{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:46:18Z","timestamp":1770903978643,"version":"3.50.1"},"reference-count":62,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xinjiang Tianchi Talent Introduction Program","award":["2225ZZQRCXM"],"award-info":[{"award-number":["2225ZZQRCXM"]}]},{"name":"Xinjiang Dairy Industry Technology System","award":["XJARS-11-07"],"award-info":[{"award-number":["XJARS-11-07"]}]},{"name":"Technical Service Project for Wenquan Cattle Farm","award":["2523HXKT1"],"award-info":[{"award-number":["2523HXKT1"]}]},{"name":"Animal Husbandry Production Development Project of Xinjiang Uygur Autonomous Region","award":["2225XMYSC"],"award-info":[{"award-number":["2225XMYSC"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>With the continuous development of the livestock industry, the availability of high-quality roughage is becoming increasingly constrained. Therefore, the exploitation of unconventional feed resources is crucial for the sustainable development of the sector. Grape branches and leaves are a major by-product of viticulture, abundant in supply but currently underutilised. Their ensilage presents potential feed value and ecological benefits. This study aimed to systematically evaluate the effects of dietary supplementation with grape branch and leaf silage on the growth performance, serum biochemical parameters, gut microbiota, and metabolomic profiles of Kazakh rams. Sixty Kazakh rams aged 6.0 \u00b1 0.5 months with similar initial body weight (34.21 \u00b1 2.13 kg) were randomly allocated to three dietary treatment groups: the control group (CG) fed whole-crop corn silage, the EG50 group where grape branch and leaf silage replaced 50% of the whole-crop corn silage, and the EG100 group where grape branch and leaf silage entirely replaced the whole-crop corn silage. Each treatment comprised four replicates with five rams per replicate. Following a 7-day adaptation period, a formal feeding trial was conducted for 120 days, after which relevant parameters were measured. Results: (1) Compared with the CG, the dressing percentage was significantly increased in the EG100 group (p &lt; 0.05), while tail fat weight and tail fat percentage were both markedly decreased (p &lt; 0.01). (2) Serum immunoglobulin (IgA, IgG) levels and antioxidant enzyme (SOD, CAT) activities were significantly elevated in the EG100 group (p &lt; 0.05), accompanied by enhanced total antioxidant capacity. Concurrently, levels of inflammatory cytokines (IL-1\u03b2, TNF-\u03b1) and the oxidative damage marker malondialdehyde (MDA) were significantly reduced (p &lt; 0.05). (3) Based on slaughter performance, jejunal microbiota analysis was performed for the CG and EG100 groups. The relative abundance of the phylum Firmicutes increased in the EG100 group, with beneficial genera such as Ruminococcus and Lactobacillus becoming predominant. (4) Metabolomic analysis revealed significant enrichment of pathways including primary bile acid biosynthesis and glycerophospholipid metabolism in the EG100 group, with 20 key differential metabolites identified. Dietary supplementation with grape branch and leaf silage may improve slaughter performance and reduce fat deposition in Kazakh rams, potentially by modulating the gut microbiota structure and its metabolic functions, thereby synergistically enhancing nutrient utilisation, anti-inflammatory capacity, and antioxidant status. This study provides a theoretical basis for the feed-oriented and value-added utilisation of grape processing by-products. Future research should further elucidate the molecular mechanisms underlying the interaction between its active components and host metabolism.<\/jats:p>","DOI":"10.3390\/biology15040322","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:05:46Z","timestamp":1770897946000},"page":"322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Dietary Grape Branch and Leaf Silage on Growth Performance, Serum Biochemical Parameters, Gut Microbiota, and Metabolism in Kazakh Rams"],"prefix":"10.3390","volume":"15","author":[{"given":"Linhai","family":"Song","sequence":"first","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subinuer","family":"Abuduli","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadeliya","family":"Abudureyimu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buweiaizhaer","family":"Maimaitimin","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Shao","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanping","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"},{"name":"Xinjiang Key Laboratory of Meat and Milk Production Herbivore Nutrition, College of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","first-page":"110396","article-title":"A review on the sustainable energy generation from the pyrolysis of coconut biomass","volume":"137","author":"Pizarro","year":"2020","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10861","DOI":"10.1021\/jf503929v","article-title":"Vine-shoot waste aqueous extracts for re-use in agriculture obtained by different extraction techniques: Phenolic, volatile, and mineral compounds","volume":"62","author":"Zalacain","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Goufo, P., Singh, R.K., and Cortez, I. (2020). A reference list of phenolic compounds (including stilbenes) in grapevine (Vitis vinifera L.) roots, woods, canes, stems, and leaves. Antioxidants, 9.","DOI":"10.3390\/antiox9050398"},{"key":"ref_4","unstructured":"Simeonidis, K., Pastorelli, G., Pinotti, L., Ottoboni, M., and Attard, E. (2024). Chemical characterization and phenolic content of winery and grape by-products as potential feed supplement. 