{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:28:31Z","timestamp":1790659711377,"version":"4.1.0"},"reference-count":118,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Foundation of Chengdu Medical College","award":["CYZYB22-15"],"award-info":[{"award-number":["CYZYB22-15"]}]},{"name":"Innovation and Entrepreneurship Training Program for College Students of Chengdu Medical College","award":["202313705023"],"award-info":[{"award-number":["202313705023"]}]},{"name":"Innovation and Entrepreneurship Training Program for College Students of Chengdu Medical College","award":["S202513705043"],"award-info":[{"award-number":["S202513705043"]}]},{"name":"Chengdu Medical College Scientific Research Organization Development Project","award":["23LHNB2YB21"],"award-info":[{"award-number":["23LHNB2YB21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Cancer is one of the leading causes of disease-related death worldwide, and targeting key regulatory genes to induce programmed cell death in tumor cells has emerged as a crucial therapeutic strategy, following surgery, radiotherapy, and chemotherapy. As a mitochondrial outer membrane protein, NIX\/BNIP3L can both mediate apoptosis to inhibit tumor cell growth and promote tumor cell survival by clearing intracellular reactive oxygen species (ROS) through mitophagy. Therefore, we summarize a brief overview of the structure and function of NIX\/BNIP3L, as well as the mechanisms of NIX\/BNIP3L generation and degradation, the role of NIX\/BNIP3L in mediating apoptosis and mitophagy and to advance the understanding of the roles of NIX\/BNIP3L in glioblastoma, lung cancer, hepatocellular carcinoma, breast cancer, pancreatic cancer, colorectal cancer and hematologic neoplasms, aiming to enhance treatment precision and improve patient outcomes.<\/jats:p>","DOI":"10.3390\/biology15040302","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:41:02Z","timestamp":1770630062000},"page":"302","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual Roles of NIX\/BNIP3L in Tumors: Friend or Foe"],"prefix":"10.3390","volume":"15","author":[{"given":"Fanghui","family":"Ge","sequence":"first","affiliation":[{"name":"Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-Origin Food, School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China"},{"name":"Experiment Teaching Demonstration Center of Laboratory Medicine, School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Clinical Medicine, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1692-3264","authenticated-orcid":false,"given":"Ziqian","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-Origin Food, School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China"},{"name":"Experiment Teaching Demonstration Center of Laboratory Medicine, School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sichuan Provincial Engineering Laboratory for Prevention and Control Technology of Veterinary Drug Residue in Animal-Origin Food, School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China"},{"name":"Experiment Teaching Demonstration Center of Laboratory Medicine, School of Laboratory Medicine, Chengdu Medical College, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4694-423X","authenticated-orcid":false,"given":"Jiandong","family":"Wang","sequence":"additional","affiliation":[{"name":"Chengdu Medical College Office of Science and Technology, Chengdu Medical College, Chengdu 610500, China"},{"name":"Key Laboratory of Nuclear and Radiation Damage Mechanisms and New Treatment Technology at Chengdu Medical College of Sichuan Province, Chengdu 610500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s12276-022-00864-3","article-title":"Molecular targeted therapy for anticancer treatment","volume":"54","author":"Min","year":"2022","journal-title":"Exp. 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