{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:31:35Z","timestamp":1792762295381,"version":"4.5.0"},"reference-count":111,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS2025-00517677"],"award-info":[{"award-number":["RS2025-00517677"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Biology"],"abstract":"<jats:p>The liver has a notable regenerative capacity, primarily through hepatocyte proliferation. However, when this process is impaired\u2014due to severe and\/or chronic injury\u2014liver progenitor cells (LPCs) serve as a facultative reserve to restore hepatic function. LPCs, which are a bipotent and heterogeneous population located near the canals of Hering, can differentiate into hepatocytes and cholangiocytes. Recent evidence suggests that LPCs may originate from mature hepatic cells\u2014such as hepatocytes, cholangiocytes, and hepatic stellate cells\u2014through dedifferentiation under specific injury conditions. Cellular plasticity in the liver is governed by complex signaling networks that regulate LPC activation, maintenance, and lineage commitment. However, the precise cellular origin of LPCs and the mechanisms driving their activation remain incompletely defined. Therefore, this review aims to synthesize current insights into LPC biology and emphasize their diverse cellular origins, functional roles in liver regeneration, and the key signaling pathways involved. A deeper understanding of LPC dynamics may ultimately guide the development of novel therapeutic strategies to enhance liver regeneration in chronic liver disease.<\/jats:p>","DOI":"10.3390\/biology14101361","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T08:10:51Z","timestamp":1759738251000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Liver Progenitor Cells: Cellular Origins, Plasticity, and Signaling Pathways in Liver Regeneration"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5317-9409","authenticated-orcid":false,"given":"Jinsol","family":"Han","sequence":"first","affiliation":[{"name":"Institute of Systems Biology, Pusan National University, Pusan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2747-6685","authenticated-orcid":false,"given":"Ahyeon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Integrated Biological Science, College of Natural Science, Pusan National University, Pusan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2096-4419","authenticated-orcid":false,"given":"Hayeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Integrated Biological Science, College of Natural Science, Pusan National University, Pusan 46241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2189-0658","authenticated-orcid":false,"given":"Youngmi","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Systems Biology, Pusan National University, Pusan 46241, Republic of Korea"},{"name":"Department of Integrated Biological Science, College of Natural Science, Pusan National University, Pusan 46241, Republic of Korea"},{"name":"Department of Biological Sciences, College of Natural Science, Pusan National University, Pusan 46241, Republic of Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yagi, S., Hirata, M., Miyachi, Y., and Uemoto, S. 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