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Liraglutide (LGT), a GLP-1 agonist, could be a potential therapeutic option. We investigated the impact of a chronic high-salt diet (HSD) on VAT homeostasis and evaluated the potential protective effects of LGT, a GLP-1 receptor agonist. Male C57BL\/6 mice were fed a standard diet (Control, C) or 8% NaCl (HSD) for 15 weeks and subsequently treated with LGT or vehicle for 5 weeks. In VAT, histological characteristics, collagen deposition, vascular density, mitochondrial dynamics, oxidative stress, and adipokine expression were evaluated. The HSD significantly decreased body weight, VAT mass, and adipocyte size (p &lt; 0.05). Moreover, it impaired vascular density and induced interstitial fibrosis (p &lt; 0.01). LGT treatment improved vascularization and VEGF expression and reduced fibrosis (p &lt; 0.05 vs. the HSD). The HSD induced oxidative stress and mitochondrial fragmentation, which were attenuated by LGT (p &lt; 0.001). Leptin levels were elevated by the HSD (p &lt; 0.05) and normalized with LGT, while adiponectin levels increased. In conclusion, excessive salt consumption induces structural and metabolic dysfunction in VAT. LGT therapy mitigates several of these adverse effects, supporting its potential as a novel strategy for managing salt-sensitive adipose tissue dysfunction.<\/jats:p>","DOI":"10.3390\/biology14091171","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T08:23:38Z","timestamp":1756801418000},"page":"1171","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["High Salt Intake Affects Visceral Adipose Tissue Homeostasis: Beneficial Effects of GLP-1 Agonists"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2230-1552","authenticated-orcid":false,"given":"Vanessa","family":"Touceda","sequence":"first","affiliation":[{"name":"Laboratorio de Patolog\u00eda Cardiovascular Experimental e Hipertensi\u00f3n Arterial, Instituto de Investigaciones Biom\u00e9dicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Cat\u00f3lica Argentina, Buenos Aires C1107AFF, Argentina"},{"name":"Unidad de Investigaci\u00f3n en Bioqu\u00edmica Traslacional y Metabolismo (UBiTyM), C\u00e1tedra de Bioqu\u00edmica General y Bucal, Facultad de Odontolog\u00eda, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cacciagi\u00fa","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Bioqu\u00edmica Traslacional y Metabolismo (UBiTyM), C\u00e1tedra de Bioqu\u00edmica General y Bucal, Facultad de Odontolog\u00eda, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina"},{"name":"Secci\u00f3n Bioqu\u00edmica, Laboratorio Central, Hospital General de Agudos Teodoro \u00c1lvarez, Buenos Aires C1107AFF, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5515-9850","authenticated-orcid":false,"given":"Ignacio 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Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Cat\u00f3lica Argentina, Buenos Aires C1107AFF, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-6020","authenticated-orcid":false,"given":"Romina C.","family":"De Lucca","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Histolog\u00eda y Embriolog\u00eda, Facultad de Odontolog\u00eda, Universidad de Buenos Aires, Buenos Aires C1107AFF, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agustina","family":"Vidal","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biom\u00e9dicas (UCA-CONICET), Facultad de Medicina, Pontificia Universidad Cat\u00f3lica Argentina, Buenos Aires C1107AFF, 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Intern. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"f1325","DOI":"10.1136\/bmj.f1325","article-title":"Effect of longer-term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomized trials","volume":"346","author":"He","year":"2013","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0140-6736(11)61174-4","article-title":"Salt reduction lowers cardiovascular risk: Metaanalysis of outcome trials","volume":"378","author":"He","year":"2011","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Garofalo, C., Borrelli, S., Provenzano, M., De Stefano, T., Vita, C., Chiodini, P., Minutolo, R., De Nicola, L., and Conte, G. (2018). Dietary salt restriction in chronic kidney disease: A meta-analysis of randomized clinical trials. Nutrients, 10.","DOI":"10.3390\/nu10060732"},{"key":"ref_5","unstructured":"World Health Organization (2012). Guideline: Sodium Intake for Adults and Children, World Health Organization."},{"key":"ref_6","unstructured":"Ministerio de Salud y Desarrollo Social (2019). Encuesta Nacional de Factores de Riesgo, Ministerio de Salud y Desarrollo Social."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"s6","DOI":"10.1017\/S136898002200218X","article-title":"Population-level salt intake in the WHO European Region in 2022: A systematic review","volume":"26","author":"Kwong","year":"2023","journal-title":"Public Health Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s11906-019-0948-5","article-title":"The Influence of Dietary Salt Beyond Blood Pressure","volume":"21","author":"Robinson","year":"2019","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.3346\/jkms.2014.29.S2.S87","article-title":"Estimation of daily salt intake through a 24-hour urine collection in Pohang, Korea","volume":"29","author":"Kim","year":"2014","journal-title":"J. Korean Med. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1017\/S0007114516003391","article-title":"Dietary sodium and potassium intake in relation to non-alcoholic fatty liver disease","volume":"116","author":"Choi","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI88532","article-title":"High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation","volume":"127","author":"Kitada","year":"2017","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"White, U. (2023). Adipose tissue expansion in obesity, health, and disease. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1188844"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tcb.2021.10.008","article-title":"Mitochondrial regulation and white adipose tissue homeostasis","volume":"32","author":"Zhu","year":"2022","journal-title":"Trends Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.numecd.2013.08.007","article-title":"Effect of insulin-resistance on circulating and adipose tissue MMP-2 and MMP-9 activity in rats fed a sucrose-rich diet","volume":"24","author":"Miksztowicz","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41387-020-0127-4","article-title":"Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: What is the best choice?","volume":"10","author":"Carvajal","year":"2020","journal-title":"Nutr. Diabetes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-060721-092930","article-title":"Adipose Tissue Fibrosis in Obesity: Etiology and Challenges","volume":"84","author":"Marcelin","year":"2022","journal-title":"Annu. Rev. Physiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1161\/CIRCRESAHA.121.318093","article-title":"Obesity, Adipose Tissue and Vascular Dysfunction","volume":"128","author":"Koenen","year":"2021","journal-title":"Circ. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100185","DOI":"10.1016\/j.crphar.2024.100185","article-title":"Liraglutide improves adipose tissue remodeling and mitochondrial dynamics in a visceral obesity model induced by a high-fat diet","volume":"6","author":"Touceda","year":"2024","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1038\/oby.2008.69","article-title":"High sodium intake enhances insulin-stimulated glucose uptake in rat epididymal adipose tissue","volume":"16","author":"Takada","year":"2008","journal-title":"Obesity"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cmet.2016.02.019","article-title":"Sodium Intake Regulates Glucose Homeostasis through the PPAR\u03b4\/Adiponectin-Mediated SGLT2 Pathway","volume":"23","author":"Zhao","year":"2016","journal-title":"Cell Metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.2174\/1871530320666200515112853","article-title":"Obesity: The New Global Epidemic Pharmacological Treatment, Opportunities and Limits for Personalized Therapy","volume":"20","author":"Milano","year":"2020","journal-title":"Endocr. Metab. Immune Disord.-Drug Targets"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1586\/14779072.2015.1054810","article-title":"Liraglutide for Type 2 diabetes and obesity: A 2015 update","volume":"13","author":"Iepsen","year":"2015","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_23","unstructured":"FDA (2024, December 12). US Food & Drug Administration, Available online: https:\/\/web.archive.org\/web\/20130307084113\/http:\/\/www.fda.gov\/NewsEvents\/Newsroom\/PressAnnouncements\/2010\/ucm198638.htm."},{"key":"ref_24","unstructured":"FDA (2024, December 12). US Food & Drug Administration, Available online: https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/fda-approves-weight-management-drug-patients-aged-12-and-older."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like peptide 1 (GLP-1)","volume":"30","author":"Finan","year":"2019","journal-title":"Mol. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rowlands, J., Heng, J., Newsholme, P., and Carlessi, R. (2018). Pleiotropic Effects of GLP-1 and Analogs on Cell Signaling, Metabolism, and Function. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00672"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1074\/jbc.M111.310342","article-title":"Regulation of adipocyte formation by GLP-1\/GLP-1R signaling","volume":"287","author":"Challa","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_28","first-page":"4499","article-title":"Liraglutide suppresses proliferation and induces adipogenic differentiation of 3T3-L1 cells via the Hippo-YAP signaling pathway","volume":"17","author":"Li","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tamura, K., Minami, K., Kudo, M., Iemoto, K., Takahashi, H., and Seino, S. (2015). Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0126003"},{"key":"ref_30","first-page":"4818","article-title":"Liraglutide improves pancreatic islet \u03b2 cell apoptosis in rats with type 2 diabetes mellitus by inhibiting the IKK\u03b5\/NF-\u03baB pathway","volume":"25","author":"Liu","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol Sci."},{"key":"ref_31","unstructured":"National Research Council (2012). Guide for the Care and Use of Laboratory Animals, The National Academies Press. [8th ed.]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"H1287","DOI":"10.1152\/ajpheart.00096.2016","article-title":"Cardiac-deleterious role of galectin-3 in chronic angiotensin II-induced hypertension","volume":"311","author":"Rhaleb","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1152\/ajplegacy.1967.212.4.777","article-title":"Morphological changes in the adipocyte during fat deposition and mobilization","volume":"212","author":"Goldrick","year":"1967","journal-title":"Am. J. