{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:33:49Z","timestamp":1777509229752,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012547","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2025GXNSFDA069011"],"award-info":[{"award-number":["2025GXNSFDA069011"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Natural Science Foundation Joint Special Project on Active Health and Common Diseases","award":["2024GXNSFBA010103"],"award-info":[{"award-number":["2024GXNSFBA010103"]}]},{"name":"Guangxi Young Elite Scientist Sponsorship Program","award":["GXYESS2025053"],"award-info":[{"award-number":["GXYESS2025053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Gastric diseases represent a significant challenge to global health. A comprehensive understanding of their complex molecular mechanisms, particularly the pathways of molecular progression in precancerous lesions, is essential for enhancing diagnosis and treatment. StomachDB, the first comprehensive multi-omics database dedicated to gastric diseases, has been developed to address these research needs. This database integrates 6 types of biological data: genomics, transcriptomics, emerging single-cell and spatial transcriptomics, proteomics, metabolomics, and therapeutic-related information. It encompasses 44 gastric-related pathologies, including various forms of gastric cancer, gastric ulcers, and gastritis, primarily involving humans and mice as model organisms. The database compiles approximately 2.5 million curated and standardized profiles, along with 268,394 disease-gene associations. The user-friendly analytics platform provides tools for browsing, querying, visualizing, and downloading data, facilitating systematic exploration of multi-omics features. This integrative approach addresses the limitations of single-omics analyses, such as data heterogeneity and insufficient analytical dimensions. Researchers can investigate the clinical significance of target genes (e.g., CDH1) across different omics levels and explore potential regulatory mechanisms. Furthermore, StomachDB emphasizes the discovery of therapeutic targets by cataloging interactions among chemical drugs, traditional herbal medicines, and probiotics. As an open-access resource, it serves as a powerful tool for studying complex biological interactions and regulatory mechanisms.<\/jats:p>","DOI":"10.3390\/biology14111484","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T02:50:48Z","timestamp":1761533448000},"page":"1484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["StomachDB: An Integrated Multi-Omics Database for Gastric Diseases"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7264-2457","authenticated-orcid":false,"given":"Gang","family":"Wang","sequence":"first","affiliation":[{"name":"Research Center of Oncology, Guangxi Academy of Medical Sciences, Nanning 530021, China"},{"name":"Life Sciences Institute, Guangxi Medical University, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4152-0063","authenticated-orcid":false,"given":"Zhe","family":"Sun","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, Guangxi Medical University, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9493-1436","authenticated-orcid":false,"given":"Shiou Yih","family":"Lee","sequence":"additional","affiliation":[{"name":"Faculty of Health and Life Sciences, INTI International University, Nilai 71800, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0508-2123","authenticated-orcid":false,"given":"Mingyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Shuangyong Road, Guangxi Zhuang Autonomous Region, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-9665","authenticated-orcid":false,"given":"Xiaojuan","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Northwest University, Xi\u2019an 710069, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3177-213X","authenticated-orcid":false,"given":"Sanqi","family":"An","sequence":"additional","affiliation":[{"name":"Life Sciences Institute, Guangxi Medical University, Nanning 530021, China"},{"name":"Guangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/j.gastro.2023.05.050","article-title":"Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019","volume":"165","author":"Wang","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1186\/s12967-024-05998-8","article-title":"The role of MAPK pathway in gastric cancer: Unveiling molecular crosstalk and therapeutic prospects","volume":"22","author":"Yuan","year":"2024","journal-title":"J. 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