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Dysregulation of this process has been implicated in psychiatric disorders including post-traumatic stress disorder (PTSD), which is characterized by the over-consolidation of traumatic memories. LIM kinase 1 (LIMK1), a key regulator of synaptic plasticity, is believed to play an important role in memory consolidation across hippocampal\u2013cortical circuits. In this study, we investigated the function of LIMK1 using Limk1 knockout mice. Behavioral tests such as the novel object location memory task revealed significant memory impairments in knockout animals. In vivo recordings during sleep showed disrupted communication between the hippocampus and prefrontal cortex, suggesting impaired systems-level consolidation. Furthermore, in an underwater trauma exposure model, pharmacological inhibition of LIMK1 with LIMK-i3 alleviated trauma-induced behavioral abnormalities. These findings highlight LIMK1 as a critical mediator of hippocampal\u2013cortical memory consolidation and provide experimental evidence that LIMK1 inhibition can modulate maladaptive memory processes associated with PTSD-like symptoms.<\/jats:p>","DOI":"10.3390\/biology14111560","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:14:45Z","timestamp":1762506885000},"page":"1560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LIMK1 Deficiency Disrupts Hippocampal\u2013Cortical Memory Consolidation and Attenuates Trauma-Induced PTSD-like Behavior"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-3657","authenticated-orcid":false,"given":"Xiangyu","family":"Yang","sequence":"first","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China"},{"name":"Chongqing Research Institute, Shanghai Jiao Tong University, Chongqing 401151, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7696-8024","authenticated-orcid":false,"given":"Zhengping","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Electronic Science and Engineering, Nanjing University, Nanjing 210000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziying","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China"},{"name":"School of Psychology, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-4339","authenticated-orcid":false,"given":"Shuting","family":"Xia","sequence":"additional","affiliation":[{"name":"Cancer Institute, Suzhou Medical College, Soochow University, Suzhou 215021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5384-4838","authenticated-orcid":false,"given":"Weidong","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China"},{"name":"Global Institute of Future Technology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqin","family":"He","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Squire, L.R., Genzel, L., Wixted, J.T., and Morris, R.G. (2015). Memory consolidation. Cold Spring Harb. Perspect. Biol., 7.","key":"ref_1","DOI":"10.1101\/cshperspect.a021766"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.tics.2024.02.002","article-title":"Coupled sleep rhythms for memory consolidation","volume":"28","author":"Staresina","year":"2024","journal-title":"Trends Cogn. Sci."},{"doi-asserted-by":"crossref","unstructured":"Rosenberg, T., Gal-Ben-Ari, S., Dieterich, D.C., Kreutz, M.R., Ziv, N.E., Gundelfinger, E.D., and Rosenblum, K. (2014). The roles of protein expression in synaptic plasticity and memory consolidation. Front. Mol. Neurosci., 7.","key":"ref_3","DOI":"10.3389\/fnmol.2014.00086"},{"doi-asserted-by":"crossref","unstructured":"Lamprecht, R. (2021). Actin Cytoskeleton Role in the Maintenance of Neuronal Morphology and Long-Term Memory. Cells, 10.","key":"ref_4","DOI":"10.3390\/cells10071795"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/s41593-019-0467-3","article-title":"Mechanisms of systems memory consolidation during sleep","volume":"22","author":"Klinzing","year":"2019","journal-title":"Nat. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nlm.2018.04.004","article-title":"Hippocampal coupling with cortical and subcortical structures in the context of memory consolidation","volume":"160","author":"Skelin","year":"2019","journal-title":"Neurobiol. Learn. Mem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1126\/science.aan6203","article-title":"Learning-enhanced coupling between ripple oscillations in association cortices and hippocampus","volume":"358","author":"Khodagholy","year":"2017","journal-title":"Science"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nn.4304","article-title":"Hippocampo-cortical coupling mediates memory consolidation during sleep","volume":"19","author":"Maingret","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn.4457","article-title":"A cortical-hippocampal-cortical loop of information processing during memory