{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:38:21Z","timestamp":1760060301140,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretariat of Science Humanities, Technology, and Innovation (SECIHTI)","award":["RENAJEB-2023-17","PAPIIT-IN224324"],"award-info":[{"award-number":["RENAJEB-2023-17","PAPIIT-IN224324"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","award":["RENAJEB-2023-17","PAPIIT-IN224324"],"award-info":[{"award-number":["RENAJEB-2023-17","PAPIIT-IN224324"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Congenital developmental defects are among the postnatal consequences of early exposure to hydrogen peroxide or other teratogens that induce oxidative stress, highlighting a potential mechanistic link between oxidative stress, redox signaling, and developmental processes. This study evaluated the morphological and behavioral abnormalities induced by hydrogen peroxide in the Drosophila melanogaster model, as well as its teratogenic index. The results demonstrated that hydrogen peroxide induces morphological abnormalities in adult wings, legs, and abdomen, as well as necrosis and developmental disruptions during larval and pupal stages. A median lethal concentration (LC50) of 0.16% and a teratogenic index (TI) of 0.44 were calculated when considering anomalies at any development stage; a TI of 0.21 was obtained when considering only adult abnormalities. Regarding behavioral changes, an increase in locomotor activity was observed in both larvae and adults, with significantly greater activity recorded in adult females than in males. These findings suggest that hydrogen peroxide can induce both morphological and behavioral abnormalities in D. melanogaster, although it presents a low teratogenic index.<\/jats:p>","DOI":"10.3390\/biology14091122","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:25:57Z","timestamp":1756189557000},"page":"1122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morphological and Behavioral Abnormalities Induced by Hydrogen Peroxide in Drosophila melanogaster"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5086-8181","authenticated-orcid":false,"given":"Mar\u00eda Llasbeth","family":"Hern\u00e1ndez-Calder\u00f3n","sequence":"first","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Laboratorio de Citogen\u00e9tica Humana, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. 1o de Mayo S\/N, Santa Mar\u00eda las Torres, Cuautitl\u00e1n Izcalli 54740, Mexico"},{"name":"Centro de Estudios e Investigaciones Interdisciplinarias, Universidad Aut\u00f3noma de Coahuila, Centro Cultural 2\u00b0 piso, Ciudad Universitaria, Carretera M\u00e9xico km. 13, Arteaga 25350, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alondra","family":"Gallegos-Moreno","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Laboratorio de Citogen\u00e9tica Humana, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. 1o de Mayo S\/N, Santa Mar\u00eda las Torres, Cuautitl\u00e1n Izcalli 54740, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneet Yamely","family":"Miranda-Camacho","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Laboratorio de Citogen\u00e9tica Humana, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. 1o de Mayo S\/N, Santa Mar\u00eda las Torres, Cuautitl\u00e1n Izcalli 54740, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Linette","family":"S\u00e1nchez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Laboratorio de Citogen\u00e9tica Humana, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. 1o de Mayo S\/N, Santa Mar\u00eda las Torres, Cuautitl\u00e1n Izcalli 54740, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2329-2857","authenticated-orcid":false,"given":"Sandra","family":"D\u00edaz-Barriga-Arceo","sequence":"additional","affiliation":[{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Laboratorio de Citogen\u00e9tica Humana, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Av. 1o de Mayo S\/N, Santa Mar\u00eda las Torres, Cuautitl\u00e1n Izcalli 54740, Mexico"},{"name":"Facultad de Estudios Superiores Cuautitl\u00e1n, Laboratorio de Gen\u00e9tica y Toxicolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Carretera Cuautitl\u00e1n-Teoloyucan Km. 2.5, Cuautitl\u00e1n Izcalli 54714, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6298-4207","authenticated-orcid":false,"given":"Jorge Alejandro","family":"Aguirre-Joya","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n y Jard\u00edn Etnobiol\u00f3gico, Universidad Aut\u00f3noma de Coahuila, Dr. Francisco Gonz\u00e1lez # 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