75th EAAP Annual Meeting, Abstract Book, European Federation of Animal Science. Available online: https:\/\/hdl.handle.net\/2434\/1096069."},{"key":"ref_5","first-page":"9","article-title":"Application progress of grape by-products in ruminant production","volume":"02","author":"Liao","year":"2024","journal-title":"Herbiv. Livest."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dallavalle, G., Secchi, G., Mancini, A., Cologna, N., Vrhovsek, U., Angeli, A., Aprea, E., Zambanini, J., Solovyev, P., and Bontempo, L. (2026). Grape stalks as a sustainable feed supplement for dairy cows: A preliminary in vivo study on milk microbiota and cheese quality. Animals, 16.","DOI":"10.3390\/ani16030388"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.anifeedsci.2017.12.004","article-title":"Effect of dietary grape pomace on growth performance, meat quality and antioxidant activity in ram lambs","volume":"236","author":"Zhao","year":"2018","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"114518","DOI":"10.1016\/j.anifeedsci.2020.114518","article-title":"Effects of high-concentrate diet supplemented with grape seed proanthocyanidins on growth performance, liver function, meat quality, and antioxidant activity in finishing lambs","volume":"266","author":"Mu","year":"2020","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Su, M., Tang, T., Tang, W., Long, Y., Wang, L., and Liu, M. (2023). Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: A research review. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1243834"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chen, F., Wang, Y., Wang, K., Chen, J., Jin, K., Peng, K., Chen, X., Liu, Z., Ouyang, J., and Wang, Y. (2023). Effects of Litsea Cubeba essential oil on growth performance, blood antioxidation, immune function, apparent digestibility of nutrients, and fecal microflora of pigs. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1166022"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106312","DOI":"10.1016\/j.compbiomed.2022.106312","article-title":"Fecal 16S rRNA sequencing and multi-compartment metabolomics revealed gut microbiota and metabolites interactions in APP\/PS1 mice","volume":"151","author":"Cheng","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"ref_12","unstructured":"(2021). Nutrient Requirements of Meat Sheep (Standard No. NY\/T 816-2021)."},{"key":"ref_13","unstructured":"AOAC International (2000). Official Methods of Analysis of AOAC International, AOAC International. [17th ed.]. Available online: https:\/\/www.aoac.org\/resources\/official-methods-of-analysis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","article-title":"Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition","volume":"74","author":"Robertson","year":"1991","journal-title":"J. Dairy Sci."},{"key":"ref_15","unstructured":"China Feed Database Center (2022). Table of Feed Composition and Nutritive Values in China (2022, 33rd Edition) (Continued). China Feed, 24, 63\u201368."},{"key":"ref_16","unstructured":"National Research Council (2007). Nutrient Requirements of Small Ruminants: Sheep, Goats, Cervids, and New World Camelids, The National Academies Press."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Abdullah, F.A.A., Borilova, G., and Steinhauserova, I. (2019). Halal Criteria Versus Conventional Slaughter Technology. Animals, 9.","DOI":"10.3390\/ani9080530"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wu, P., Fu, X., Wang, H., Guo, X., Li, X., Wang, Z., Cao, B., Li, S., Xu, Q., and Zhu, Y. (2021). Effect of silage diet (sweet sorghum vs. whole-crop corn) and breed on growth performance, carcass traits, and meat quality of lambs. Animals, 11.","DOI":"10.3390\/ani11113120"},{"key":"ref_19","unstructured":"Burtis, C.A., Ashwood, E.R., and Bruns, D.E. (2012). Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, Elsevier Saunders. [5th ed.]."},{"key":"ref_20","unstructured":"Baldwin, R.L. (1995). Modeling Ruminant Digestion and Metabolism, Chapman & Hall."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample","volume":"108","author":"Caporaso","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Innovation: Metabolomics: The apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ma, J., Li, T., Lin, L., Wang, X., Li, Z., Cao, Y., Sun, L., Hu, L., Lv, Y., and Wang, Z. (2024). Effects of grape seed extract supplementation on the growth performance, nutrients digestion and immunity of weaned lambs. Front. Vet. Sci., 11.","DOI":"10.3389\/fvets.2024.1402637"},{"key":"ref_24","first-page":"114","article-title":"Effects of grape pomace on production performance, slaughter performance and nutrient digestion and metabolism of lambs","volume":"24","author":"Lu","year":"2015","journal-title":"Acta Prataculturae Sin."