{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:51:13Z","timestamp":1792155073640,"version":"4.4.0"},"reference-count":86,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ7319"],"award-info":[{"award-number":["2024JJ7319"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2025JJ70465"],"award-info":[{"award-number":["2025JJ70465"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"doctoral research project initiation fund at Hunan University of Medicine","award":["202412"],"award-info":[{"award-number":["202412"]}]},{"name":"international Cooperative Project of Traditional Chinese Medicine","award":["2541STC72898"],"award-info":[{"award-number":["2541STC72898"]}]},{"name":"Reform Project of Hunan Provincial Education Department","award":["202401001789"],"award-info":[{"award-number":["202401001789"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>This study focuses on the plant Cyclocarya paliurus (Batal.) Iljinsk, which is unique to China and is characterized by its dual role as both a medicine food homology plant. We developed a novel framework termed \u201cintegrated quality regions\u201d, which combines ecological suitability with the spatial distribution of bioactive compounds. Our findings indicate that the distribution of C. paliurus is primarily regulated by precipitation and temperature factors. Currently, the most suitable habitats are concentrated in the provinces of Jiangxi, Zhejiang, and Hunan; however, under future climate scenarios, the centroid of suitable habitats is projected to shift northwestward. The accumulation of key bioactive compounds, specifically quercetin and kaempferol, is significantly correlated with the precipitation of warmest quarter and the aspect. Through spatial integration analysis, we identified the border region between Guangdong, Hunan, and Guangxi (centering on Yizhang County, Linwu County, and Renhua County) as a potential area for integrated quality regions, characterized by both ecological suitability and high medicinal value. Despite limitations in the sample size, the ecological\u2013chemical synergistic zoning model proposed in this study provides a scientific basis for the conservation, optimal cultivation site selection, and sustainable utilization of C. paliurus resources.<\/jats:p>","DOI":"10.3390\/biology14121639","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:33:06Z","timestamp":1763739186000},"page":"1639","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Establishment of Integrated Quality Regions for the Rare Medicine Food Homology Plant Cyclocarya paliurus (Batal.) Iljinsk in China"],"prefix":"10.3390","volume":"14","author":[{"given":"Heng","family":"Jiang","sequence":"first","affiliation":[{"name":"Sino-Pakistan International Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China"},{"name":"Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials, Guangzhou Comprehensive Experimental Station of National Industrial Technology System for Chinese Materia Medica, Guangdong Engineering Research Center of Good Agricultural Practice & Comprehensive Development for Cantonese Medicinal Materials, School of Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Sino-Pakistan International Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Wang","sequence":"additional","affiliation":[{"name":"The College of Traditional Chinese Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-7924","authenticated-orcid":false,"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Sino-Pakistan International Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-9506","authenticated-orcid":false,"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Sino-Pakistan International Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Molefe, P.F., Ghasemishahrestani, Z., Mbele, M., Khanyile, S., Farrant, J., Khumalo, N.P., and Bayat, A. 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