{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:02:15Z","timestamp":1785402135211,"version":"3.56.0"},"reference-count":215,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Jilin Province Science and Technology Department","doi-asserted-by":"crossref","award":["NO.20210204035YY"],"award-info":[{"award-number":["NO.20210204035YY"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"crossref"}]},{"award":["NO.20210204035YY"],"award-info":[{"award-number":["NO.20210204035YY"]}],"id":[{"id":"https:\/\/ror.org\/049x38272","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation, playing a critical role in the pathogenesis of various cardiomyopathies, including hypertrophic, dilated, diabetic, ischemic, doxorubicin-induced, and septic cardiomyopathy, as well as myocardial ischemia\u2013reperfusion injury. This article provides a comprehensive narrative review of the molecular mechanisms of ferroptosis\u2014centered on dysregulation of the GPX4\/System Xc\u2212 axis, iron metabolism, and lipid metabolism\u2014and its role in cardiovascular diseases, with a specific focus on the cardioprotective effects of Traditional Chinese Medicine (TCM). Through a systematic analysis of recent literature, we highlight active components (e.g., baicalin, ginsenoside Rg3, resveratrol, tanshinone IIA), compound formulations (e.g., Qishen Granule, Zhilong Huoxue Tongyu Capsule), and electroacupuncture therapy, which exert effects via multi-target regulation of ferroptosis-related pathways such as Nrf2\/HO-1\/GPX4, p53\/SLC7A11, and PI3K\/AKT. Evidence indicates that TCM interventions effectively alleviate cardiomyocyte ferroptosis by activating the Nrf2 antioxidant pathway to upregulate GPX4\/SLC7A11, modulating iron metabolism to reduce labile iron pools, and inhibiting ACSL4\/ALOX15-mediated lipid peroxidation, with these effects validated in diverse cardiovascular disease models showing improved cardiac function. Targeting ferroptosis offers a novel therapeutic strategy for cardiovascular diseases, and TCM\u2014with its synergistic multi-component, multi-target, multi-pathway advantages\u2014holds significant potential in this context. Future research should prioritize elucidating complex network mechanisms and advancing clinical translation via high-quality studies to provide new theoretical foundations and drug candidates for cardiovascular disease management.<\/jats:p>","DOI":"10.3390\/biology15110824","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:33:54Z","timestamp":1779687234000},"page":"824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress on the Role of Traditional Chinese Medicine in Regulating Ferroptosis in Cardiovascular Diseases"],"prefix":"10.3390","volume":"15","author":[{"given":"Pan","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Meng","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Chang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ling","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yang","family":"Xu","sequence":"additional","affiliation":[{"name":"Innovation Practice Center, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Yu","sequence":"additional","affiliation":[{"name":"Innovation and Entrepreneurship College, Changchun University of Chinese Medicine, Jilin 130117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1161\/01.CIR.93.5.841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies","volume":"93","author":"Richardson","year":"1996","journal-title":"Circulation"},{"key":"ref_2","first-page":"640","article-title":"Cardiomyopathy: An Overview","volume":"96","author":"Brieler","year":"2017","journal-title":"Am. 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