{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:43:56Z","timestamp":1786164236732,"version":"build-2736575974"},"reference-count":48,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"crossref","award":["V311"],"award-info":[{"award-number":["V311"]}],"id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"crossref","award":["SV003"],"award-info":[{"award-number":["SV003"]}],"id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003947","name":"Universidad Nacional de La Plata","doi-asserted-by":"crossref","award":["V102"],"award-info":[{"award-number":["V102"]}],"id":[{"id":"10.13039\/501100003947","id-type":"DOI","asserted-by":"crossref"}]},{"award":["V311"],"award-info":[{"award-number":["V311"]}],"id":[{"id":"https:\/\/ror.org\/01tjs6929","id-type":"ROR","asserted-by":"publisher"}]},{"award":["SV003"],"award-info":[{"award-number":["SV003"]}],"id":[{"id":"https:\/\/ror.org\/01tjs6929","id-type":"ROR","asserted-by":"publisher"}]},{"award":["V102"],"award-info":[{"award-number":["V102"]}],"id":[{"id":"https:\/\/ror.org\/01tjs6929","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Soft tissue sarcomas are malignant neoplasms originating from mesenchymal cells. In cats, there are two groups: inoculation site-associated sarcomas (ISSs) and non-inoculation site-associated sarcomas (NISSs). The aim of this study was to investigate the immunoexpression of metalloproteinases (MMPs) 2 and 9, tissue inhibitors (TIMPs) 1 and 2, and the main molecules related to angiogenesis and vascular count in both sarcoma groups; compare their expression; and evaluate their association with angiogenesis. Both tumor groups expressed all the molecules evaluated. A positive correlation was detected between MMP-2 and angiogenic factors in both ISSs and NISSs. MMP-9 expression correlated positively with MMP-2 in both groups. TIMP-1 correlated with both MMP and with angiogenic factors in ISS. Fibroblast growth factor receptor 2 (FGFR-2) expression was higher in NISS. Studying the pathways that regulate angiogenesis in these neoplasms is crucial for identifying ways to intervene and limit neoplastic progression, thereby developing new therapeutic approaches.<\/jats:p>","DOI":"10.3390\/biology15151322","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T08:08:02Z","timestamp":1786003682000},"page":"1322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microenvironment of Sarcomas Associated and Not Associated with Inoculation Sites in Domestic Cats: The Role of Metalloproteinases and Angiogenic Factors"],"prefix":"10.3390","volume":"15","author":[{"given":"Carolina","family":"Wright","sequence":"first","affiliation":[{"name":"Instituto de Morfolog\u00eda y Patolog\u00eda Animal (IMPA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejo Carlos","family":"Scarano","sequence":"additional","affiliation":[{"name":"Instituto de Morfolog\u00eda y Patolog\u00eda Animal (IMPA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4314-906X","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Verdes","sequence":"additional","affiliation":[{"name":"Departamento de Patobiolog\u00eda de la Facultad de Veterinaria, Universidad de la Rep\u00fablica Uruguay, Montevideo  13000, Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana Graciela","family":"Scenna","sequence":"additional","affiliation":[{"name":"Instituto de Morfolog\u00eda y Patolog\u00eda Animal (IMPA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Graciela","family":"Duchene","sequence":"additional","affiliation":[{"name":"Independent Researcher, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Osacar","sequence":"additional","affiliation":[{"name":"Independent Researcher, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Mart\u00edn","family":"Di Pierro","sequence":"additional","affiliation":[{"name":"Independent Researcher, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8277-9155","authenticated-orcid":false,"given":"Paula","family":"Risso","sequence":"additional","affiliation":[{"name":"C\u00e1tedra Bioestad\u00edstica, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Badura","sequence":"additional","affiliation":[{"name":"Laboratorio de Patolog\u00eda de Aves y Pil\u00edferos, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9459-138X","authenticated-orcid":false,"given":"Claudio Gustavo","family":"Barbeito","sequence":"additional","affiliation":[{"name":"Instituto de