{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:58:02Z","timestamp":1793379482484,"version":"4.5.0"},"reference-count":122,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Brain aging is a complex biological process characterised by progressive neuronal and synaptic decline, in which disruption of mitochondrial quality control plays a central role. This system encompasses multiple synergistic components, including mitochondrial biogenesis, dynamic equilibrium, autophagic clearance, and energy metabolism. Aging induces dysfunction across these processes, precipitating mitochondrial fragmentation, functional decline, and energy crises, ultimately driving cognitive deterioration. Exercise is a promising non-pharmacological intervention for preserving brain health during aging, and its benefits may be mediated, at least in part, through modulation of mitochondrial quality control. Specifically, exercise has been shown to activate key signaling pathways such as AMPK\/SIRT1\/PGC-1\u03b1, thereby promoting mitochondrial biogenesis and metabolic adaptation. It may also regulate mitochondrial dynamics and mitophagy via pathways including cAMP\/PKA\/Drp1 and AMPK\/mTOR. In addition, emerging evidence indicates that exercise may influence brain mitochondrial function through activity-dependent regulation of mitochondrial gene expression and systemic signaling factors. Furthermore, this review discusses potential differences between exercise modalities and highlights future directions for personalised intervention strategies, providing a theoretical basis for the application of exercise in delaying brain aging and preventing neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/biology15110854","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T01:08:02Z","timestamp":1780535282000},"page":"854","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mechanisms by Which Exercise Delays Brain Aging Through Regulation of the Mitochondrial Quality Control System"],"prefix":"10.3390","volume":"15","author":[{"given":"Xinyi","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3088-4740","authenticated-orcid":false,"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahong","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6128-5847","authenticated-orcid":false,"given":"Yingjie","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5539-8779","authenticated-orcid":false,"given":"Qiguan","family":"Jin","sequence":"additional","affiliation":[{"name":"College of Physical Education, Yangzhou University, Yangzhou 225000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e661","DOI":"10.1016\/S2468-2667(20)30185-7","article-title":"Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: A cross-sectional study","volume":"5","author":"Jia","year":"2020","journal-title":"Lancet Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cger.2013.07.002","article-title":"Normal cognitive aging","volume":"29","author":"Harada","year":"2013","journal-title":"Clin. Geriatr. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2022.02.021","article-title":"The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function","volume":"182","author":"Zhao","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_5","first-page":"2674","article-title":"Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?","volume":"16","author":"Zuo","year":"2025","journal-title":"Aging Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/jnc.14037","article-title":"Brain aging and neurodegeneration: From a mitochondrial point of view","volume":"143","author":"Grimm","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_7","first-page":"402","article-title":"Physical exercise, cognition, and brain health in aging","volume":"47","author":"Barha","year":"2024","journal-title":"Trends Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1249\/JES.0000000000000242","article-title":"Novel Strategies for Healthy Brain Aging","volume":"49","author":"Wahl","year":"2021","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1113\/JP278853","article-title":"Exercise and mitochondrial health","volume":"599","author":"Memme","year":"2021","journal-title":"J. Physiol.-Lond."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1152\/japplphysiol.00611.2022","article-title":"Exercise and mitochondrial remodeling to prevent age-related neurodegeneration","volume":"134","author":"Miller","year":"2023","journal-title":"J. Appl. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neurol.2020.03.017","article-title":"Normal ageing of the brain: Histological and biological aspects","volume":"176","author":"Teissier","year":"2020","journal-title":"Rev. Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41380-018-0098-1","article-title":"Brain age and other bodily \u2018ages\u2019: Implications for neuropsychiatry","volume":"24","author":"Cole","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41591-024-03144-x","article-title":"Brain aging patterns in a large and diverse cohort of 49,482 individuals","volume":"30","author":"Yang","year":"2024","journal-title":"Nat. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e52677","DOI":"10.7554\/eLife.52677","article-title":"Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associations","volume":"9","author":"Smith","year":"2020","journal-title":"eLife"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e2318153","DOI":"10.1001\/jamanetworkopen.2023.18153","article-title":"Characterization of Brain Volume Changes in Aging Individuals With Normal Cognition Using Serial Magnetic Resonance Imaging","volume":"6","author":"Fujita","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-neuro-072116-031357","article-title":"Mechanisms of Hippocampal Aging and the Potential for Rejuvenation","volume":"40","author":"Fan","year":"2017","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.tins.2010.09.003","article-title":"When neurogenesis encounters aging and disease","volume":"33","author":"Lazarov","year":"2010","journal-title":"Trends Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neurobiolaging.2022.08.007","article-title":"Age-related ultrastructural changes in the lateral cortex of the inferior colliculus","volume":"120","author":"Mafi","year":"2022","journal-title":"Neurobiol. Aging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular Senescence: Defining a Path Forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102141","DOI":"10.1016\/j.arr.2023.102141","article-title":"Cellular senescence in brain aging and neurodegeneration","volume":"93","author":"Eggen","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lepore, G., Succu, S., Cappai, M.G., Frau, A., Senes, A., Zedda, M., Farina, V., and Gadau, S.D. (2024). Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates. Animals, 14.","DOI":"10.20944\/preprints202408.1405.v1"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"eadp6547","DOI":"10.1126\/science.adp6547","article-title":"Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice","volume":"386","author":"Li","year":"2024","journal-title":"Science"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s43587-024-00753-6","article-title":"Plasma proteomics identify biomarkers and undulating changes of brain aging","volume":"5","author":"Liu","year":"2025","journal-title":"Nat. Aging"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: A new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0057-6","article-title":"Decipher reliable biomarkers of brain aging by integrating literature-based evidence with interactome data","volume":"50","author":"Bae","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.neurobiolaging.2012.11.024","article-title":"Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer\u2019s disease","volume":"34","author":"Berchtold","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"fcae150","DOI":"10.1093\/braincomms\/fcae150","article-title":"Magnetoencephalography-derived oscillatory microstate patterns across lifespan: The Cambridge centre for ageing and neuroscience cohort","volume":"6","author":"Huang","year":"2024","journal-title":"Brain Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature08983","article-title":"Neural mechanisms of ageing and cognitive decline","volume":"464","author":"Bishop","year":"2010","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Canto","year":"2009","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s12035-015-9299-7","article-title":"Overexpression of PGC-1alpha Influences Mitochondrial Signal Transduction of Dopaminergic Neurons","volume":"53","author":"Ye","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e70657","DOI":"10.1111\/cns.70657","article-title":"AMPK\/SIRT1\/PGC-1\u03b1 Signaling Pathway: Molecular Mechanisms and Targeted Strategies From Energy Homeostasis Regulation to Disease Therapy","volume":"31","author":"Chen","year":"2025","journal-title":"CNS Neurosci. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1007\/s11064-023-03934-8","article-title":"The Role of PGC-1\u03b1-Mediated Mitochondrial Biogenesis in Neurons","volume":"48","author":"Chen","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41419-022-05542-w","article-title":"SIRT6 is a key regulator of mitochondrial function in the brain","volume":"14","author":"Smirnov","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.3390\/cimb46080522","article-title":"The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function","volume":"46","author":"Patyal","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s11357-012-9465-z","article-title":"Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding","volume":"35","author":"Picca","year":"2013","journal-title":"Age"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Scatena, R., Bottoni, P., and Giardina, B. (2012). Mitochondria and Aging. Advances in Mitochondrial Medicine, Springer.","DOI":"10.1007\/978-94-007-2869-1"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1093\/nar\/gkaa804","article-title":"Mechanisms of replication and repair in mitochondrial DNA deletion formation","volume":"48","author":"Fontana","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Cardanho-Ramos, C., and Morais, V.A. (2021). Mitochondrial Biogenesis in Neurons: How and Where. