{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T14:09:01Z","timestamp":1779458941014,"version":"3.53.1"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP23486701"],"award-info":[{"award-number":["AP23486701"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The study of genetic effects induced by low-dose alpha radiation associated with radon and its decay progeny is critically important for assessing radiation risks in regions with elevated natural background levels. The aim of this study was to evaluate the mutagenic effects (in germline cells) and teratogenic effects (in somatic tissues) of alpha radiation using the D. melanogaster model. To differentiate between these effects, teratogenic outcomes were analyzed in directly exposed individuals (phenotypic analysis of adults that developed from irradiated larvae), whereas mutagenic effects were assessed in the progeny of irradiated flies. Larvae and adult flies were exposed to calibrated alpha-particle sources with energies ranging from 4.8 to 7.7 MeV and absorbed doses of 1.90\u201344.96 mGy. The results demonstrated a statistically significant increase in the frequency of morphological abnormalities in the exposed groups, including melanotic masses and deformities of the wings, thorax, and tergites. Under 72 h exposure, a strong correlation between absorbed dose and abnormality frequency was observed (r = 0.98). In the reporter system, induction of GFP expression was detected in imaginal discs at doses above 10 mGy, indicating threshold activation of the cellular stress response. The obtained data demonstrate that chronic low-dose \u03b1-irradiation leads to an increased frequency of morphological abnormalities (indirect phenotypic manifestations of compromised genetic stability) in D. melanogaster, with the most pronounced effects observed at the level of morphogenesis. The high sensitivity of the applied test systems was confirmed, supporting the use of D. melanogaster as a bioindicator for ecogenetic monitoring of radon-prone areas, including regions of Kazakhstan.<\/jats:p>","DOI":"10.3390\/biology15100789","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T13:12:08Z","timestamp":1779455528000},"page":"789","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Alpha Particle Exposure on Genetic Stability and Morphogenesis in Drosophila melanogaster"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3223-6507","authenticated-orcid":false,"given":"Zarema","family":"Biyasheva","sequence":"first","affiliation":[{"name":"National Nanotechnology Laboratory of Open Type (NNLOT), Farabi University, Almaty 054000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6907-2382","authenticated-orcid":false,"given":"Yuliya","family":"Zaripova","sequence":"additional","affiliation":[{"name":"National Nanotechnology Laboratory of Open Type (NNLOT), Farabi University, Almaty 054000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-2415","authenticated-orcid":false,"given":"Anna","family":"Lovinskaya","sequence":"additional","affiliation":[{"name":"National Nanotechnology Laboratory of Open Type (NNLOT), Farabi University, Almaty 054000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0594-4751","authenticated-orcid":false,"given":"Vyacheslav","family":"Dyachkov","sequence":"additional","affiliation":[{"name":"Department of Nuclear Physics, Voronezh State University, Voronezh 394018, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-6647","authenticated-orcid":false,"given":"Alexandr","family":"Yushkov","sequence":"additional","affiliation":[{"name":"National Nanotechnology Laboratory of Open Type (NNLOT), Farabi University, Almaty 054000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/jnci\/djab204","article-title":"Identifying Novel Causes of Cancers to Enhance Cancer Prevention: New Strategies Are Needed","volume":"114","author":"Brennan","year":"2022","journal-title":"J. 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