Morfolog\u00eda y Patolog\u00eda Animal (IMPA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9657-3978","authenticated-orcid":false,"given":"Francisco","family":"Acu\u00f1a","sequence":"additional","affiliation":[{"name":"Instituto de Morfolog\u00eda y Patolog\u00eda Animal (IMPA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Andrea","family":"Santelices Iglesias","sequence":"additional","affiliation":[{"name":"Instituto de Morfolog\u00eda y Patolog\u00eda Animal (IMPA), Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata 1900, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1096-2867(98)80029-7","article-title":"Principles of treatment for soft tissue sarcoma","volume":"13","author":"Dernell","year":"1998","journal-title":"Clin. Tech. Small Anim. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/1098612X20942393","article-title":"Prognostic factors and proposed grading system for cutaneous and subcutaneous soft tissue sarcomas in cats, based on a retrospective study","volume":"23","author":"Dobromylskyj","year":"2021","journal-title":"J. Feline Med. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Dobromylskyj, M.J. (2022). Feline soft tissue sarcomas: A review of the classification and histological grading, with comparison to human and canine. Animals, 12.","DOI":"10.3390\/ani12202736"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Soto, S., Blatter, S., Hobi, S., Steck, M., Lechmann, J., R\u00fcfenacht, S., K\u00fchn, N., Ruetten, M., Ignatenko, N., and Krudewig, C. (2024). Feline facial spindle cell tumors in 29 cats: Histomorphological and immunohistochemical characterization. Animals, 14.","DOI":"10.3390\/ani14071103"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.54203\/scil.2025.wvj23","article-title":"Soft Tissue Sarcomas in Cats: A Comparative Review on Injection-Site and Non-Injection-Site Sarcomas","volume":"15","author":"Wright","year":"2025","journal-title":"World Vet. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1515\/pjvs-2015-0041","article-title":"Epidemiological and morphological analysis of feline injection site sarcomas","volume":"18","author":"Kliczkowska","year":"2015","journal-title":"Pol. J. Vet. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1098612X221098961","article-title":"Non-injection-site soft tissue sarcoma in cats: Outcome following adjuvant radiotherapy","volume":"24","author":"Zajc","year":"2022","journal-title":"J. Feline Med. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wojtkowska, A., Ma\u0142ek, A., Gizi\u0144ski, S., Sapierzy\u0144ski, R., Rodo, A., Soko\u0142owska, J., Zabielska-Koczyw\u0105s, K.A., Wojtalewicz, A., Walewska, M., and Kautz, E. (2024). Comparison of MMP-2, MMP-9, COX-2, and PGP expression in feline injection-site and feline noninjection-site sarcomas\u2014Pilot study. Animals, 14.","DOI":"10.3390\/ani14142110"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1556\/avet.56.2008.1.11","article-title":"Feline vaccine-associated fibrosarcoma induced by aluminium compound in two cats: Short communication","volume":"56","author":"Deim","year":"2008","journal-title":"Acta Vet. Hung."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/03009858211012949","article-title":"Targeting peritumoral lesions identified by computed tomography and magnetic resonance imaging in feline injection-site sarcomas for microscopic examination","volume":"58","author":"Terry","year":"2021","journal-title":"Vet. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rigoglio, N.N., Rabelo, A.C.S., Borghesi, J., De S\u00e1 Schiavo, M.G., Fratini, P., Prazeres, P.H.D.M., Mc Manus Pimentel, C.M., Birbrair, A., and Miglino, M.A. (2020). The Tumor Microenvironment: Focus on Extracellular Matrix. Tumor Microenvironment: Extracellular Matrix Components\u2013Part A, Springer International Publishing.","DOI":"10.1007\/978-3-030-40146-7_1"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Jana, S., Chatterjee, K., Ray, A.K., DasMahapatra, P., and Swarnakar, S. (2016). Regulation of matrix metalloproteinase-2 activity by COX-2-PGE2-pAKT axis promotes angiogenesis in endometmetalloproteinase. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0163540"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.2147\/OTT.S99580","article-title":"Evaluation of MMP-9 and MMP-2 and their suppressor TIMP-1 and TIMP-2 in adenocarcinoma of esophagogastric junction","volume":"9","author":"Lu","year":"2016","journal-title":"OncoTargets Ther."