{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:16:09Z","timestamp":1788066969978,"version":"build-2784847793"},"reference-count":256,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005074","name":"Kuwait Institute for Scientific Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005074","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/041tgg678","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology"],"abstract":"<jats:p>The plant Artemisia scoparia, of the Artemisia genus in the Asteraceae family, is known for its broad range of medicinal applications. Recent research on the traditional applications, phytochemistry, and potential biological activity of the plant is summarized in this review. Anticancer, antioxidant, antimicrobial, anti-inflammatory, neuroprotective, and hepatoprotective properties of this plant are well known. The complex bioactive profile of the plant has been revealed by analysis of key chemical elements such as coumarins, flavonoids, phenolic acids, chromones, and essential oils. Research gaps show the necessity of toxicity analyses, clinical trials, and further bioactivity assays, to confirm the therapeutic potential of A. scoparia. The review also covers the morphology, distribution, traditional uses, and how this plant has adapted to desert ecosystems. This plant has the potential to be used in land restoration, herbicide, and associated plants in commercial agriculture. The present review provides an in-depth understanding of the chemical composition and promising biological activities of A. scoparia. These bioactivities draw attention to develop novel drugs. However, further research is needed to examine the toxicity and clinical effectiveness of this plant. Although not yet studied in poultry nutrition, A. scoparia shows potential as a natural feed additive based on evidence from other Artemisia species. Finally, the future research directions to deepen our understanding of this plant to confirm its clinical applications and use in poultry feed are also provided.<\/jats:p>","DOI":"10.3390\/biology15171466","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:27:46Z","timestamp":1787920066000},"page":"1466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unlocking the Potential of Artemisia scoparia: Current Evidence and Research Gaps"],"prefix":"10.3390","volume":"15","author":[{"given":"Tahani","family":"Al-Surrayai","sequence":"first","affiliation":[{"name":"Food Security Program, Environment and Life Sciences Research Center, Kuwait Institute for Scientific Research, P.O. Box 24885, Kuwait City 13109, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-562X","authenticated-orcid":false,"given":"Hanan","family":"Al-Khalaifah","sequence":"additional","affiliation":[{"name":"Food Security Program, Environment and Life Sciences Research Center, Kuwait Institute for Scientific Research, P.O. Box 24885, Kuwait City 13109, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0865-1993","authenticated-orcid":false,"given":"Sheikh","family":"Shreaz","sequence":"additional","affiliation":[{"name":"Food Security Program, Environment and Life Sciences Research Center, Kuwait Institute for Scientific Research, P.O. Box 24885, Kuwait City 13109, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113960","DOI":"10.1016\/j.jep.2021.113960","article-title":"Artemisia scoparia: Traditional Uses, Active Constituents and Pharmacological Effects","volume":"273","author":"Ding","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Boudreau, A., Richard, A.J., Harvey, I., and Stephens, J.M. (2022). Artemisia scoparia and Metabolic Health: Untapped Potential of an Ancient Remedy for Modern Use. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.727061"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e202400414","DOI":"10.1002\/cbdv.202400414","article-title":"Chemical Composition of Artemisia scoparia and Their Bioactivities","volume":"21","author":"Kuerban","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5628601","DOI":"10.1155\/2022\/5628601","article-title":"Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles","volume":"2022","author":"Semwal","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4791","DOI":"10.1038\/s41598-024-55128-z","article-title":"Bioprospecting of Artemisia Genus: From Artemisinin to Other Potentially Bioactive Compounds","volume":"14","author":"Negri","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.foodchem.2008.09.101","article-title":"Chemical Composition and Antioxidant Activity of Essential Oil from Residues of Artemisia scoparia","volume":"114","author":"Singh","year":"2009","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1055\/s-2005-837790","article-title":"Chemical Composition and Antimicrobial Activity of the Essential Oils of Artemisia scoparia and A. capillaris","volume":"71","author":"Cha","year":"2005","journal-title":"Planta Medica"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1226-8615(08)60318-0","article-title":"Chemical Composition and Insecticidal Activity of Artemisia scoparia Essential Oil against Three Coleopteran Stored-Product Insects","volume":"9","author":"Negahban","year":"2006","journal-title":"J. Asia-Pac. Entomol."},{"key":"ref_9","first-page":"66","article-title":"Molecular Phylogeny and Evolution of Floral Characters of Artemisia and Allies (Anthemideae, Asteraceae): Evidence from nrDNA ETS and ITS Sequences","volume":"57","author":"Sanz","year":"2008","journal-title":"Taxon"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Septembre-Malaterre, A., Lalarizo Rakoto, M., Marodon, C., Bedoui, Y., Nakab, J., Simon, E., Hoarau, L., Savriama, S., Strasberg, D., and Guiraud, P. (2020). Artemisia annua, a Traditional Plant Brought to Light. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21144986"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.17348\/era.7.0.147-162","article-title":"Ethnobotany of the Genus Artemisia L. (Asteraceae) in Pakistan","volume":"7","author":"Hayat","year":"2009","journal-title":"Ethnobot. Res. Appl."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2012.10.022","article-title":"Evaluation of Anti-Nociceptive, Anti-Inflammatory and Antipyretic Activities of Artemisia scoparia Hydromethanolic Extract","volume":"145","author":"Habib","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.3390\/molecules17032542","article-title":"The Artemisia L. Genus: A Review of Bioactive Essential Oils","volume":"17","author":"Abad","year":"2012","journal-title":"Molecules"},{"key":"ref_14","unstructured":"(2026, May 13). USDA-ARS Germplasm Resources Information Network (GRIN), Available online: https:\/\/www.ars-grin.gov."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/14786419.2016.1207071","article-title":"The Genus Artemisia L. in the Northern Region of Saudi Arabia: Essential Oil Variability and Antibacterial Activities","volume":"31","author":"Guetat","year":"2017","journal-title":"Nat. Prod. