurg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.3171\/2019.2.JNS182709","article-title":"Ossification of the Pterygoalar and Pterygospinous Ligaments: A Computed Tomography Analysis of Infratemporal Fossa Anatomical Variants Relevant to Percutaneous Trigeminal Rhizotomy","volume":"132","author":"Matys","year":"2020","journal-title":"J. Neurosurg."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00276-019-02305-9","article-title":"Prevalence, Morphology, and Morphometry of the Pterygospinous Bar: A Meta-Analysis","volume":"42","author":"Henry","year":"2020","journal-title":"Surg. Radiol. Anat."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00276-021-02853-z","article-title":"Pterygospinous and Pterygoalar Bars in Children","volume":"44","author":"Esen","year":"2022","journal-title":"Surg. Radiol. Anat."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Simonds, E., Iwanaga, J., Oskouian, R.J., and Tubbs, R.S. (2017). Duplication of the Sphenomandibular Ligament. Cureus, 9.","DOI":"10.7759\/cureus.1783"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1016\/j.wneu.2014.09.021","article-title":"Endoscopic, Endonasal Variability in the Anatomy of the Internal Carotid Artery","volume":"82","author":"Cebula","year":"2014","journal-title":"World Neurosurg."},{"key":"ref_65","first-page":"e251","article-title":"Comparative Analysis of Surgical Working Corridors for Meckel Cave Trigeminal Schwannomas: A Quantitative Anatomic Study","volume":"25","author":"Luzzi","year":"2023","journal-title":"Oper. Neurosurg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.anorl.2020.12.009","article-title":"Endonasal Endoscopic Approach to the Pterygopalatine and Infratemporal Fossae","volume":"138","author":"Karkas","year":"2021","journal-title":"Eur. Ann. Otorhinolaryngol. Head Neck Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/ca.23693","article-title":"Comprehensive Review of Lower Third Molar Management: A Guide for Improved Informed Consent","volume":"34","author":"Iwanaga","year":"2021","journal-title":"Clin. Anat."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/8\/1090\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:32:00Z","timestamp":1760034720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/8\/1090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":67,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["biology14081090"],"URL":"https:\/\/doi.org\/10.3390\/biology14081090","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]}}}