{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:17:49Z","timestamp":1783523869954,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Vitamin B6 is a coenzyme involved in more than 150 biochemical reactions in the body. Its intake has favorable effects for many diseases like Parkinson\u2019s disease, glaucoma, and endometriosis. Vitamin B6 can be obtained from tablets, aqua vitamin, and a variety of food sources, including meat, fish, and vegetables. There is a need for process analytical control for fast, ultrasensitive, and selective methods of determination of vitamin B6 in order to produce drugs of high pharmaceutical purity. Also, the on-site determination of vitamin B6 in vegetables can contribute to the fast, real-time control of the quality of vegetables. Therefore, a fast ultrasensitive sensing strip based on the immobilization of heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin on a matrix containing single-walled carbon nanotubes was constructed and used for on-site pharmaceutical process control of vitamin B6, as well as for on-site quality control of food. The sensing strip provided two linear concentration ranges: the first one between 1.69 \u00d7 10\u221215 and 1.69 \u00d7 10\u22125 g mL\u22121 with a sensitivity of 6.96 \u00d7 104 s\u22121 g\u22121 mL, and the second one between 1.69 \u00d7 10\u22125 and 1.69 \u00d7 10\u22123 g mL\u22121 with a sensitivity of 3.65 \u00d7 102 s\u22121 g\u22121 mL. The limit of quantification was 1.69 fg mL\u22121. A % recovery higher than 94.50% was determined for Vitamin B6 in tablets, aqua vitamin, and avocado, with % relative standard deviations lower than 1.00%. A lower determination limit was obtained when the sensing strip was used for the assay of vitamin B6 in different samples compared with other methods used to date for its assay. Also, the results of the analysis were obtained faster, in real time, compared with other methods for which a long sample processing time is needed before analysis.<\/jats:p>","DOI":"10.3390\/biology15141098","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T14:27:23Z","timestamp":1783520843000},"page":"1098","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fast Ultrasensitive Sensing Strip for the Electrochemical Determination of Vitamin B6"],"prefix":"10.3390","volume":"15","author":[{"given":"Erg\u00fcn Yukmel","family":"Rasit","sequence":"first","affiliation":[{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-2483","authenticated-orcid":false,"given":"Raluca-Ioana","family":"Stefan-van Staden","sequence":"additional","affiliation":[{"name":"Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, 011061 Bucharest, Romania"},{"name":"Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-2177","authenticated-orcid":false,"given":"Damaris-Cristina","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Laboratory of Electrochemistry and PATLAB, National Institute of Research for Electrochemistry and Condensed Matter, 060021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stach, K., Stach, W., and Augoff, K. 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