consolidation","volume":"20","author":"Rothschild","year":"2017","journal-title":"Nat. Neurosci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.pneurobio.2006.06.004","article-title":"Molecular and systems mechanisms of memory consolidation and storage","volume":"79","author":"Wang","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.neuron.2023.03.005","article-title":"Sleep-A brain-state serving systems memory consolidation","volume":"111","author":"Brodt","year":"2023","journal-title":"Neuron"},{"doi-asserted-by":"crossref","unstructured":"Yang, X., Wang, X., Zou, Y., Zhang, S., Xia, M., Fu, L., Vollger, M.R., Chen, N.C., Taylor, D.J., and Harvey, W.T. (2023). Characterization of large-scale genomic differences in the first complete human genome. Genome Biol., 24.","key":"ref_12","DOI":"10.1186\/s13059-023-02995-w"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41572-021-00276-z","article-title":"Williams syndrome","volume":"7","author":"Kozel","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00109-007-0165-6","article-title":"LIM kinases: Function, regulation and association with human disease","volume":"85","author":"Scott","year":"2007","journal-title":"J. Mol. Med."},{"doi-asserted-by":"crossref","unstructured":"Ben Zablah, Y., Zhang, H., Gugustea, R., and Jia, Z. (2021). LIM-Kinases in Synaptic Plasticity, Memory, and Brain Diseases. Cells, 10.","key":"ref_15","DOI":"10.3390\/cells10082079"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1128\/MCB.01263-14","article-title":"LIMK1 regulates long-term memory and synaptic plasticity via the transcriptional factor CREB","volume":"35","author":"Todorovski","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0896-6273(02)00758-4","article-title":"Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice","volume":"35","author":"Meng","year":"2002","journal-title":"Neuron"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.neuropharm.2017.06.031","article-title":"Transient inhibition of LIMKs significantly attenuated central sensitization and delayed the development of chronic pain","volume":"125","author":"Yang","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.neuropharm.2004.06.030","article-title":"Regulation of ADF\/cofilin phosphorylation and synaptic function by LIM-kinase","volume":"47","author":"Meng","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/ijnp\/pyaa067","article-title":"LIMK1\/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice","volume":"23","author":"Gao","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1007\/s12035-016-0361-x","article-title":"Effects of Hippocampal LIMK Inhibition on Memory Acquisition, Consolidation, Retrieval, Reconsolidation, and Extinction","volume":"55","author":"Lunardi","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41582-022-00635-8","article-title":"Post-traumatic stress disorder: Clinical and translational neuroscience from cells to circuits","volume":"18","author":"Ressler","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/wps.20656","article-title":"Post-traumatic stress disorder: A state-of-the-art review of evidence and challenges","volume":"18","author":"Bryant","year":"2019","journal-title":"World Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.31083\/j.jin2301017","article-title":"Puerarin Attenuates Cycloheximide-Induced Oxidative Damage and Memory-Consolidation Impairment in Rats","volume":"23","author":"Wu","year":"2024","journal-title":"J. Integr. Neurosci."},{"key":"ref_25","first-page":"899","article-title":"Sleep Spindles Favor Emotion Regulation Over Memory Consolidation of Stressors in Posttraumatic Stress Disorder","volume":"8","author":"Natraj","year":"2023","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"zsac139","DOI":"10.1093\/sleep\/zsac139","article-title":"Sleep spindle dynamics suggest over-consolidation in post-traumatic stress disorder","volume":"45","author":"Hofman","year":"2022","journal-title":"Sleep"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1038\/s41467-019-11781-x","article-title":"Wilm\u2019s tumor 1 promotes memory flexibility","volume":"10","author":"Mariottini","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.1038\/s41380-022-01758-6","article-title":"An epigenetic mechanism for over-consolidation of fear memories","volume":"27","author":"Barchiesi","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_29","first-page":"8","article-title":"Examining object location and object recognition memory in mice","volume":"69","author":"Wood","year":"2014","journal-title":"Curr. Protoc. Neurosci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41586-020-2037-y","article-title":"Two conserved epigenetic regulators prevent healthy ageing","volume":"579","author":"Yuan","year":"2020","journal-title":"Nature"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbrc.2022.01.116","article-title":"Acute stress promotes brain oscillations and hippocampal-cortical dialog in emotional