{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:19:13Z","timestamp":1785421153521,"version":"3.56.0"},"reference-count":103,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-33\/2026-03\/200007"],"award-info":[{"award-number":["451-03-33\/2026-03\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovations of the Republic of Serbia","award":["451-03-66\/2024-03\/200042"],"award-info":[{"award-number":["451-03-66\/2024-03\/200042"]}]},{"award":["451-03-33\/2026-03\/200007"],"award-info":[{"award-number":["451-03-33\/2026-03\/200007"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"publisher"}]},{"award":["451-03-66\/2024-03\/200042"],"award-info":[{"award-number":["451-03-66\/2024-03\/200042"]}],"id":[{"id":"https:\/\/ror.org\/01znas443","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Background: Antibiotic-associated gut dysbiosis affects lung health and contributes to disease progression, but the individual response to antibiotics, which leads to host-specific reactions to the same respiratory insult, is not fully understood. Methods: Before infection with Aspergillus fumigatus, Albino Oxford (AO) and Dark Agouti (DA) rats received a mixture of antibiotics with poor systemic absorption to induce microbial perturbation only in the gut, and lung and gut tissue and colonic contents were analyzed. Results: Treatment with antibiotics induced gut inflammation in both rat strains, which was more pronounced in AO rats, and a disturbance in lung immunity was observed only in DA rats. Antibiotic-associated gut microbiota disturbance revealed rat strain-specific bacterial profiles (increased Gammaproteobacteria in DA and decreased Coriobacteriia in AO rats). Although gut dysbiosis increased the risk of lung A. fumigatus infection in both rat strains, a higher fungal burden was detected in the lungs of AO rats, whereas lymph node cell activation and lung tissue inflammation were observed in DA rats. Conclusions: Rat strain differences in response to antibiotic- and\/or infection-induced gut dysbiosis suggest that basal gut microbiota may influence the lung immune response during A. fumigatus disease, highlighting the importance of the interplay of genotype-specific host gut microbial community with the environmental constraints in shaping individual immune makeup.<\/jats:p>","DOI":"10.3390\/biology15141132","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T07:28:27Z","timestamp":1783927707000},"page":"1132","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Basal Gut Microbiota Profiles Are Associated with Strain-Specific Lung Responses to Aspergillus fumigatus"],"prefix":"10.3390","volume":"15","author":[{"given":"Dusanka","family":"Popovic","sequence":"first","affiliation":[{"name":"Immunotoxicology Group, Department of Ecology, Institute for Biological Research \u201cSinisa Stankovic\u201d\u2014National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Mirkov","sequence":"additional","affiliation":[{"name":"Immunotoxicology Group, Department of Ecology, Institute for Biological Research \u201cSinisa Stankovic\u201d\u2014National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Tucovic","sequence":"additional","affiliation":[{"name":"Immunotoxicology Group, Department of Ecology, Institute for Biological Research \u201cSinisa Stankovic\u201d\u2014National Institute of the Republic of Serbia, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-7481","authenticated-orcid":false,"given":"Aleksandra 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