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222313059"},{"key":"ref_39","first-page":"9372182","article-title":"Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development","volume":"2019","author":"Manda","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1007\/s11357-025-01629-2","article-title":"Cardiac-specific overexpression of serum response factor regulates age-associated decline in mitochondrial function","volume":"47","author":"Patyal","year":"2025","journal-title":"Geroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E2523\u20132532","DOI":"10.1073\/pnas.1208141109","article-title":"Serum Response Factor (SRF)-cofilin-actin signaling axis modulates mitochondrial dynamics","volume":"109","author":"Beck","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Grel, H., Woznica, D., Ratajczak, K., Kalwarczyk, E., Anchimowicz, J., Switlik, W., Olejnik, P., Zielonka, P., Stobiecka, M., and Jakiela, S. (2023). Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713033"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-018-0211-2","article-title":"Structural basis of mitochondrial receptor binding and constriction by DRP1","volume":"558","author":"Kalia","year":"2018","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: Mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.devcel.2022.03.019","article-title":"Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage","volume":"57","author":"Cao","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.molcel.2018.11.034","article-title":"The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging","volume":"73","author":"Mottis","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Rosa, F.L.L., de Souza, I.I.A., Monnerat, G., Campos de Carvalho, A.C., and Maciel, L. (2023). Aging Triggers Mitochondrial Dysfunction in Mice. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310591"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Dong, W., Cheng, S., Huang, F., Fan, W., Chen, Y., Shi, H., and He, H. (2011). Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging. Med. Sci. Monit., 17.","DOI":"10.12659\/MSM.881706"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Araujo, A.P.B., Vargas, G., Hayashide, L.S., Matias, I., Andrade, C.B.V., de Carvalho, J.J., Gomes, F.C.A., and Diniz, L.P. (2024). Aging promotes an increase in mitochondrial fragmentation in astrocytes. Front. Cell. Neurosci., 18.","DOI":"10.3389\/fncel.2024.1496163"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1038\/s41467-018-07416-2","article-title":"MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size","volume":"9","author":"Lewis","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8894","DOI":"10.1038\/s41598-018-26962-9","article-title":"PQQ ameliorates D-galactose induced cognitive impairments by reducing glutamate neurotoxicity via the GSK-3beta\/Akt signaling pathway in mouse","volume":"8","author":"Zhou","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1039\/C9FO02453K","article-title":"Carnosine ameliorates age-related dementia via improving mitochondrial dysfunction in SAMP8 mice","volume":"11","author":"Dai","year":"2020","journal-title":"Food Funct."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.expneurol.2009.08.014","article-title":"Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging","volume":"220","author":"Head","year":"2009","journal-title":"Exp. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1083\/jcb.201507022","article-title":"Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria","volume":"212","author":"Korwitz","year":"2016","journal-title":"J. Cell Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molmed.2019.07.002","article-title":"Mitophagy and Neuroprotection","volume":"26","author":"Lou","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Zhang, Y.H., Weng, J.J., Huan, L.Y., Sheng, S., and Xu, F.Q. (2023). Mitophagy in atherosclerosis: From mechanism to therapy. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1165507"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10863-017-9727-7","article-title":"From autophagy to mitophagy: The roles of P62 in neurodegenerative diseases","volume":"49","author":"Liu","year":"2017","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.molcel.2015.10.009","article-title":"Measuring In Vivo Mitophagy","volume":"60","author":"Sun","year":"2015","journal-title":"Mol. Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cub.2018.12.021","article-title":"Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline","volume":"29","author":"Glatigny","year":"2019","journal-title":"Curr. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbr.2017.07.003","article-title":"The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits","volume":"334","author":"Yu","year":"2017","journal-title":"Behav. Brain Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"167470","DOI":"10.1016\/j.bbadis.2024.167470","article-title":"Accumulation of damaged mitochondria in aging astrocytes due to mitophagy dysfunction: Implications for susceptibility to mitochondrial stress","volume":"1870","author":"Diniz","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3892\/ijmm.2016.2827","article-title":"PINK1 signaling in mitochondrial homeostasis and in aging (Review)","volume":"39","author":"Kitagishi","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Kasai, S., Shimizu, S., Tatara, Y., Mimura, J., and Itoh, K. (2020). Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology. Biomolecules, 10.","DOI":"10.3390\/biom10020320"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e017820","DOI":"10.1161\/JAHA.120.017820","article-title":"Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature","volume":"9","author":"Tyrrell","year":"2020","journal-title":"Am. Hear. Assoc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41419-017-0105-5","article-title":"Mitochondria-associated membranes in aging and senescence: Structure, function, and dynamics","volume":"9","author":"Janikiewicz","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1474-4422(10)70277-5","article-title":"Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer\u2019s disease","volume":"10","author":"Kapogiannis","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1089\/ars.2012.4774","article-title":"Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration","volume":"20","author":"Yin","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s42255-023-00838-3","article-title":"Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions","volume":"5","author":"Tai","year":"2023","journal-title":"Nat. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Schiliro, C., and Firestein, B.L. (2021). Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation. Cells, 10.","DOI":"10.3390\/cells10051056"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/jcbfm.2013.196","article-title":"Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer\u2019s disease: A 13C NMR study","volume":"34","author":"Sancheti","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"103815","DOI":"10.1016\/j.ebiom.2022.103815","article-title":"Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review","volume":"76","author":"Tortajada","year":"2022","journal-title":"EBioMedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13024-021-00495-8","article-title":"Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer\u2019s disease brain","volume":"16","author":"Klein","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-2990.2012.01285.x","article-title":"Mitochondrial function in human brains is affected by pre- and post mortem factors","volume":"39","author":"Harish","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13020-023-00755-3","article-title":"Bushen-Yizhi formula ameliorates mitochondrial dysfunction and oxidative stress via AMPK\/Sirt1 signaling pathway in D-gal-induced aging rats","volume":"18","author":"Liao","year":"2023","journal-title":"Chin. Med."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Xu, Y., Xue, M., Li, J., Ma, Y., Wang, Y., Zhang, H., and Liang, H. (2024). Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis. Nutrients, 16.","DOI":"10.3390\/nu16101512"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Torres, A.K., Jara, C., Llanquinao, J., Lira, M., Cortes-Diaz, D., and Tapia-Rojas, C. (2023). Mitochondrial Bioenergetics, Redox Balance, and Calcium Homeostasis Dysfunction with Defective Ultrastructure and Quality Control in the Hippocampus of Aged Female C57BL\/6J Mice. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065476"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s42003-025-08152-2","article-title":"Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons","volume":"8","author":"Varghese","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"15164","DOI":"10.1007\/s12035-025-05121-y","article-title":"Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders","volume":"62","author":"Tu","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12017-018-8500-3","article-title":"Exercise Training Protects Against Aging-Induced Cognitive Dysfunction via Activation of the Hippocampal PGC-1alpha\/FNDC5\/BDNF Pathway","volume":"20","author":"Belviranli","year":"2018","journal-title":"Neuromolecular. Med."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.neurobiolaging.2014.05.033","article-title":"Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation","volume":"35","author":"E","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.vh.2016.10.004","article-title":"BDNF and Hippocampal Synaptic Plasticity","volume":"104","author":"Leal","year":"2017","journal-title":"Vitam. Horm."