{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:43:35Z","timestamp":1782823415109,"version":"3.54.5"},"reference-count":54,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>(1) Background: Ovulatory dysfunction (OD) is frequently the first clinical expression of an underlying polyendocrine or metabolic disturbance. In the context of the international consensus renaming polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS), our primary aim was to estimate the prevalence of four OD-associated endocrinopathies\u2014hyperandrogenemia, insulin resistance (IR), thyroid dysfunction, and hyperprolactinemia\u2014in a Chilean symptomatic clinical cohort, and to compare their frequencies between adolescents and young adults. (2) Methods: Cross-sectional study including 251 women (\u22652 years post-menarche) with confirmed OD, stratified into Group A (12\u201318 years; n = 96) and Group B (19\u201335 years; n = 155). (3) Results: Hyperandrogenemia was the most prevalent endocrinopathy in both groups (50.0% vs. 49.0%; p = 0.882), driven primarily by elevated dehydroepiandrosterone sulfate (DHEAS) in Group A (37.5% vs. 24.5%; p = 0.028). IR was significantly more frequent in adolescents (55.2% vs. 41.3%; p = 0.032). Thyroid dysfunction (primary threshold: thyroid-stimulating hormone [TSH] &gt; 5.0 \u03bcIU\/mL) was present in 2.1% and 5.2% of Groups A and B (p = 0.226). Hyperprolactinemia (&gt;25 ng\/mL; macroprolactin-excluded) was detected in 13.5% and 13.6% (p = 0.999). (4) Conclusions: All four endocrinopathies were detectable during adolescence, with prevalences largely comparable to those observed in young adult women, supporting the rationale for considering structured polyendocrine evaluation in women with OD \u2265 2 years post-menarche within the PAInT (Prolactin, Androgens, Insulin, and Thyroid hormones) framework.<\/jats:p>","DOI":"10.3390\/biology15131041","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:01:17Z","timestamp":1782813677000},"page":"1041","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyendocrine\u2013Metabolic Profile in Adolescents and Young Women with Ovulatory Dysfunction: A Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Juan Pablo","family":"Del R\u00edo","sequence":"first","affiliation":[{"name":"Departamento de Psiquiatr\u00eda y Salud Mental, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6255-6712","authenticated-orcid":false,"given":"Hugo","family":"Soto","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Institute (RHRI), Santiago 8330078, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-1677","authenticated-orcid":false,"given":"Patricio","family":"Contreras","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Institute (RHRI), Santiago 8330078, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8182-6135","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Becerra","sequence":"additional","affiliation":[{"name":"Escuela de Fonoaudiolog\u00eda y Departamento de Ciencias Qu\u00edmicas y Biol\u00f3gicas, Universidad Bernardo O\u2019Higgins, Santiago 8370993, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2043-0170","authenticated-orcid":false,"given":"Camila","family":"Contreras-Rojo","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Institute (RHRI), Santiago 8330078, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-7147","authenticated-orcid":false,"given":"Manuel E.","family":"Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Investigaci\u00f3n, Universidad Bernardo O\u2019Higgins, Santiago 8370993, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Vigil","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Institute (RHRI), Santiago 8330078, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/00243639.2017.1394053","article-title":"Ovulation, a sign of health","volume":"84","author":"Vigil","year":"2017","journal-title":"Linacre Q."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/humrep\/del478","article-title":"Can we achieve international agreement on terminologies and definitions used to describe abnormalities of menstrual bleeding?","volume":"22","author":"Fraser","year":"2007","journal-title":"Hum. 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