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/0300985816677148","article-title":"Feline injection-site sarcoma: Matrix remodeling and prognosis","volume":"54","author":"Porcellato","year":"2017","journal-title":"Vet. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1939-1676.2002.tb01614.x","article-title":"Matrix metalloproteinase activity in tumor, stromal tissue, and serum from cats with malignancies","volume":"16","author":"Jankowski","year":"2002","journal-title":"J. Vet. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1515\/BC.2003.097","article-title":"Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases","volume":"384","author":"Bode","year":"2003","journal-title":"Biol. Chem."},{"key":"ref_17","unstructured":"Coronato, S., Laguens, G., and Di Girolamo, V. (2012). Rol de las metaloproteinasas y sus inhibidores en patolog\u00eda tumoral. Medicina, 72."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ajpath.2011.09.008","article-title":"An alternate perspective on the roles of TIMPs and MMPs in pathology","volume":"180","author":"Moore","year":"2012","journal-title":"Am. J. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/carcin\/bgac037","article-title":"Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancer","volume":"43","author":"Peeney","year":"2022","journal-title":"Carcinogenesis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jcpa.2017.07.004","article-title":"Immunohistochemical expression profiles of cell adhesion molecules, matrix metalloproteinases and their tissue inhibitors in central and peripheral neoplastic foci of feline mammary carcinoma","volume":"157","author":"Pisamai","year":"2017","journal-title":"J. Comp. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2460\/ajvr.2004.65.373","article-title":"Expression of matrix metalloproteinases in feline vaccine site-associated sarcomas","volume":"65","author":"Sorensen","year":"2004","journal-title":"Am. J. Vet. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00109-008-0337-z","article-title":"Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathways","volume":"86","author":"Cao","year":"2008","journal-title":"J. Mol. Med."},{"key":"ref_23","first-page":"5391","article-title":"Postvaccinal sarcomas in the cat: Epidemiology and electron probe microanalytical identification of aluminum","volume":"52","author":"Hendrick","year":"1992","journal-title":"Cancer Res."},{"key":"ref_24","first-page":"83","article-title":"Angiog\u00e9nesis: VEGF\/VEGFRs como blancos terap\u00e9uticos en el tratamiento contra el c\u00e1ncer [Angiogenesis: VEGF\/VEGFRs as therapeutic targets in cancer treatment]","volume":"1","author":"Herrera","year":"2006","journal-title":"Cancerolog\u00eda"},{"key":"ref_25","first-page":"100422","article-title":"Tumor angiogenesis: Current challenges and therapeutic opportunities","volume":"28","author":"Salah","year":"2021","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_26","first-page":"1","article-title":"Correlaci\u00f3n de la expresi\u00f3n del receptor 2 del factor de crecimiento de fibroblastos, del receptor \u03b1 del factor de crecimiento derivado de plaquetas y de la ciclooxigenasa-2 con la proliferaci\u00f3n de c\u00e9lulas neopl\u00e1sicas y la vascularizaci\u00f3n en sarcomas felinos asociados a sitios de inoculaci\u00f3n","volume":"25","author":"Zanuzzi","year":"2023","journal-title":"Investig. Vet."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40364-025-00779-x","article-title":"Decoding tumor angiogenesis: Pathways, mechanisms, and future directions in anti-cancer strategies","volume":"13","author":"Liu","year":"2025","journal-title":"Biomark. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"175586","DOI":"10.1016\/j.ejphar.2023.175586","article-title":"The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF","volume":"949","author":"Ghalehbandi","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_30","first-page":"309","article-title":"Microvessel density and VEGF\/VEGF receptor status and their role in sarcomas of the pulmonary artery","volume":"19","author":"Gaumann","year":"2008","journal-title":"Oncol. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Patruno, R., Passantino, G., Laface, C., Tinelli, A., Zito, A., Ruggieri, R., Luposella, F., Gadaleta, P., Laforgia, M., and Lacitignola, L. (2020). Microvascular density, Endothelial area, and Ki-67 proliferative index correlate each other in cat post-injection fibrosarcoma. Cells, 10.","DOI":"10.3390\/cells10010031"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.rmed.2019.08.003","article-title":"VEGF and FGF-2: Promising targets for the treatment of respiratory disorders","volume":"156","author":"Laddha","year":"2019","journal-title":"Respir. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3390\/ph3030572","article-title":"Platelet-derived growth factor (PDGF)\/PDGF receptors (PDGFR) axis as target for antitumor and antiangiogenic therapy","volume":"3","author":"Raica","year":"2010","journal-title":"Pharmaceuticals"},{"key":"ref_34","first-page":"1","article-title":"Dise\u00f1os de muestreo (II)","volume":"12","author":"Robledo","year":"2005","journal-title":"Nure Investig."},{"key":"ref_35","unstructured":"Santelices Iglesias, O.A. (2019). Caracterizaci\u00f3n de Sarcomas Felinos en Sitios de Inoculaci\u00f3n Vacunal en la Rep\u00fablica Argentina. [Doctoral Dissertation, Universidad Nacional de La Plata]."},{"key":"ref_36","unstructured":"Gomez Castro, M.G. (2025). Caracterizaci\u00f3n del Componente Vascular y Estudio de la Angiog\u00e9nesis en la Placenta de la Gata. [Doctoral Dissertation, Universidad Nacional de La Plata]."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-7961-5-2","article-title":"Assessment of allergen cross-reactivity","volume":"5","author":"Aalberse","year":"2007","journal-title":"Clin. Mol. Allergy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1600676","DOI":"10.1002\/mnfr.201600676","article-title":"Bioinformatic screening and detection of allergen cross-reactive IgE-binding epitopes","volume":"61","author":"McClain","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"110578","DOI":"10.1016\/j.vetimm.2023.110578","article-title":"Cross-reactivity of human monoclonal antibodies with canine peripheral blood mononuclear cells","volume":"259","author":"Ciftci","year":"2023","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/sysbio\/syx055","article-title":"Multivariate phylogenetic comparative methods: Evaluations, comparisons, and recommendations","volume":"67","author":"Adams","year":"2018","journal-title":"Syst. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1582-4934.2005.tb00355.x","article-title":"Matrix metalloproteinases and angiog\u00e9nesis","volume":"9","author":"Rundhaug","year":"2005","journal-title":"J. Cell. Mol. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4055\/cios.2014.6.4.443","article-title":"Role of matrix metalloproteinase (MMP) 2 and MMP-9 in soft tissue sarcoma","volume":"6","author":"Yang","year":"2014","journal-title":"Clin. Orthop. Surg."},{"key":"ref_44","first-page":"5865","article-title":"The relationship between MMP-2 and MMP-9 expression levels with breast cancer incidence and prognosis","volume":"14","author":"Li","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"L60","DOI":"10.1152\/ajplung.00104.2024","article-title":"PDGFR\u03b1-positive cell-derived TIMP-1 modulates adaptive immune responses to influenza A viral infection","volume":"328","author":"Dutta","year":"2025","journal-title":"Am. J. Physiol.-Lung Cell. Mol. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115267","DOI":"10.1016\/j.ejca.2025.115267","article-title":"The role of IL-8 in cancer development and its impact on immunotherapy resistance","volume":"218","author":"Meier","year":"2025","journal-title":"Eur. J. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.tips.2025.09.004","article-title":"Next-generation isoform-selective fibroblast growth factor receptor inhibitors","volume":"46","author":"Chen","year":"2025","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.annonc.2026.01.004","article-title":"Mechanisms of Clinical Resistance to Selective FGFR2 Inhibition by Lirafugratinib","volume":"37","author":"Ellis","year":"2026","journal-title":"Ann. Oncol."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/15\/1322\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T04:19:21Z","timestamp":1786162761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/15\/1322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":48,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["biology15151322"],"URL":"https:\/\/doi.org\/10.3390\/biology15151322","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}