processing","volume":"598","author":"Lv","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"doi-asserted-by":"crossref","unstructured":"Ritov, G., and Richter-Levin, G. (2014). Water associated zero maze: A novel rat test for long term traumatic re-experiencing. Front. Behav. Neurosci., 8.","key":"ref_32","DOI":"10.3389\/fnbeh.2014.00001"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/31735","article-title":"Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization","volume":"393","author":"Yang","year":"1998","journal-title":"Nature"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/31729","article-title":"Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase","volume":"393","author":"Arber","year":"1998","journal-title":"Nature"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/12963","article-title":"Activation of LIM-kinase by Pak1 couples Rac\/Cdc42 GTPase signalling to actin cytoskeletal dynamics","volume":"1","author":"Edwards","year":"1999","journal-title":"Nat. Cell Biol."},{"doi-asserted-by":"crossref","unstructured":"Bailey, C.H., Kandel, E.R., and Harris, K.M. (2015). Structural Components of Synaptic Plasticity and Memory Consolidation. Cold Spring Harb. Perspect. Biol., 7.","key":"ref_36","DOI":"10.1101\/cshperspect.a021758"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2406010121","DOI":"10.1073\/pnas.2406010121","article-title":"Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function","volume":"121","author":"Bhasin","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1111\/ejn.14694","article-title":"Neurobiology of systems memory consolidation","volume":"54","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1016\/j.febslet.2015.10.032","article-title":"Roles of LIM kinases in central nervous system function and dysfunction","volume":"589","author":"Cuberos","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrn2762","article-title":"The memory function of sleep","volume":"11","author":"Diekelmann","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41583-024-00799-w","article-title":"Overnight neuronal plasticity and adaptation to emotional distress","volume":"25","author":"Cabrera","year":"2024","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1126\/science.abi8370","article-title":"Brain neural patterns and the memory function of sleep","volume":"374","author":"Girardeau","year":"2021","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1038\/s41593-022-01102-9","article-title":"Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine","volume":"25","author":"Kjaerby","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1126\/science.1063049","article-title":"The REM sleep-memory consolidation hypothesis","volume":"294","author":"Siegel","year":"2001","journal-title":"Science"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/s41593-023-01324-5","article-title":"Augmenting hippocampal-prefrontal neuronal synchrony during sleep enhances memory consolidation in humans","volume":"26","author":"Mankin","year":"2023","journal-title":"Nat. Neurosci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuron.2019.10.013","article-title":"Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice","volume":"105","author":"Steadman","year":"2020","journal-title":"Neuron"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e2207909120","DOI":"10.1073\/pnas.2207909120","article-title":"Hippocampal-cortical coupling differentiates long-term memory processes","volume":"120","author":"Dahal","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"doi-asserted-by":"crossref","unstructured":"Zhurakovskaya, E., Ishchenko, I., Gureviciene, I., Aliev, R., Gr\u00f6hn, O., and Tanila, H. (2019). Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP\/PS1 mice modeling Alzheimer\u2019s disease. Sci. Rep., 9.","key":"ref_48","DOI":"10.1038\/s41598-019-41851-5"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e13424","DOI":"10.7554\/eLife.13424","article-title":"Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1","volume":"5","author":"Havekes","year":"2016","journal-title":"eLife"},{"doi-asserted-by":"crossref","unstructured":"Medina, C., de la Fuente, V., Tom Dieck, S., Nassim-Assir, B., Dalmay, T., Bartnik, I., Lunardi, P., de Oliveira Alvares, L., Schuman, E.M., and Letzkus, J.J. (2020). LIMK, Cofilin 1 and actin dynamics involvement in fear memory processing. Neurobiol. Learn. Mem., 173.","key":"ref_50","DOI":"10.1016\/j.nlm.2020.107275"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"R179","DOI":"10.1016\/j.cub.2006.12.033","article-title":"Emotional memory: Selective enhancement by sleep","volume":"17","author":"Holland","year":"2007","journal-title":"Curr. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.smrv.2018.03.001","article-title":"Consolidative mechanisms of emotional processing in REM sleep and PTSD","volume":"41","author":"Murkar","year":"2018","journal-title":"Sleep. Med. Rev."