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/bs.mcb.2017.08.008","article-title":"Measurement of elastin, collagen, and total protein levels in tissues","volume":"143","author":"Stoilov","year":"2018","journal-title":"Methods Cell Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"353","DOI":"10.33594\/000000556","article-title":"Genetic Deletion of Galectin-3 Exacerbates Age-Related Myocardial Hypertrophy and Fibrosis in Mice","volume":"56","author":"Estevez","year":"2022","journal-title":"Cell Physiol. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Chanmuang, S., Kim, B.M., Gu, S.Y., Son, Y.J., Le, H.G., Nam, Y.D., Song, E.J., Ham, K.S., and Kim, H.J. (2022). Effects of sea salt intake on metabolites, steroid hormones, and gut microbiota in rats. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0269014"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Tian, H., Gao, X., Du, H., Lin, Z., and Huang, X. (2025). Changes in microbial and metabolic profiles of mice fed with long-term high salt diet. BMC Gastroenterol., 25.","DOI":"10.1186\/s12876-025-03929-5"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00125-016-3933-4","article-title":"Adipose tissue plasticity: How fat depots respond differently to pathophysiological cues","volume":"59","author":"Pellegrinelli","year":"2016","journal-title":"Diabetologia"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cmet.2013.06.016","article-title":"Fibrosis and adipose tissue dysfunction","volume":"18","author":"Sun","year":"2013","journal-title":"Cell Metab."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Durango, N., Fuentes, C.A., Castillo, A.E., Gonz\u00e1lez-G\u00f3mez, L.M., Vecchiola, A., Fardella, C.E., and Kalergis, A.M. (2016). Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17070797"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"F654","DOI":"10.1152\/ajprenal.00396.2021","article-title":"Interleukin-6 blockade reduces salt-induced cardiac inflammation and fibrosis in subtotal nephrectomized mice","volume":"323","author":"Tanaka","year":"2022","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/oby.20716","article-title":"High-salt intake induced visceral adipose tissue hypoxia and its association with circulating monocyte subsets in humans","volume":"22","author":"Zhou","year":"2014","journal-title":"Obesity"},{"key":"ref_43","first-page":"17","article-title":"Expression of hypoxia-inducible factor-1alpha (HIF-1alpha) related to oxidative stress in liver of rat-induced by systemic chronic normobaric hypoxia","volume":"42","author":"Jusman","year":"2010","journal-title":"Acta Med. Indones."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1080\/10715762.2020.1870685","article-title":"Feedback of hypoxia-inducible factor-1alpha (HIF-1alpha) transcriptional activity via redox factor-1 (Ref-1) induction by reactive oxygen species (ROS)","volume":"55","author":"Kobayashi","year":"2021","journal-title":"Free. Radic. Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Korbecki, J., Simi\u0144ska, D., G\u0105ssowska-Dobrowolska, M., Listos, J., Gutowska, I., Chlubek, D., and Baranowska-Bosiacka, I. (2021). Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-\u03baB Activation: A Review of the Molecular Mechanisms. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms221910701"},{"key":"ref_46","first-page":"201","article-title":"GLP-1 agonists and insulin resistance: Effects of Liraglutide on adipose tissue remodeling. LXIV Reuni\u00f3n Anual de la Sociedad Argentina de Investigaci\u00f3n Cl\u00ednica (SAIC)","volume":"79","author":"Touceda","year":"2019","journal-title":"Fund. Rev. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Yanes, B., and Rainero, E. (2022). The Interplay between Cell-Extracellular Matrix Interaction and Mitochondria Dynamics in Cancer. Cancers, 14.","DOI":"10.3390\/cancers14061433"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/1873-3468.14077","article-title":"Mitochondrial dynamics in health and disease","volume":"595","author":"Yapa","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"E209","DOI":"10.1210\/jc.2013-3042","article-title":"Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size","volume":"99","author":"Yin","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.RES.0000258450.44413.96","article-title":"Mitochondrial dysfunction in atherosclerosis","volume":"100","author":"Madamanchi","year":"2007","journal-title":"Circ. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"F619","DOI":"10.1152\/ajprenal.00388.2002","article-title":"Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity","volume":"285","author":"Dobrian","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","article-title":"High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria","volume":"416","author":"Korshunov","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.freeradbiomed.2011.06.022","article-title":"Uncoupling proteins and the control of mitochondrial reactive oxygen species production","volume":"51","author":"Mailloux","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","article-title":"Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human","volume":"150","author":"Wu","year":"2012","journal-title":"Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/dom.14980","article-title":"The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease","volume":"25","author":"Wu","year":"2023","journal-title":"Diabetes Obes. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Baldelli, S., Aiello, G., Mansilla Di Martino, E., Campaci, D., Muthanna, F.M.S., and Lombardo, M. (2024). The Role of Adipose Tissue and Nutrition in the Regulation of Adiponectin. 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