},{"key":"ref_25","first-page":"37,44","article-title":"Effects of different levels of grape pomace in the diet on production performance of Kazakh sheep","volume":"45","author":"Xia","year":"2015","journal-title":"Gansu Anim. Husb. Vet."},{"key":"ref_26","first-page":"1135","article-title":"Effects of Grape Seed Proanthocyanidin Extracts on Slaughter Performance and Meat Quality of Meat Rabbit","volume":"45","author":"Wang","year":"2014","journal-title":"Acta Vet. Zootech. Sin."},{"key":"ref_27","first-page":"2755","article-title":"Effects of dietary supplementation with grape seed proanthocyanidins on growth performance, slaughter performance, meat quality and serum antioxidant indices of lambs","volume":"32","author":"Yang","year":"2020","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yao, Y., Wang, H., Lu, Z., Liu, J., Wang, Z., Li, F., and Zhang, J. (2023). Improving shelf life and content of unsaturated fatty acids in meat of lambs fed a diet supplemented with grape dregs. Foods, 12.","DOI":"10.3390\/foods12234204"},{"key":"ref_29","first-page":"55","article-title":"Effects of grape seed proanthocyanidins (GSP) on growth performance, slaughter performance and blood lipids of broilers","volume":"47","author":"Shan","year":"2024","journal-title":"Feed Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1093\/jn\/133.7.2268","article-title":"Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs","volume":"133","author":"Zern","year":"2003","journal-title":"J. Nutr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/09540105.2018.1463972","article-title":"Effects of microencapsulated probiotics and prebiotics on growth performance, antioxidative abilities, immune functions, and caecal microflora in broiler chickens","volume":"29","author":"Wang","year":"2018","journal-title":"Food Agric. Immunol."},{"key":"ref_32","first-page":"5891","article-title":"Effects of Grape Pomace with Different Processing Methods on Growth Performance, Digestion and Metabolism and Economic Benefit of Beef Cattle","volume":"34","author":"Li","year":"2022","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_33","first-page":"181","article-title":"Effect of grape vine pellet feed on the growth of beef cattle","volume":"8","author":"Li","year":"2017","journal-title":"Heilongjiang Anim. Sci. Vet. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10408398.2012.656770","article-title":"Flavonoids and immune function in human: A systematic review","volume":"55","author":"Peluso","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_35","first-page":"31","article-title":"Improvement effect of grape seed proanthocyanidin extract on periodontal inflammation in diabetic periodontitis rats and its influence on expression levels of TLR4 and NF-\u03baB in periodontal tissue","volume":"49","author":"Zhu","year":"2023","journal-title":"J. Jilin Univ. (Med. Ed.)"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hassan, F.U., Liu, C., Mehboob, M., Bilal, R.M., Arain, M.A., Siddique, F., Chen, F., Li, Y., Zhang, J., and Shi, P. (2023). Potential of dietary hemp and cannabinoids to modulate immune response to enhance health and performance in animals: Opportunities and challenges. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1285052"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2478\/aoas-2023-0011","article-title":"Meat quality, metabolic profile and antioxidant status of lambs fed on seedless grape pomace (Vitis vinifera L.)","volume":"23","author":"Steiner","year":"2023","journal-title":"Ann. Anim. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.redox.2013.12.022","article-title":"New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate","volume":"2","author":"Kim","year":"2014","journal-title":"Redox Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2014.03.018","article-title":"Effect of troxerutin on synaptic plasticity of hippocampal dentate gyrus neurons in a \u03b2-amyloid model of Alzheimer\u2018s disease: An electrophysiological study","volume":"732","author":"Babri","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_40","first-page":"21","article-title":"Effects of grape seed proanthocyanidins on growth performance, immune function and antioxidant capacity of Cherry Valley meat ducks","volume":"12","author":"Li","year":"2024","journal-title":"China Feed"},{"key":"ref_41","first-page":"59","article-title":"Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects","volume":"12","author":"Zhang","year":"2016","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1002\/imt2.198","article-title":"Duck gut metagenome reveals the microbiome signatures linked to intestinal regional, temporal development, and rearing condition","volume":"3","author":"Ma","year":"2024","journal-title":"iMeta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s10517-024-06073-4","article-title":"Alpha diversity indices as indicators of the variability of