},{"doi-asserted-by":"crossref","unstructured":"Ritov, G., Ardi, Z., and Richter-Levin, G. (2014). Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma. Front. Behav. Neurosci., 8.","key":"ref_53","DOI":"10.3389\/fnbeh.2014.00018"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/cercor\/6.2.81","article-title":"The hippocampo-neocortical dialogue","volume":"6","year":"1996","journal-title":"Cereb. Cortex"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nn1825","article-title":"Coordinated memory replay in the visual cortex and hippocampus during sleep","volume":"10","author":"Ji","year":"2007","journal-title":"Nat. Neurosci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nn.2337","article-title":"Replay of rule-learning related neural patterns in the prefrontal cortex during sleep","volume":"12","author":"Peyrache","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0896-6273(00)80629-7","article-title":"Coordinated interactions between hippocampal ripples and cortical spindles during slow-wave sleep","volume":"21","author":"Siapas","year":"1998","journal-title":"Neuron"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1038\/emboj.2010.72","article-title":"Learning, AMPA receptor mobility and synaptic plasticity depend on n-cofilin-mediated actin dynamics","volume":"29","author":"Rust","year":"2010","journal-title":"Embo J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"E9220","DOI":"10.1073\/pnas.1805517115","article-title":"Cortical circuit activity underlying sleep slow oscillations and spindles","volume":"115","author":"Niethard","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"doi-asserted-by":"crossref","unstructured":"Berabez, R., Routier, S., B\u00e9n\u00e9detti, H., Pl\u00e9, K., and Vall\u00e9e, B. (2022). LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo. Cells, 11.","key":"ref_60","DOI":"10.3390\/cells11132090"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.18632\/oncotarget.2412","article-title":"Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway","volume":"5","author":"Park","year":"2014","journal-title":"Oncotarget"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41398-021-01570-w","article-title":"Consolidation\/reconsolidation therapies for the prevention and treatment of PTSD and re-experiencing: A systematic review and meta-analysis","volume":"11","author":"Horstmann","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.3758\/s13423-021-01978-x","article-title":"Memory consolidation as an adaptive process","volume":"28","author":"Cowan","year":"2021","journal-title":"Psychon. Bull. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11920-018-0950-7","article-title":"Memory and forgetting","volume":"20","author":"Brewin","year":"2018","journal-title":"Curr. Psychiatry Rep."},{"doi-asserted-by":"crossref","unstructured":"Jiang, Y., Shi, J., Tai, J., and Yan, L. (2024). Circadian Regulation in Diurnal Mammals: Neural Mechanisms and Implications in Translational Research. Biology, 13.","key":"ref_65","DOI":"10.3390\/biology13120958"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1113\/expphysiol.2013.072157","article-title":"Memory consolidation in humans: New evidence and opportunities","volume":"99","author":"Maguire","year":"2014","journal-title":"Exp. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neubiorev.2014.09.020","article-title":"Sleep and memory in mammals, birds and invertebrates","volume":"50","author":"Vorster","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e1698232023","DOI":"10.1523\/JNEUROSCI.1698-23.2023","article-title":"Context and Time Regulate Fear Memory Consolidation and Reconsolidation in the Basolateral Amygdala Complex","volume":"44","author":"Leake","year":"2024","journal-title":"J. Neurosci."},{"doi-asserted-by":"crossref","unstructured":"Roesler, R., Parent, M.B., LaLumiere, R.T., and McIntyre, C.K. (2021). Amygdala-hippocampal interactions in synaptic plasticity and memory formation. Neurobiol. Learn. Mem., 184.","key":"ref_69","DOI":"10.1016\/j.nlm.2021.107490"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1523\/JNEUROSCI.1944-20.2020","article-title":"Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice","volume":"41","author":"Bruzsik","year":"2021","journal-title":"J. Neurosci."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/11\/1560\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:14:59Z","timestamp":1762665299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/14\/11\/1560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":70,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["biology14111560"],"URL":"https:\/\/doi.org\/10.3390\/biology14111560","relation":{},"ISSN":["2079-7737"],"issn-type":[{"type":"electronic","value":"2079-7737"}],"subject":[],"published":{"date-parts":[[2025,11,7]]}}}