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.15666\/aeer\/2203_28212833","article-title":"Biodiversity of Artemisia Species from Saudi Arabia Based on Morphological and Molecular Markers","volume":"22","author":"Alqahtani","year":"2024","journal-title":"Appl. Ecol. Environ. Res."},{"key":"ref_17","unstructured":"Abdullah, M.T., and Al-Dosari, M.E. (2022). Vegetation of the State of Kuwait, Environmental Public."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0012-8252(00)00005-2","article-title":"An Overview of the Surface and Near-Surface Geology, Geomorphology and Natural Resources of Kuwait","volume":"50","author":"Mukhopadhyay","year":"2000","journal-title":"Earth-Sci. Rev."},{"key":"ref_19","unstructured":"(2026, May 12). Artemisia annua Waldst. & Kit.|Plants of the World Online|Kew Science. Available online: https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:180092-1."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Parveen, A., Abbas, M.G., Keefover-Ring, K., Binyameen, M., Moz\u016braitis, R., and Azeem, M. (2024). Chemical Composition of Essential Oils from Natural Populations of Artemisia scoparia Collected at Different Altitudes: Antibacterial, Mosquito Repellent, and Larvicidal Effects. Molecules, 29.","DOI":"10.3390\/molecules29061359"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Yang, L., Wen, K.-S., Ruan, X., Zhao, Y.-X., Wei, F., and Wang, Q. (2018). Response of Plant Secondary Metabolites to Environmental Factors. Molecules, 23.","DOI":"10.3390\/molecules23040762"},{"key":"ref_22","first-page":"65","article-title":"Response of growth and metabolism of Artemisia scoparia to precipitation change in desert steppe","volume":"44","author":"Chen","year":"2022","journal-title":"J. Beijing For. Univ."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1134\/S1068162016070189","article-title":"Composition of Essential Oil of Artemisia scoparia Waldst. et Kit. from Buryatia and Mongolia","volume":"42","author":"Zhigzhitzhapova","year":"2016","journal-title":"Russ. J. Bioorganic Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.sajb.2008.11.001","article-title":"Artemisia afra: A Potential Flagship for African Medicinal Plants?","volume":"75","author":"Liu","year":"2009","journal-title":"S. Afr. J. Bot."},{"key":"ref_25","first-page":"1","article-title":"Pharmacology, Taxonomy and Phytochemistry of the Genus Artemisia Specifically from Pakistan: A Comprehensive Review","volume":"4","author":"Zeb","year":"2019","journal-title":"Pharm. Biomed. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.17521\/cjpe.2018.0211","article-title":"Reproductive Characteristics of Artemisia scoparia and the Analysis of the Underlying Soil Drivers in a Desert Steppe of China","volume":"43","author":"Chen","year":"2019","journal-title":"Chin. J. Plant Ecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/00087114.2015.1109924","article-title":"Resource Allocation in Relation to Meiotic System in Two Species of Artemisia from North-West Himalayas","volume":"68","author":"Sharma","year":"2015","journal-title":"Caryologia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s40009-014-0233-8","article-title":"Sex-Expression and Reproductive Output in Three Species of Artemisia L. Abounding Jammu Province (J&K), India","volume":"37","author":"Sharma","year":"2014","journal-title":"Natl. Acad. Sci. Lett."},{"key":"ref_29","first-page":"2914","article-title":"Adaptability of foliar morphological, anatomical and physiolgical characteristics of pioneer species Artemisia scoparia on Hilly-gully Loess region at different slope sites","volume":"36","author":"Huadong","year":"2016","journal-title":"Acta Ecol. Sin."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1186\/s40064-016-2678-3","article-title":"Artemisia Dominant Species Succession Relating to the Soil Moisture Decrease in Abandoned Land of the Loess Plateau (China): Comparative Study of Drought-Adaptive Characteristics","volume":"5","author":"Wang","year":"2016","journal-title":"SpringerPlus"},{"key":"ref_31","first-page":"4535","article-title":"Effect of drought on leaf Anatomical characteristics of four Artemisia species in the loess plateau","volume":"34","author":"Wang","year":"2014","journal-title":"Acta Ecol. Sin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/10412905.2007.9699294","article-title":"Phenological Variation of the Essential Oil of Artemisia scoparia Waldst. et Kit from Iran","volume":"19","author":"Mirjalili","year":"2007","journal-title":"J. Essent. Oil Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Fu, X., Liu, H., Hassani, D., Peng, B., Yan, X., Wang, Y., Wang, C., Li, L., Liu, P., and Pan, Q. (2020). AaABCG40 Enhances Artemisinin Content and Modulates Drought Tolerance in Artemisia annua. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.00950"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liu, H., Wang, Q., Wang, J., Liu, Y., Renzeng, W., Zhao, G., and Niu, K. (2022). Key Factors for Differential Drought Tolerance in Two Contrasting Wild Materials of Artemisia Wellbyi Identified Using Comparative Transcriptomics. BMC Plant Biol., 22.","DOI":"10.1186\/s12870-022-03830-3"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Zhang, X.-Y., Sun, X.-Z., Zhang, S., Yang, J.-H., Liu, F.-F., and Fan, J. (2019). Comprehensive Transcriptome Analysis of Grafting onto Artemisia scoparia W. to Affect the Aphid Resistance of Chrysanthemum (Chrysanthemum morifolium T.). BMC Genom., 20.","DOI":"10.1186\/s12864-019-6158-3"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"309808","DOI":"10.1155\/2013\/309808","article-title":"Morphological, Physiological, and Structural Responses of Two Species of Artemisia to NaCl Stress","volume":"2013","author":"Guan","year":"2013","journal-title":"Sci. World J."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shu, Y., Jiang, L., Liu, F., and Lv, G. (2022). Effects of Plant Diversity and Abiotic Factors on the Multifunctionality of an Arid Desert Ecosystem. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0266320"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s44372-025-00268-3","article-title":"Desert Aridity Recruits Xerophyte Microbiota of Diverse Structure and Function","volume":"2","author":"Hamza","year":"2025","journal-title":"Discov. Plants"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jobm.201900471","article-title":"Diversity of Arbuscular Mycorrhizal Fungi Associated with Acacia Trees in Southwestern Saudi Arabia","volume":"60","author":"Mahdhi","year":"2020","journal-title":"J. Basic Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/187152809788681029","article-title":"Mechanism of Action of Flavonoids as Anti-Inflammatory Agents: A Review","volume":"8","author":"Rathee","year":"2009","journal-title":"Inflamm. Allergy Drug Targets"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e20345","DOI":"10.1590\/s2175-97902022e20345","article-title":"Approach of Utilizing Artemisia Herbs to Treat Covid-19","volume":"58","author":"Badraoui","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Rahhal, B.M., Jaradat, N., Hawash, M., Qadi, M., Issa, L., Yahya, A., Sanyora, S., Saed, M., and