gut microbiota in obese adolescents of different ethnicities","volume":"176","author":"Klimenko","year":"2024","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_44","first-page":"8","article-title":"Research progress on rumen fiber-degrading microorganisms in ruminants","volume":"42","author":"Zhu","year":"2021","journal-title":"J. Domest. Anim. Ecol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Tardiolo, G., La Fauci, D., Riggio, V., Biondi, V., Britti, D., Licitra, F., Pino, A., Russo, N., and Chiofalo, B. (2025). Gut Microbiota of ruminants and monogastric livestock: An overview. Animals, 15.","DOI":"10.3390\/ani15050758"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.chom.2019.08.018","article-title":"The Prevotella copri complex comprises four distinct clades underrepresented in Westernized populations","volume":"26","author":"Tett","year":"2019","journal-title":"Cell Host Microbe"},{"key":"ref_47","first-page":"1050","article-title":"Changes in rumen microorganisms at different growth stages of Hulunbuir sheep and analysis of microorganisms related to mutton odor","volume":"36","author":"Zhao","year":"2024","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_48","first-page":"122","article-title":"Effects of dietary concentration:roughage ratio on rumen fermentation and flora population structure in Hu sheep","volume":"29","author":"Zhan","year":"2020","journal-title":"Acta Prataculturae Sin."},{"key":"ref_49","first-page":"2294","article-title":"Isolation, identification and fiber degradation characteristics of four rumen cellulolytic bacteria","volume":"47","author":"Wang","year":"2016","journal-title":"Chin. J. Anim. Vet. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/1745039X.2017.1283824","article-title":"Effects of Lactobacillus casei and Enterococcus faecalis on growth performance, immune function and gut microbiota of suckling piglets","volume":"71","author":"Liu","year":"2017","journal-title":"Arch. Anim. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Jin, L., Li, K., Li, Z., Huang, K., Zhang, L., Lv, J., Zhang, H., Zhang, Y., Zhang, S., and Liu, H. (2024). Investigation into critical gut microbes influencing intramuscular fat deposition in Min pigs. Animals, 14.","DOI":"10.3390\/ani14213123"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.emboj.7601049","article-title":"Endocrine functions of bile acids","volume":"25","author":"Houten","year":"2006","journal-title":"EMBO J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/nrm2330","article-title":"Membrane lipids: Where they are and how they behave","volume":"9","author":"Voelker","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nrc3162","article-title":"Choline metabolism in malignant transformation","volume":"11","author":"Glunde","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/jcb.10659","article-title":"Choline phospholipid metabolism: A target in cancer cells?","volume":"90","author":"Ackerstaff","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.semcdb.2012.03.014","article-title":"Intestinal redox biology and oxidative stress","volume":"23","author":"Circu","year":"2012","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_57","first-page":"75","article-title":"Metabolic pathways of valine and its application in pig production: A research progress","volume":"37","author":"Wei","year":"2025","journal-title":"Chin. J. Anim. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/jsfa.2577","article-title":"Unravelling the conundrum of tannins in animal nutrition and health","volume":"86","year":"2006","journal-title":"J. Sci. Food Agric."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.physiol.64.082201.154705","article-title":"Fatty acid oxidation disorders","volume":"64","author":"Rinaldo","year":"2002","journal-title":"Annu. Rev. Physiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1039\/D5FO00384A","article-title":"Exploring the lipid-lowering effects of cinnamic acid and cinnamaldehyde from the perspective of the gut microbiota and metabolites","volume":"16","author":"Wang","year":"2025","journal-title":"Food Funct."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Liu, Q., Ni, X., Chen, C., Xu, J., Pei, E., Yang, A., Xu, M., Wang, X., Fu, S., and Yu, R. (2025). Exploring the Impact of Dietary EPA\/DHA Supplementation on Lipid Metabolism of Tenebrio molitor Larvae. Insects, 16.","DOI":"10.3390\/insects16101007"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41421-025-00789-x","article-title":"A decrease in Flavonifractor plautii and its product, phytosphingosine, predisposes individuals with phlegm-dampness constitution to metabolic disorders","volume":"11","author":"Li","year":"2025","journal-title":"Cell Discov."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/4\/322\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:01:10Z","timestamp":1770901270000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/4\/322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["biology15040322"],"URL":"https:\/\/doi.org\/10.3390\/biology15040322","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}