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1alpha\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12974-022-02483-1","article-title":"Prehabilitative resistance exercise reduces neuroinflammation and improves mitochondrial health in aged mice with perioperative neurocognitive disorders","volume":"19","author":"Liu","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s11332-025-01353-6","article-title":"Short-term swimming induces the enhancement of mitochondrial-, survival-, and proliferation-related proteins in the hippocampus of healthy aged mice without affecting behavior","volume":"21","author":"Cruz","year":"2025","journal-title":"Sport Sci. Health"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00221-023-06749-9","article-title":"Effects of exercise-targeted hippocampal PDE-4 methylation on synaptic plasticity and spatial learning\/memory impairments in D-galactose-induced aging rats","volume":"242","author":"Jin","year":"2024","journal-title":"Exp. Brain Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1096\/fj.201901747RR","article-title":"p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence","volume":"34","author":"Kim","year":"2020","journal-title":"FASEB J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbrc.2017.05.041","article-title":"Shaping mitochondrial dynamics: The role of cAMP signalling","volume":"500","author":"Gerbino","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1007\/s11064-024-04164-2","article-title":"Aerobic Exercise Ameliorates Cognitive Disorder and Declined Oxidative Stress via Modulating the Nrf2 Signaling Pathway in D-galactose Induced Aging Mouse Model","volume":"49","author":"Xie","year":"2024","journal-title":"Neurochem. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.celrep.2014.08.006","article-title":"AMPK modulates tissue and organismal aging in a non-cell-autonomous manner","volume":"8","author":"Ulgherait","year":"2014","journal-title":"Cell Rep."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/acel.12524","article-title":"Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways","volume":"16","author":"Lesniewski","year":"2017","journal-title":"Aging Cell"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Oddo, S., Lanza, M., Casili, G., and Caccamo, A. (2025). The Role of S6K1 in Aging and Alzheimer\u2019s Disease: Mechanistic Insights and Therapeutic Potential. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26135923"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"112226","DOI":"10.1016\/j.exger.2023.112226","article-title":"Alleviation of ischemic brain injury by exercise preconditioning is associated with modulation of autophagy and mitochondrial dynamics in cerebral cortex of female aged mice","volume":"178","author":"Qin","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.fshw.2022.03.028","article-title":"Trehalose ameliorates autophagy dysregulation in aged cortex and acts as an exercise mimetic to delay brain aging in elderly mice","volume":"11","author":"Pan","year":"2022","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/gerona\/glw242","article-title":"Lysosomal Proteolysis Is Associated With Exercise-Induced Improvement of Mitochondrial Quality Control in Aged Hippocampus","volume":"72","author":"Luo","year":"2017","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"110647","DOI":"10.1016\/j.exger.2019.110647","article-title":"The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise","volume":"124","author":"Liu","year":"2019","journal-title":"Exp. Gerontol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e24421","DOI":"10.1016\/j.heliyon.2024.e24421","article-title":"The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice","volume":"10","author":"Lei","year":"2024","journal-title":"Heliyon"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1042\/BST20120260","article-title":"Metabolic triad in brain aging: Mitochondria, insulin\/IGF-1 signalling and JNK signalling","volume":"41","author":"Yin","year":"2013","journal-title":"Biochem. Soc. Trans."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Lee, J.M., Sim, T.H., Kim, S.H., Choi, Y.J., Lee, J.H., Yeo, S.G., and Kim, Y.J. (2025). Exercise-Induced FNDC5\/Irisin Ameliorates Cognitive Impairment in Aged Mice, Associated with Antioxidant and Neurotrophic Responses. Antioxidants, 14.","DOI":"10.3390\/antiox14101239"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1093\/gerona\/gly072","article-title":"Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT1, SIRT3, and VEGF in the Substantia Nigra","volume":"73","author":"Munoz","year":"2018","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"6852","DOI":"10.18632\/aging.103046","article-title":"Swimming exercise stimulates IGF1\/ PI3K\/Akt and AMPK\/SIRT1\/PGC1alpha survival signaling to suppress apoptosis and inflammation in aging hippocampus","volume":"12","author":"Lin","year":"2020","journal-title":"Aging"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/nutrit\/nuaa091","article-title":"Brain foods\u2014The role of diet in brain performance and health","volume":"79","author":"Ekstrand","year":"2021","journal-title":"Nutr. Rev."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1249\/JES.0000000000000349","article-title":"Aerobic Exercise Training for the Aging Brain: Effective Dosing and Vascular Mechanism","volume":"53","author":"Tarumi","year":"2025","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4103\/1673-5374.182709","article-title":"Moderate exercise prevents neurodegeneration in D-galactose-induced aging mice","volume":"11","author":"Li","year":"2016","journal-title":"Neural Regen. Res."