Al-Rimawi, F. (2022). Phytochemical Screening, Antioxidative, Antiobesity, Antidiabetic and Antimicrobial Investigations of Artemisia scoparia Grown in Palestine. Processes, 10.","DOI":"10.3390\/pr10102050"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jep.2016.04.059","article-title":"Traditional Use of Medicinal Plants among Kalasha, Ismaeli and Sunni Groups in Chitral District, Khyber Pakhtunkhwa Province, Pakistan","volume":"188","author":"Sher","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jep.2013.05.035","article-title":"Indigenous Knowledge of Medicinal Plants from Gujranwala District, Pakistan","volume":"148","author":"Mahmood","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jep.2015.04.052","article-title":"Quantitative Ethnobotanical Survey of Medicinal Flora Thriving in Malakand Pass Hills, Khyber Pakhtunkhwa, Pakistan","volume":"169","author":"Barkatullah","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jep.2007.06.010","article-title":"Traditional Uses of Medicinal Plants among the Rural Communities of Churu District in the Thar Desert, India","volume":"113","author":"Parveen","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100256","DOI":"10.1016\/j.hermed.2019.100256","article-title":"Ethno-Survey of Traditional Use of Plants as Aphrodisiacs in Kashmir Himalaya, India","volume":"17\u201318","author":"Ganie","year":"2019","journal-title":"J. Herb. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13002-018-0229-4","article-title":"Quantitative Study of Medicinal Plants Used by the Communities Residing in Koh-e-Safaid Range, Northern Pakistani-Afghan Borders","volume":"14","author":"Hussain","year":"2018","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"890842","DOI":"10.1155\/2014\/890842","article-title":"A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine","volume":"2014","author":"Athar","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_50","first-page":"119","article-title":"The Essential Oil of Artemisia scoparia from Tajikistan Is Dominated by Phenyldiacetylenes","volume":"6","author":"Sharopov","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_51","first-page":"1113","article-title":"Medicinal Plants of Sewa River Catchment Area in the Northwest Himalaya and Its Implication for Conservation","volume":"9","author":"Khan","year":"2009","journal-title":"Ethnobot. Leafl."},{"key":"ref_52","unstructured":"Ligaa, U., and Tsembel, D. (2003). Medicinal Plants of Mongolia and Their Use in Traditional Medicine. Mongolia Today, Routledge."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13002-017-0172-9","article-title":"Medicinal Plants Used by Inhabitants of the Shigar Valley, Baltistan Region of Karakorum Range-Pakistan","volume":"13","author":"Abbas","year":"2017","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13002-017-0196-1","article-title":"Ethnopharmacological Studies of Indigenous Plants in Kel Village, Neelum Valley, Azad Kashmir, Pakistan","volume":"13","author":"Ahmad","year":"2017","journal-title":"J. Ethnobiol. Ethnomed."},{"key":"ref_55","first-page":"368572","article-title":"Ethnobotanical Study of Tehsil Kabal, Swat District, KPK, Pakistan","volume":"2011","author":"Ahmad","year":"2011","journal-title":"J. Bot."},{"key":"ref_56","first-page":"111","article-title":"Screening of Folk Remedies by Genus Artemisia Based on Ethnomedicinal Surveys and Traditional Knowledge of Native Communities of Pakistan","volume":"45","author":"Nadeem","year":"2013","journal-title":"Pak. J. Bot."},{"key":"ref_57","first-page":"43","article-title":"Ethnobotanical Studies on Some Useful Herbs of Haramosh and Bugrote Valleys in Gilgit, Northern Areas of Pakistan","volume":"40","author":"Khan","year":"2008","journal-title":"Pak. J. Bot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4314\/ajtcam.v3i2.31158","article-title":"Ethnopharmacology, Indigenous Collection and Preservation Techniques of Some Frequently Used Medicinal Plants of Utror and Gabral, District Swat, Pakistan","volume":"3","author":"Hamayun","year":"2006","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3923\/ajps.2006.646.653","article-title":"Ethnobotany of Medicinal Plants from Tian Mu Shan Biosphere Reserve, Zhejiang-Province, China","volume":"5","author":"Chaudhary","year":"2006","journal-title":"Asian J. Plant Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"110513","DOI":"10.1016\/j.biopha.2020.110513","article-title":"Recent Progress in the Study of Artemisiae scopariae Herba (Yin Chen), a Promising Medicinal Herb for Liver Diseases","volume":"130","author":"Cai","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_61","first-page":"9","article-title":"Ethnopharmacology of Some Important Medicinal Plants of Nanda Devi National Park, Uttarakhand, India","volume":"8","author":"Rana","year":"2010","journal-title":"Nat. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2478\/v10119-012-0028-z","article-title":"Traditional Knowledge on Ethnobotanical Uses of Plant Biodiversity: A Detailed Study from the Indian Western Himalaya","volume":"28","author":"Singh","year":"2012","journal-title":"Biodivers. Res. Conserv."},{"key":"ref_63","first-page":"2501","article-title":"Medicinal and Non-Medicinal Uses of Some Plants Found in the Middle Region of Saudi Arabia","volume":"7","author":"Youssef","year":"2013","journal-title":"J. Med. Plants Res."},{"key":"ref_64","first-page":"368","article-title":"Ethnobotanical Study of Medicinal Plants Used by Kurd Tribe in Dehloran and Abdanan Districts, Ilam Province, Iran","volume":"10","author":"Momeni","year":"2012","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_65","first-page":"64","article-title":"An Ethnobotanical Survey on Hormozgan Province, Iran","volume":"3","author":"Safa","year":"2013","journal-title":"Avicenna J. Phytomed."},{"key":"ref_66","first-page":"92","article-title":"Artemisia scoparia: A Review on Traditional Uses, Phytochemistry and Pharmacological Properties","volume":"12","author":"Boakye","year":"2017","journal-title":"Int. J. Chem. Biochem. Sci."},{"key":"ref_67","unstructured":"Karimi, A.G. (2024). Traditional Use of Medicinal Plants in Afghanistan with Respect to the Kabul and Parwan Regions, Philipps-Universit\u00e4t Marburg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1177\/2156587214548458","article-title":"In Vitro Attenuation of Thermal-Induced Protein Denaturation by Aerial Parts of Artemisia scoparia","volume":"20","author":"Khan","year":"2015","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0254-6272(14)60038-8","article-title":"Effect of Artemisia Species on Cellular Proliferation and Apoptosis in Human Breast Cancer Cells via Estrogen Receptor-Related Pathway","volume":"33","author":"Choi","year":"2013","journal-title":"J. Tradit. Chin. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0306-3623(93)90434-Y","article-title":"Protective Effect of Artemisia scoparia Extract against Acetaminophen-Induced Hepatotoxicity","volume":"24","author":"Gilani","year":"1993","journal-title":"Gen. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10068-017-0077-3","article-title":"Artemisia scoparia Attenuates Amyloid \u03b2 Accumulation and Tau Hyperphosphorylation in Spontaneously Hypertensive Rats","volume":"26","author":"Promyo","year":"2017","journal-title":"Food Sci. Biotechnol."},{"key":"ref_72","unstructured":"Chinese Pharmacopoeia Commission (2015). Pharmacopoeia of the People\u2019s Republic of China, China Medical Science Press. [10th ed.]."},{"key":"ref_73","unstructured":"Bensky, D., Clavey, S., and St\u00f6ger, E. (2015). Chinese Herbal Medicine: Materia Medica, Eastland Press. [3rd ed.]."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/2225-4110.106533","article-title":"Recent Studies and Progression of Yin Chen Hao (Y\u012bn Ch\u00e9n H\u0101o), a Long-Term Used Traditional Chinese Medicine","volume":"3","author":"Hung","year":"2013","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0014-2999(92)90155-W","article-title":"Vasodilator Effect of Scoparone (6,7-Dimethoxycoumarin) from a Chinese Herb","volume":"218","author":"Huang","year":"1992","journal-title":"Eur. J. Pharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1300\/J044v05n04_09","article-title":"New Compounds from Roots of Artemisia scoparia","volume":"5","author":"Sharma","year":"1998","journal-title":"J. Herbs Spices Med. Plants"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jphs.2018.05.006","article-title":"Scoparone Attenuates Angiotensin II-Induced Extracellular Matrix Remodeling in Cardiac Fibroblasts","volume":"137","author":"Fu","year":"2018","journal-title":"J. Pharmacol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"105797","DOI":"10.1016\/j.intimp.2019.105797","article-title":"Scoparone Alleviates Inflammation, Apoptosis and Fibrosis of Non-Alcoholic Steatohepatitis by Suppressing the TLR4\/NF-\u03baB Signaling Pathway in Mice","volume":"75","author":"Liu","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF02977716","article-title":"Scoparone from Artemisia Capillaris Inhibits the Release of Inflammatory Mediators in RAW 264.7 Cells upon Stimulation Cells by Interferon-Gamma Plus LPS","volume":"28","author":"Jang","year":"2005","journal-title":"Arch. Pharmacal Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.phymed.2013.09.001","article-title":"Antioxidant and Intestinal Anti-Inflammatory Effects of Plant-Derived Coumarin Derivatives","volume":"21","author":"Witaicenis","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-2999(91)90624-Y","article-title":"Vasorelaxants from Chinese Herbs, Emodin and Scoparone, Possess Immunosuppressive Properties","volume":"198","author":"Huang","year":"1991","journal-title":"Eur. J. Pharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.exppara.2012.11.025","article-title":"Different Susceptibilities of Leishmania spp. Promastigotes to the Annona muricata, acetogenins annonacinone and corossolone, and the Platymiscium floribundum Coumarin Scoparone","volume":"133","author":"Alcantara","year":"2013","journal-title":"Exp. Parasitol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0165-022X(89)90039-0","article-title":"The Scopoletin Assay for Hydrogen Peroxide. A Review and a Better Method","volume":"18","author":"Corbett","year":"1989","journal-title":"J. Biochem. Biophys. Methods"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ptr.2890","article-title":"Antioxidant Activities of Coumarins from Korean Medicinal Plants and Their Structure-Activity Relationships","volume":"24","author":"Thuong","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/np960422f","article-title":"Antiinflammatory Activity of Coumarins from Santolina oblongifolia","volume":"59","author":"Abad","year":"1996","journal-title":"J. Nat. Prod."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ejphar.2010.06.043","article-title":"Antidepressant-like Effect of Scopoletin, a Coumarin Isolated from Polygala sabulosa (Polygalaceae) in Mice: Evidence for the Involvement of Monoaminergic Systems","volume":"643","author":"Capra","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jep.2010.01.042","article-title":"Anticonvulsant Activity of Benkara malabarica (Linn.) Root Extract: In Vitro and in Vivo Investigation","volume":"128","author":"Mishra","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.3390\/molecules20022786","article-title":"Scopoletin Protects against Methylglyoxal-Induced Hyperglycemia and Insulin Resistance Mediated by Suppression of Advanced Glycation Endproducts (AGEs) Generation and Anti-Glycation","volume":"20","author":"Chang","year":"2015","journal-title":"Molecules"},{"key":"ref_89","first-page":"3190","article-title":"Anticancer Natural Coumarins as Lead Compounds for the Discovery of New Drugs","volume":"17","author":"Pinto","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6080597","DOI":"10.1155\/2020\/6080597","article-title":"Oral Administration of Quercetin or Its Derivatives Inhibit Bone Loss in Animal Model of Osteoporosis","volume":"2020","author":"Huang","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1021\/np300824h","article-title":"Scopoletin and Scopolin Isolated from Artemisia iwayomogi Suppress Differentiation of Osteoclastic Macrophage RAW 264.7 Cells by Scavenging Reactive Oxygen Species","volume":"76","author":"Lee","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jep.2012.04.044","article-title":"Gastrokinetic Activity of Morinda Citrifolia Aqueous Fruit Extract and Its Possible Mechanism of Action in Human and Rat Models","volume":"142","author":"Nima","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1021\/jf053071w","article-title":"Antifungal and Antibacterial Activities of Mexican Tarragon (Tagetes lucida)","volume":"54","author":"Avila","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.2174\/1381612043382710","article-title":"Natural and Synthetic Coumarin Derivatives with Anti-Inflammatory\/ Antioxidant Activities","volume":"10","author":"Fylaktakidou","year":"2004","journal-title":"Curr. Pharm. Des."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/10412905.2020.1750495","article-title":"Chemical Composition of the Essential Oils of Artemisia Species from Iran: A Comparative Study Using Multivariate Statistical Analysis","volume":"32","author":"Ranjbar","year":"2020","journal-title":"J. Essent. Oil Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1021\/np50081a012","article-title":"Isolation of Potential Cancer Chemopreventive Agents from Eriodictyon californicum","volume":"55","author":"Liu","year":"1992","journal-title":"J. Nat. Prod."