{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:05:36Z","timestamp":1784790336161,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Development Plan Project of Jilin Province","award":["YDZJ202501ZYTS805"],"award-info":[{"award-number":["YDZJ202501ZYTS805"]}]},{"name":"Science and Technology Research Project of the Jilin Provincial Department of Education","award":["JJKH20250832KJ"],"award-info":[{"award-number":["JJKH20250832KJ"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Lead (Pb) pollution is a global public health issue, yet the mechanisms underlying Pb-induced kidney aging remain poorly understood. Selenium (Se), an essential trace element critical for kidney health, primarily exerts its physiological roles via selenoproteins; among them, membrane-bound selenoproteins strategically localized at the endoplasmic reticulum and plasma membrane, have emerged as potential molecular links in Se-mediated protection. In this study, Hyline chicken models (treated with 350.00 mg\/L Pb or\/and 1.00 mg\/kg Se) and HK-2 cell models (treated with 200 \u03bcM Pb or\/and 2.5 \u03bcM Se) were established to investigate the protective mechanism of Se to Pb poisoning in kidneys, with emphasis on membrane-bound selenoproteins and kidney aging. Results showed that Pb significantly decreased (p &lt; 0.05) membrane-bound selenoproteins and induced kidney aging. Inflammation and autophagy were involved, as Pb significantly increased (p &lt; 0.05) pro-inflammatory cytokines interleukin-4 (IL-4) and interleukin-12\u03b2 (IL-12\u03b2), and autophagy-related genes autophagy related 5 (ATG5), BCL2 interacting coiled coil protein 1 (Beclin 1), and microtubule-associated protein 1A\/1B-light chain 3 (LC3-II) while significantly suppressing (p &lt; 0.05) interleukin-2 (IL-2) and mammalian target of rapamycin (mTOR). Se had a relieving effect on it, as evidenced by significantly reversing (p &lt; 0.05) the changes in the above indicators. Interestingly, Selenoprotein T (SELENOT), as a hub membrane-bound selenoprotein, is sensitive to Pb poisoning (Pb exposure decreased SELENOT mRNA expression to 56%, 34%, and 19% of the control levels at 30, 60, and 90 days, respectively). Knockdown of SELENOT aggravated Pb-induced inflammation, autophagy, and cellular senescence, meaning that SELENOT protected against kidney aging via suppressing inflammation and autophagy under Pb stress. These findings establish membrane-bound selenoproteins as essential molecular hubs that orchestrate inflammation resolution and autophagy in Se\u2019s antagonism against Pb-induced kidney aging, highlighting promising therapeutic targets for nephropathy.<\/jats:p>","DOI":"10.3390\/biology15151218","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:11:42Z","timestamp":1784787102000},"page":"1218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SELENOT, a Key Membrane-Bound Selenoprotein, Mediates Selenium\u2019s Protection Against Lead-Induced Renal Aging in Chickens by Modulating Inflammation and Autophagy"],"prefix":"10.3390","volume":"15","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"School of Public Health, Beihua University, Jilin 132013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Qiu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghang","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumei","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Yantai University, Yantai 264005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Heilongjiang Animal Husbandry Service, Harbin 150069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0912-3325","authenticated-orcid":false,"given":"Xiaohua","family":"Teng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Tang","sequence":"additional","affiliation":[{"name":"Electrical and Information Engineering College, Jilin Agricultural Science and Technology University, Jilin 132101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20844","DOI":"10.1007\/s11356-025-36792-8","article-title":"Biological approaches to mitigate heavy metal pollution from battery production effluents: Advances, challenges, and perspectives","volume":"32","author":"Cavali","year":"2025","journal-title":"Environ. 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