{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T04:32:42Z","timestamp":1769661162411,"version":"3.49.0"},"reference-count":49,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>(1) Background: Chemotherapy-induced hematological toxicity remains a major limitation to treatment continuity. Docetaxel is widely used in solid tumors due to its clinical efficacy, despite cumulative bone marrow suppression and splenic alterations. Curcuma longa is a phytochemical with antioxidant and anti-inflammatory properties that may confer cytoprotective effects on hematopoietic tissues. (2) Methods: One hundred and five male Wistar rats were randomly allocated into five treatment groups and evaluated at 7, 14, and 21 days. Animals received placebo, docetaxel alone, or docetaxel combined with Curcuma longa at doses of 25, 50, or 500 mg\/kg\/day. Post-treatment hematological parameters and relative spleen weight were analyzed using one-way ANOVA and Tukey\u2019s post hoc test. (3) Results: Docetaxel induced progressive reductions in red blood cell count, hemoglobin, hematocrit, leukocytes, and platelets, with greater severity at day 21. Curcuma longa co-treatment partially mitigated these alterations in a dose- and time-dependent manner. Intermediate doses (25\u201350 mg\/kg) showed the most consistent hematoprotective effects. High-dose treatment (500 mg\/kg) was associated with no statistically significant change in relative spleen weight. (4) Conclusions: Curcuma longa partially mitigated docetaxel-induced hematological toxicity and modulated splenic responses in this experimental model. These findings support further translational studies on chemotherapy-induced hematological toxicity to clarify the role of Curcuma longa as a low-toxicity strategy.<\/jats:p>","DOI":"10.3390\/biology15030246","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:56:12Z","timestamp":1769615772000},"page":"246","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Curcuma longa on Hematopoiesis and Splenic Mass in an Animal Model Undergoing Docetaxel Chemotherapy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-8542","authenticated-orcid":false,"given":"Isabella Morais Tavares","family":"Huber","sequence":"first","affiliation":[{"name":"Department of Graduate Studies Coordination Office (COPG), Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"},{"name":"PhD Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"},{"name":"Department of Oncology, Hematology and Transfusion, Kantonsspital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-7871","authenticated-orcid":false,"given":"Emerson Luiz Botelho","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"PhD Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"},{"name":"Candido Garcia Foundation, Umuarama 87502-210, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0600-5836","authenticated-orcid":false,"given":"Salviano Tramontin","family":"Bellettini","sequence":"additional","affiliation":[{"name":"PhD Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Donadel","sequence":"additional","affiliation":[{"name":"PhD Program in Animal Science with Emphasis on Bioactive Products, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Francisco Velasquez","family":"Matumoto","sequence":"additional","affiliation":[{"name":"Undergraduate Program in Pharmacy, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Marisa","family":"Pelloso","sequence":"additional","affiliation":[{"name":"PhD Program in Health Sciences, Universidade Estadual de Maring\u00e1 (UEM), Maring\u00e1 87020-900, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Dalva de Barros Carvalho","sequence":"additional","affiliation":[{"name":"PhD Program in Health Sciences, Universidade Estadual de Maring\u00e1 (UEM), Maring\u00e1 87020-900, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1906-1203","authenticated-orcid":false,"given":"St\u00e9fane Lele","family":"Rossoni","sequence":"additional","affiliation":[{"name":"PhD Program in Health Sciences, Universidade Estadual de Maring\u00e1 (UEM), Maring\u00e1 87020-900, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Morais Tavares","family":"Colferai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Municipal Health Authority of Apucarana, Apucarana 86800-260, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Ricardo","family":"Colferai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Municipal Health Authority of Apucarana, Apucarana 86800-260, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4906-887X","authenticated-orcid":false,"given":"Roberto Kenji Nakamura","family":"Cuman","sequence":"additional","affiliation":[{"name":"PhD Program in Health Sciences, Universidade Estadual de Maring\u00e1 (UEM), Maring\u00e1 87020-900, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Garcia","family":"Velasquez","sequence":"additional","affiliation":[{"name":"PhD Program in Phytotherapy and Medicinal Plants in Primary Health Care, Universidade Paranaense (UNIPAR), Umuarama 87502-210, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2025, April 04). 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