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6644253","DOI":"10.1155\/2020\/6644253","article-title":"Identification of Bioactive Components from Ruellia tuberosa L. on Improving Glucose Uptake in TNF-\u03b1-Induced Insulin-Resistant Mouse FL83B Hepatocytes","volume":"2020","author":"Xu","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/ptr.3635","article-title":"The Role of Capillarisin from Artemisia capillaris on Penile Erection","volume":"26","author":"Kim","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuint.2017.01.018","article-title":"Capillarisin Augments Anti-Oxidative and Anti-Inflammatory Responses by Activating Nrf2\/HO-1 Signaling","volume":"105","author":"Kim","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_100","first-page":"1907","article-title":"Capillarisin Exerts Antiasthmatic Activity in Neonatal Rats via Modulating the Matrix Remodeling","volume":"33","author":"Peng","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.canlet.2013.12.008","article-title":"Capillarisin Inhibits Constitutive and Inducible STAT3 Activation through Induction of SHP-1 and SHP-2 Tyrosine Phosphatases","volume":"345","author":"Lee","year":"2014","journal-title":"Cancer Lett."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/08923973.2017.1405438","article-title":"Anti-Inflammatory Effects of Artemisia scoparia and Its Active Constituent, 3,5-Dicaffeoyl-Epi-Quinic Acid against Activated Mast Cells","volume":"40","author":"Nam","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s11418-013-0799-3","article-title":"Inhibitory Effect of Chemical Constituents from Artemisia scoparia Waldst. et Kit. on Triglyceride Accumulation in 3T3-L1 Cells and Nitric Oxide Production in RAW 264.7 Cells","volume":"68","author":"Yahagi","year":"2014","journal-title":"J. Nat. Med."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Boudreau, A., Poulev, A., Ribnicky, D.M., Raskin, I., Rathinasabapathy, T., Richard, A.J., and Stephens, J.M. (2019). Distinct Fractions of an Artemisia scoparia Extract Contain Compounds With Novel Adipogenic Bioactivity. Front. Nutr., 6.","DOI":"10.3389\/fnut.2019.00018"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2015.10.032","article-title":"Three New Anti-HBV Active Constituents from the Traditional Chinese Herb of Yin-Chen (Artemisia scoparia)","volume":"176","author":"Geng","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3329\/bjp.v5i1.4901","article-title":"Artemisia scoparia: A New Source of Artemisinin","volume":"5","author":"Singh","year":"2010","journal-title":"Bangladesh J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.lwt.2010.05.033","article-title":"Fatty Acids Profile of Selected Artemisia Spp. Plants: Health Promotion","volume":"44","author":"Carvalho","year":"2011","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"495","DOI":"10.15835\/nsb749683","article-title":"Phytochemical Contents of Five Artemisia Species","volume":"7","author":"Kursat","year":"2015","journal-title":"Not. Sci. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0305-1978(02)00178-3","article-title":"Exudate Flavonoids in Species of Artemisia (Asteraceae\u2014Anthemideae): New Results and Chemosystematic Interpretation","volume":"31","author":"Fischer","year":"2003","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.foodchem.2007.04.038","article-title":"Antioxidant Activity and Phenolic Compounds in 32 Selected Herbs","volume":"105","author":"Czemerys","year":"2007","journal-title":"Food Chem."},{"key":"ref_111","first-page":"1","article-title":"Chemical Constituents and Biological Activities of Artemisia Herba-Alba","volume":"4","author":"Mohamed","year":"2010","journal-title":"Rec. Nat. Prod."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s10600-010-9473-0","article-title":"Component Composition of Essential Oil from Artemisia annua and A. scoparia","volume":"45","author":"Khodakov","year":"2009","journal-title":"Chem. Nat. Compd."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.indcrop.2010.03.007","article-title":"Phytotoxic Effects of Volatile Oil from Artemisia scoparia against Weeds and Its Possible Use as a Bioherbicide","volume":"32","author":"Kaur","year":"2010","journal-title":"Ind. Crops Prod."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02234877","article-title":"Essential Oils of Some Artemisia Species from Central Asia","volume":"33","author":"Basher","year":"1997","journal-title":"Chem. Nat. Compd."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.fct.2010.01.017","article-title":"In Vitro Screening of Essential Oil from Young and Mature Leaves of Artemisia scoparia Compared to Its Major Constituents for Free Radical Scavenging Activity","volume":"48","author":"Singh","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1016\/j.arabjc.2020.09.055","article-title":"Chemical Composition and Antimicrobial Activity of the Essential Oils of Artemisia absinthium, Artemisia scoparia, and Artemisia sieberi Grown in Saudi Arabia","volume":"13","author":"Aati","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_117","first-page":"254","article-title":"Essential Oil Compositions of Artemisia scoparia Waldst. et. Kit Native to North East of Iran","volume":"4","author":"Danesh","year":"2010","journal-title":"Adv. Environ. Biol."},{"key":"ref_118","first-page":"44","article-title":"In Vitro Anti-Leishmanial Activity Against Cutaneous leishmania Parasites and Preliminary Phytochemical Analysis of Four Yemeni Medicinal Plants","volume":"3","author":"Hajj","year":"2018","journal-title":"Univers. J. Pharm. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1055\/a-1345-9528","article-title":"Artemisia annua\u2014Importance in Traditional Medicine and Current State of Knowledge on the Chemistry, Biological Activity and Possible Applications","volume":"87","author":"Ekiert","year":"2021","journal-title":"Planta Med."},{"key":"ref_120","first-page":"479","article-title":"Comparative Phytochemical Study of Artemisia Sp. in the Middle East: A Focus on Antimicrobial Activities and GC-MS Analysis in A. absinthium L. Jazan, KSA and A. Herba-Alba Asso Sinai, EGY","volume":"13","author":"Mashraqi","year":"2024","journal-title":"J. Med. Plants By-Prod."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kim, J.-K., Kim, J.-Y., Kim, H.-J., Park, K.-G., Harris, R.A., Cho, W.-J., Lee, J.-T., and Lee, I.-K. (2013). Scoparone Exerts Anti-Tumor Activity against DU145 Prostate Cancer Cells via Inhibition of STAT3 Activity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0080391"},{"key":"ref_122","first-page":"4","article-title":"Effect of Artemisia Capillaris Thunb, Radix Paeonia Rabrae, Spargrnium Stoloniferum Buch-Hum and Epimedium Brevicornum Maxim on Regression of Atherosclevosis and Expression of Oncogenes in Experimental Rabbiets","volume":"18","author":"Yu","year":"2001","journal-title":"J. Hubei Univ. Nation."