{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T09:28:44Z","timestamp":1786354124558,"version":"build-2736575974"},"reference-count":201,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"College Students\u2019 Innovation and Entrepreneurship Training Program","award":["X2026161"],"award-info":[{"award-number":["X2026161"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The neural circuits of the human brain are highly complex (due to the number of neurons and the diversity of synaptic connections), hindering the analysis of the pathological mechanisms of neurodegenerative diseases. Invertebrates with simple yet well-differentiated nervous systems have a natural advantage over mammalian model organisms in the identification of pathogenic genes and functional studies of neurodegenerative diseases. They can provide unique and profound insights into the pathogenesis of complex human neurodegenerative diseases and the formulation of intervention strategies. This article reviews the conserved mechanisms of three neurodegenerative diseases across species, including protein homeostasis imbalance and aggregation toxicity, mitochondrial dysfunction and metabolic abnormalities, axonal transport defects, and loss of synaptic function. Based on research on three invertebrates in the field of neurodegeneration, namely Caenorhabditis elegans (C. elegans), Drosophila melanogaster (D. melanogaster), and Bombyx mori (B. mori), we cover three major types of neurodegenerative diseases: Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and Huntington\u2019s disease (HD). The aim is to find important inspirations for the future prevention and treatment of neurodegenerative diseases from the aspects of the material basis and existing treatment strategies.<\/jats:p>","DOI":"10.3390\/biology15161351","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:08:53Z","timestamp":1786349333000},"page":"1351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revealing the Mechanisms of Alzheimer\u2019s, Parkinson\u2019s and Huntington\u2019s Diseases Through Invertebrate Models"],"prefix":"10.3390","volume":"15","author":[{"given":"Xing","family":"Ding","sequence":"first","affiliation":[{"name":"College of Life Sciences, Neijiang Normal University, Neijiang 641100, China"},{"name":"Key Laboratory of Regional Characteristic Agricultural Resources, Department of Education, Si-Chuan 641100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400715, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limin","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Neijiang Normal University, Neijiang 641100, China"},{"name":"Key Laboratory of Regional Characteristic Agricultural Resources, Department of Education, Si-Chuan 641100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxia","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Neijiang Normal University, Neijiang 641100, China"},{"name":"Key Laboratory of Regional Characteristic Agricultural Resources, Department of Education, Si-Chuan 641100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","unstructured":"UN\/Department of Economic and Social Affairs (2022). 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