{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T05:26:27Z","timestamp":1786771587871,"version":"build-2736575974"},"reference-count":60,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2022YFC2601303"],"award-info":[{"award-number":["2022YFC2601303"]}]},{"name":"Military Project","award":["CHJ24C025"],"award-info":[{"award-number":["CHJ24C025"]}]},{"name":"Marine Science and Technology Project of Jiangsu Marine Resources Development Technology Innovation Center","award":["LWKJ-13"],"award-info":[{"award-number":["LWKJ-13"]}]},{"name":"National Key Research and Development Plan of China","award":["2019YFC0312604"],"award-info":[{"award-number":["2019YFC0312604"]}]},{"name":"Shanghai Agriculture Science and Technology Innovation Project","award":["2017, No 1-13"],"award-info":[{"award-number":["2017, No 1-13"]}]},{"name":"Shanghai Science and Technology Commission Innovation Project","award":["16391903500"],"award-info":[{"award-number":["16391903500"]}]},{"name":"Shanghai Science and Technology Commission Innovation Project","award":["17391902200"],"award-info":[{"award-number":["17391902200"]}]},{"name":"National Marine 863 Project","award":["2014AA093506"],"award-info":[{"award-number":["2014AA093506"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>Skin photoaging is primarily induced by ultraviolet (UV) radiation and is accompanied by extracellular matrix (ECM) degradation, abnormal pigmentation, and loss of skin elasticity. Excessive melanin synthesis represents a key cause of pigmentary skin disorders. Natural polyphenols with dual skin-whitening and anti-photoaging activities have attracted increasing attention as cosmetic ingredients. This study examined the effects of polyphenol-enriched fraction from the brown alga Sargassum fusiforme (SFP). Zebrafish embryos and human melanoma A375 cells were used to evaluate the depigmenting efficacy of SFP, while UVA-induced human dermal fibroblasts (HDFs) were employed to assess its anti-photoaging activity. SFP significantly decreased melanin levels in both models in a dose-dependent and reversible manner by suppressing tyrosinase activity. In terms of anti-photoaging effects, SFP markedly suppressed UVA-induced matrix metalloproteinases (MMPs) expression and elevated key ECM components, including type I collagen, elastin, and hyaluronic acid. In conclusion, SFP exerts dual beneficial effects by attenuating melanogenesis via tyrosinase inhibition and alleviating photoaging damage by suppressing MMPs to protect ECM. These results provide a scientific foundation for the use of SFP as a dual-purpose natural cosmetic ingredient with significant potential in the cosmetics sector.<\/jats:p>","DOI":"10.3390\/biology15161388","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:47:11Z","timestamp":1786625231000},"page":"1388","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Anti-Melanogenesis and Anti-Photoaging Effects of Sargassum fusiforme Polyphenols Based on Zebrafish and Cell Models"],"prefix":"10.3390","volume":"15","author":[{"given":"Jiamin","family":"Lu","sequence":"first","affiliation":[{"name":"College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jahwa United Co., Ltd., Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuner","family":"Cai","sequence":"additional","affiliation":[{"name":"College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3704-7905","authenticated-orcid":false,"given":"Peimin","family":"He","sequence":"additional","affiliation":[{"name":"College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghui","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9308-0147","authenticated-orcid":false,"given":"Ya","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Jahwa United Co., Ltd., Shanghai 200082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai 201306, China"},{"name":"Marine Biomedical Science and Technology Innovation Platform of Lingang Special Area, Shanghai 201306, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/pca.1264","article-title":"Phenolic Composition and Antioxidant Properties of Some Traditionally Used Medicinal Plants Affected by the Extraction Time and Hydrolysis","volume":"22","author":"Komes","year":"2011","journal-title":"Phytochem. 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