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2017.03.042","article-title":"Metformin-like Antidiabetic, Cardio-Protective and Non-Glycemic Effects of Naringenin: Molecular and Pharmacological Insights","volume":"803","author":"Nyane","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev-nutr-071715-050718","article-title":"Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis","volume":"36","author":"Mulvihill","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jep.2008.02.012","article-title":"Anticomplementary Principles of a Chinese Multiherb Remedy for the Treatment and Prevention of SARS","volume":"117","author":"Zhang","year":"2008","journal-title":"J. Ethnopharmacol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Khan, F.A., Khan, N.M., Ahmad, S., Aziz, R., Ullah, I., Almehmadi, M., Allahyani, M., Alsaiari, A.A., and Aljuaid, A. (2022). Phytochemical Profiling, Antioxidant, Antimicrobial and Cholinesterase Inhibitory Effects of Essential Oils Isolated from the Leaves of Artemisia scoparia and Artemisia absinthium. Pharmaceuticals, 15.","DOI":"10.3390\/ph15101221"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.3923\/pjbs.2006.1979.1982","article-title":"Composition and Antifungal Activity of Essential Oil of Artemisia sieberi Bess. on Soil-Borne Phytopathogens","volume":"9","author":"Farzaneh","year":"2006","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_128","first-page":"375","article-title":"Anti-Cancer Effects of Biosynthesized Zinc Oxide Nanoparticles Using Artemisia scoparia in Huh-7 Liver Cancer Cells","volume":"52","author":"Tafvizi","year":"2022","journal-title":"Inorg. Nano-Met. Chem."},{"key":"ref_129","first-page":"353","article-title":"Preliminary Screening of Methanolic Plant Extracts Against Human Rhabdomyosarcoma Cell Line from Salt Range, Pakistan","volume":"47","author":"Maqsood","year":"2015","journal-title":"Pak. J. Bot."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.lfs.2006.06.045","article-title":"Comparative Immunomodulatory Effect of Scopoletin on Tumoral and Normal Lymphocytes","volume":"79","author":"Manuele","year":"2006","journal-title":"Life Sci."},{"key":"ref_131","first-page":"997","article-title":"Scopoletin Exerts Anticancer Effects on Human Cervical Cancer Cell Lines by Triggering Apoptosis, Cell Cycle Arrest, Inhibition of Cell Invasion and PI3K\/AKT Signalling Pathway","volume":"24","author":"Tian","year":"2019","journal-title":"J. BUON"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mvr.2016.04.009","article-title":"Scopoletin, an Active Principle of Tree Tobacco (Nicotiana glauca) Inhibits Human Tumor Vascularization in Xenograft Models and Modulates ERK1, VEGF-A, and FGF-2 in Computer Model","volume":"107","author":"Tabana","year":"2016","journal-title":"Microvasc. Res."},{"key":"ref_133","first-page":"487","article-title":"Antibacterial and Anticancer Activities of Silver Nanoparticles Fabricated by the Artemisia scoparia Extract against Lung Cancer Cell Line (A549)","volume":"22","author":"Moulaie","year":"2018","journal-title":"J. Kashan Univ. Med. Sci."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"112790","DOI":"10.1016\/j.indcrop.2020.112790","article-title":"Encapsulation of Artemisia scoparia Extract in Chitosan-Myristate Nanogel with Enhanced Cytotoxicity and Apoptosis against Hepatocellular Carcinoma Cell Line (Huh-7)","volume":"155","author":"Haghighi","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/jcph.755","article-title":"Artemisia Extract Improves Insulin Sensitivity in Women with Gestational Diabetes Mellitus by Up-Regulating Adiponectin","volume":"56","author":"Sun","year":"2016","journal-title":"J. Clin. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"116933","DOI":"10.1016\/j.lfs.2019.116933","article-title":"Beyond Its Antioxidant Properties: Quercetin Targets Multiple Signalling Pathways in Hepatocellular Carcinoma in Rats","volume":"236","author":"Salama","year":"2019","journal-title":"Life Sci."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Shi, H., Li, X.-Y., Chen, Y., Zhang, X., Wu, Y., Wang, Z.-X., Chen, P.-H., Dai, H.-Q., Feng, J., and Chatterjee, S. (2020). Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor\/Akt Signaling Pathway in Acute Myeloid Leukemia Cells. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.534171"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1021\/jf060123o","article-title":"Chemical Composition of the Essential Oils of Serbian Wild-Growing Artemisia absinthium and Artemisia vulgaris","volume":"54","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.foodchem.2012.10.102","article-title":"Chemical Composition, Antimicrobial, Cytotoxic and Antioxidant Activities of the Essential Oil of Artemisia indica Willd","volume":"138","author":"Rashid","year":"2013","journal-title":"Food Chem."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4103\/0974-8490.210329","article-title":"Investigation of Effect of 1,8-Cineole on Antimicrobial Activity of Chlorhexidine Gluconate","volume":"9","author":"Duman","year":"2017","journal-title":"Pharmacogn. Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.fitote.2003.11.006","article-title":"Antimicrobial Activity of Four Artemisia Species of Iran","volume":"75","author":"Ramezani","year":"2004","journal-title":"Fitoterapia"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Stojanovi\u0107, G.S., Ickovski, J.D., \u0110or\u0111evi\u0107, A.S., Petrovi\u0107, G.M., Stepi\u0107, K.D., Pali\u0107, I.R., and Stamenkovi\u0107, J.G. (2020). The First Report on Chemical Composition and Antimicrobial Activity of Artemisia scoparia Waldst. et Kit. Extracts. Nat. Prod. Commun., 15.","DOI":"10.1177\/1934578X20915034"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1002\/oby.22912","article-title":"Mechanisms of Artemisia scoparia\u2019s Anti-Inflammatory Activity in Cultured Adipocytes, Macrophages, and Pancreatic \u03b2-Cells","volume":"28","author":"Boudreau","year":"2020","journal-title":"Obesity"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.nut.2014.02.013","article-title":"Artemisia Extracts Activate PPAR\u03b3, Promote Adipogenesis, and Enhance Insulin Sensitivity in Adipose Tissue of Obese Mice","volume":"30","author":"Richard","year":"2014","journal-title":"Nutrition"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Richard, A.J., Fuller, S., Fedorcenco, V., Beyl, R., Burris, T.P., Mynatt, R., Ribnicky, D.M., and Stephens, J.M. (2014). Artemisia scoparia Enhances Adipocyte Development and Endocrine Function In Vitro and Enhances Insulin Action In Vivo. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0098897"},{"key":"ref_146","first-page":"235","article-title":"Anti-Oxidant Activities and Anti-Inflammatory Effects on Artemisia scoparia","volume":"37","author":"Yoon","year":"2007","journal-title":"Korean Soc. Pharmacogn."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"113606","DOI":"10.1016\/j.jep.2020.113606","article-title":"Water Extract of Artemisia scoparia Waldst. & Kitam Suppresses LPS-Induced Cytokine Production and NLRP3 Inflammasome Activation in Macrophages and Alleviates Carrageenan-Induced Acute Inflammation in Mice","volume":"268","author":"Ahn","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/ced.13565","article-title":"Therapeutic Effects of Artemisia scoparia Waldst. et Kitaib in a Murine Model of Atopic Dermatitis","volume":"43","author":"Ryu","year":"2018","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.intimp.2013.10.011","article-title":"Scopoletin Suppresses IL-6 Production from Fibroblast-like Synoviocytes of Adjuvant Arthritis Rats Induced by IL-1\u03b2 Stimulation","volume":"17","author":"Dou","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1472-8206.2009.00784.x","article-title":"Anti-Arthritic Effect of Scopoletin, a Coumarin Compound Occurring in Erycibe Obtusifolia Benth Stems, Is Associated with Decreased Angiogenesis in Synovium","volume":"24","author":"Pan","year":"2010","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fitote.2003.12.021","article-title":"Scopoletin Suppresses Pro-Inflammatory Cytokines and PGE2 from LPS-Stimulated Cell Line, RAW 264.7 Cells","volume":"75","author":"Kim","year":"2004","journal-title":"Fitoterapia"},{"key":"ref_152","first-page":"404","article-title":"Inhibitory Effect of Scoparone on Airway Inflammation and Enhanced ROS of Asthmatic Models of Guinea Pigs","volume":"31","author":"Yuan","year":"2002","journal-title":"J. China Med. Univ."