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Gujral, S., Cameron, J.L., Conaty, K., Ziady, S., Sahu, A., Jakicic, J.M., Rogers, R.J., Rosano, C., Vallejo, A.N., and Erickson, K.I. (2024). Intermittent low-intensity and moderate-intensity exercise effects on cognition in community-dwelling older adults: A pilot study exploring biological mechanisms. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1432909"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1113\/JP286923","article-title":"Acute exercise alters brain glucose metabolism in aging and Alzheimer\u2019s disease","volume":"604","author":"Green","year":"2026","journal-title":"J. Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"e70590","DOI":"10.1002\/mco2.70590","article-title":"Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro-Glial Protection Against Cerebral Ischemia","volume":"7","author":"Inaba","year":"2026","journal-title":"MedComm"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"H772","DOI":"10.1152\/ajpheart.00625.2023","article-title":"Cerebrovascular adaptations to habitual resistance exercise with aging","volume":"326","author":"Allison","year":"2024","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10522-021-09929-8","article-title":"Exercise renovates H2S and Nrf2-related antioxidant pathways to suppress apoptosis in the natural ageing process of male rat cortex","volume":"22","author":"Lin","year":"2021","journal-title":"Biogerontology"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Tan, J., Krasilshchikov, O., Kuan, G., Hashim, H.A., Aldhahi, M.I., Al-Mhanna, S.B., and Badicu, G. (2023). The Effects of Combining Aerobic and Heavy Resistance Training on Body Composition, Muscle Hypertrophy, and Exercise Satisfaction in Physically Active Adults. Healthcare, 11.","DOI":"10.3390\/healthcare11172443"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/jgs.12611","article-title":"Effect of tai chi on cognitive performance in older adults: Systematic review and meta-analysis","volume":"62","author":"Wayne","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2015.06.012","article-title":"Mind-body therapies and control of inflammatory biology: A descriptive review","volume":"51","author":"Bower","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.psyneuen.2017.08.008","article-title":"Yoga, mindfulness-based stress reduction and stress-related physiological measures: A meta-analysis","volume":"86","author":"Pascoe","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/PSY.0000000000000414","article-title":"Mitochondrial Nexus to Allostatic Load Biomarkers","volume":"79","author":"Picard","year":"2017","journal-title":"Psychosom. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.brainresrev.2007.02.006","article-title":"Hippocampal formation: Shedding light on the influence of sex and stress on the brain","volume":"55","author":"McEwen","year":"2007","journal-title":"Brain Res. Rev."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.tins.2020.04.010","article-title":"Effects of Exercise on Brain and Cognition Across Age Groups and Health States","volume":"43","author":"Stillman","year":"2020","journal-title":"Trends Neurosci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40798-021-00344-4","article-title":"High-Intensity Interval Training in Older Adults: A Scoping Review","volume":"7","author":"Marriott","year":"2021","journal-title":"Sports Med. Open"},{"key":"ref_118","first-page":"655","article-title":"Variability in Individual Response to Aerobic Exercise Interventions Among Older Adults","volume":"26","author":"Whipple","year":"2018","journal-title":"J. Aging Phys. Act."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1249\/MSS.0b013e318213fefb","article-title":"American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise","volume":"43","author":"Garber","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/bjsports-2016-096587","article-title":"Exercise interventions for cognitive function in adults older than 50: A systematic review with meta-analysis","volume":"52","author":"Northey","year":"2018","journal-title":"Br. J. Sports Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jacc.2015.11.034","article-title":"Exercise at the Extremes: The Amount of Exercise to Reduce Cardiovascular Events","volume":"67","author":"Eijsvogels","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13063-024-08696-4","article-title":"The effect of the APOE4 genotype on physiological and cognitive health in randomised controlled trials with an exercise intervention: A systematic review and meta-analysis","volume":"26","author":"Spencer","year":"2025","journal-title":"Trials"}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/11\/854\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:16:54Z","timestamp":1780633014000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/11\/854"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":122,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["biology15110854"],"URL":"https:\/\/doi.org\/10.3390\/biology15110854","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]}}}