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"231","DOI":"10.21037\/atm.2020.01.31","article-title":"Yin Zhi Huang, a Traditional Chinese Herbal Formula, Ameliorates Diet-Induced Obesity and Hepatic Steatosis by Activating the AMPK\/SREBP-1 and the AMPK\/ACC\/CPT1A Pathways","volume":"8","author":"Yao","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0006-2952(82)90440-3","article-title":"Specificity of a Phenobarbital-Induced Cytochrome P-450 for Metabolism of Carbon Tetrachloride to the Trichloromethyl Radical","volume":"31","author":"Noguchi","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0367-326X(02)00217-4","article-title":"Protective Effect of Rutin on Paracetamol- and CCl4-Induced Hepatotoxicity in Rodents","volume":"73","author":"Janbaz","year":"2002","journal-title":"Fitoterapia"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s40618-014-0096-3","article-title":"Review of the Protective Effects of Rutin on the Metabolic Function as an Important Dietary Flavonoid","volume":"37","author":"Hosseinzadeh","year":"2014","journal-title":"J. Endocrinol. Investig."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.biopha.2018.08.046","article-title":"Protective Effects of Rutin on Liver Injury in Type 2 Diabetic Db\/Db Mice","volume":"107","author":"Liang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF02861907","article-title":"Effect of Scoparone on the Hepatic Microsomal UDP Glucuronyltransferase Activity in Mice","volume":"10","author":"Huh","year":"1987","journal-title":"Arch. Pharmacal Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"109895","DOI":"10.1016\/j.biopha.2020.109895","article-title":"Scoparone Improves Hepatic Inflammation and Autophagy in Mice with Nonalcoholic Steatohepatitis by Regulating the ROS\/P38\/Nrf2 Axis and PI3K\/AKT\/mTOR Pathway in Macrophages","volume":"125","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.metabol.2013.03.004","article-title":"Artemisia scoparia Extract Attenuates Non-Alcoholic Fatty Liver Disease in Diet-Induced Obesity Mice by Enhancing Hepatic Insulin and AMPK Signaling Independently of FGF21 Pathway","volume":"62","author":"Wang","year":"2013","journal-title":"Metabolism"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1080\/03639045.2020.1811302","article-title":"Antihyperuricemic Efficacy of Scopoletin-Loaded Soluplus Micelles in Yeast Extract\/Potassium Oxonate-Induced Hyperuricemic Mice","volume":"46","author":"Zeng","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1055\/s-2005-837789","article-title":"Hypouricemic Action of Scopoletin Arising from Xanthine Oxidase Inhibition and Uricosuric Activity","volume":"71","author":"Ding","year":"2005","journal-title":"Planta Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.etp.2010.02.006","article-title":"Protective Effects of Coumarin and Coumarin Derivatives against Carbon Tetrachloride-Induced Acute Hepatotoxicity in Rats","volume":"63","author":"Bilgin","year":"2011","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/0960327116649675","article-title":"Influence of Coumarin and Some Coumarin Derivatives on Serum Lipid Profiles in Carbontetrachloride-Exposed Rats","volume":"36","author":"Atmaca","year":"2017","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"110301","DOI":"10.1016\/j.biopha.2020.110301","article-title":"Isorhamnetin: A Review of Pharmacological Effects","volume":"128","author":"Gong","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"8765954","DOI":"10.1155\/2019\/8765954","article-title":"SIRT1 Modulators in Experimentally Induced Liver Injury","volume":"2019","author":"Farghali","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2017.11.003","article-title":"Food Components with Antifibrotic Activity and Implications in Prevention of Liver Disease","volume":"55","author":"Bae","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3748\/wjg.v24.i16.1679","article-title":"Beneficial Effects of Naringenin in Liver Diseases: Molecular Mechanisms","volume":"24","author":"Muriel","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1089\/jmf.2005.8.348","article-title":"In Vivo Antihepatotoxic Effects of Ligularia fischeri Var. Spiciformis and the Identification of the Active Component, 3,4-Dicaffeoylquinic Acid","volume":"8","author":"Choi","year":"2005","journal-title":"J. Med. Food"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1002\/ptr.6781","article-title":"Naringenin, a Flavanone with Antiviral and Anti-Inflammatory Effects: A Promising Treatment Strategy against COVID-19","volume":"34","author":"Tutunchi","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_171","first-page":"1452","article-title":"Study on the Effect of Total Flavonoids Extracted from Artemisa scoparia on Anti-Influenzavirus","volume":"27","author":"Huang","year":"2012","journal-title":"Chin. J. Tradit. Chin. Med. Pharm."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12985-018-0995-6","article-title":"Cirsimaritin Inhibits Influenza A Virus Replication by Downregulating the NF-\u03baB Signal Transduction Pathway","volume":"15","author":"Yan","year":"2018","journal-title":"Virol. J."},{"key":"ref_173","first-page":"75","article-title":"Antimicrobial and Antioxidant Properties of Artemisia L. Species from Western Anatolia","volume":"36","author":"Erel","year":"2012","journal-title":"Turk. J. Biol."},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Sajid, M., Khan, M.R., Shah, N.A., Ullah, S., Younis, T., Majid, M., Ahmad, B., and Nigussie, D. (2016). Proficiencies of Artemisia scoparia against CCl4 Induced DNA Damages and Renal Toxicity in Rat. BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1137-6"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1590\/S0102-695X2011005000144","article-title":"Evaluation of Antimalarial, Free-Radical-Scavenging and Insecticidal Activities of Artemisia scoparia and A. spicigera, Asteraceae","volume":"21","author":"Afshar","year":"2011","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/znc-2007-1-211","article-title":"Scoparone Inhibits Ultraviolet Radiation-Induced Lipid Peroxidation","volume":"62","author":"Sourivong","year":"2007","journal-title":"Z. F\u00fcr Naturforschung C"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Kaurinovic, B., and Vastag, D. (2019). Flavonoids and Phenolic Acids as Potential Natural Antioxidants. Antioxidants, IntechOpen.","DOI":"10.5772\/intechopen.83731"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/S1466252317000081","article-title":"Rosmarinic Acid: Modes of Action, Medicinal Values and Health Benefits","volume":"18","author":"Alagawany","year":"2017","journal-title":"Anim. Health Res. Rev."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"E1053","DOI":"10.1152\/ajpendo.00177.2018","article-title":"An Ethanolic Extract of Artemisia scoparia Inhibits Lipolysis in Vivo and Has Antilipolytic Effects on Murine Adipocytes in Vitro","volume":"315","author":"Boudreau","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/oby.23199","article-title":"Artemisia scoparia Promotes Adipogenesis in the Absence of Adipogenic Effectors","volume":"29","author":"Harvey","year":"2021","journal-title":"Obesity"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.ejphar.2018.07.032","article-title":"Scopoletin Inhibits \u03b1-Glucosidase in Vitro and Alleviates Postprandial Hyperglycemia in Mice with Diabetes","volume":"834","author":"Jang","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/ptr.5925","article-title":"Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice","volume":"31","author":"Choi","year":"2017","journal-title":"Phytother. Res."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nutres.2019.12.003","article-title":"Scopoletin Increases Glucose Uptake through Activation of PI3K and AMPK Signaling Pathway and Improves Insulin Sensitivity in 3T3-L1 Cells","volume":"74","author":"Jang","year":"2020","journal-title":"Nutr. Res."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.foodchem.2013.04.036","article-title":"Scoparone Inhibits Adipocyte Differentiation through Down-Regulation of Peroxisome Proliferators-Activated Receptor \u03b3 in 3T3-L1 Preadipocytes","volume":"141","author":"Noh","year":"2013","journal-title":"Food Chem."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3746\/pnf.2019.24.3.299","article-title":"Artemisia Princeps Inhibits Adipogenic Differentiation of 3T3-L1 Pre-Adipocytes via Downregulation of PPAR\u03b3 and MAPK Pathways","volume":"24","author":"Oh","year":"2019","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"6248","DOI":"10.1021\/jm049655r","article-title":"Acetylcholinesterase Inhibitory Activity of Scopolin and Scopoletin Discovered by Virtual Screening of Natural Products","volume":"47","author":"Rollinger","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2633105520937693.","DOI":"10.1177\/2633105520937693","article-title":"Scopoletin: Antiamyloidogenic, Anticholinesterase, and Neuroprotective Potential of a Natural Compound Present in Argyreia speciosa Roots by In Vitro and In Silico Study","volume":"15","author":"Kashyap","year":"2020","journal-title":"Neurosci. Insights"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.biopha.2017.09.127","article-title":"Therapeutic Effects of Scoparone on Pilocarpine (Pilo)-Induced Seizures in Mice","volume":"97","author":"Xia","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1021\/np0100946","article-title":"Coumarins with Monoamine Oxidase Inhibitory Activity and Antioxidative Coumarino-Lignans from Hibiscus syriacus","volume":"64","author":"Yun","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2011.09.006","article-title":"The Coumarin Scopoletin Potentiates Acetylcholine Release from Synaptosomes, Amplifies Hippocampal Long-Term Potentiation and Ameliorates Anticholinergic- and Age-Impaired Memory","volume":"197","author":"Hornick","year":"2011","journal-title":"Neuroscience"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13041-020-0560-2","article-title":"Scopoletin Ameliorates Anxiety-like Behaviors in Complete Freund\u2019s Adjuvant-Induced Mouse Model","volume":"13","author":"Luo","year":"2020","journal-title":"Mol. Brain"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.4103\/0973-1296.166065","article-title":"Neuroprotective Compounds of Tilia amurensis","volume":"11","author":"Lee","year":"2015","journal-title":"Pharmacogn. Mag."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Cho, D.-Y., Ko, H.M., Kim, J., Kim, B.-W., Yun, Y.-S., Park, J.-I., Ganesan, P., Lee, J.-T., and Choi, D.-K. (2016). Scoparone Inhibits LPS-Simulated Inflammatory Response by Suppressing IRF3 and ERK in BV-2 Microglial Cells. Molecules, 21.","DOI":"10.3390\/molecules21121718"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.apjtm.2016.01.014","article-title":"Anti-Alzheimer\u2019s Disease Potential of Coumarins from Angelica decursiva and Artemisia capillaris and Structure-Activity Analysis","volume":"9","author":"Ali","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"259","DOI":"10.5625\/lar.2011.27.3.259","article-title":"Esculetin Inhibits N-Methyl-D-Aspartate Neurotoxicity via Glutathione Preservation in Primary Cortical Cultures","volume":"27","author":"Lee","year":"2011","journal-title":"Lab. Anim. Res."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Liang, N., and Kitts, D.D. (2015). Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients, 8.","DOI":"10.3390\/nu8010016"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"19789","DOI":"10.3390\/molecules201119657","article-title":"Antihypertensive Effects of Artemisia scoparia Waldst in Spontaneously Hypertensive Rats and Identification of Angiotensin I Converting Enzyme Inhibitors","volume":"20","author":"Cho","year":"2015","journal-title":"Molecules"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1248\/cpb.43.1385","article-title":"Search for Naturally Occurring Substances to Prevent the Complications of Diabetes. II. Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation","volume":"43","author":"Okada","year":"1995","journal-title":"Chem. Pharm. Bull."},{"key":"ref_200","first-page":"527","article-title":"Effect of Scopoletin on Lipoprotein Lipase Activity in 3T3-L1 Adipocytes","volume":"20","author":"Yang","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.biopha.2017.09.067","article-title":"Esculetin Ameliorates Vascular Perturbation by Intervening in the Occupancy of H2BK120Ub at At1, At2, Tgf\u03b21 and Mcp1 Promoter Gene in Thoracic Aorta of IR and T2D Rats","volume":"95","author":"Kadakol","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/S0006-2952(03)00161-8","article-title":"Esculetin Inhibits Ras-Mediated Cell Proliferation and Attenuates Vascular Restenosis Following Angioplasty in Rats","volume":"65","author":"Pan","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"106217","DOI":"10.1016\/j.intimp.2020.106217","article-title":"Hyperlipidemia-Induced Lipotoxicity and Immune Activation in Rats Are Prevented by Curcumin and Rutin","volume":"81","author":"Manzoni","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"225","DOI":"10.31083\/j.rcm.2020.02.49","article-title":"Implication of Dietary Phenolic Acids on Inflammation in Cardiovascular Disease","volume":"21","author":"Ali","year":"2020","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Silva, H., and Lopes, N.M.F. (2020). Cardiovascular Effects of Caffeic Acid and Its Derivatives: A Comprehensive Review. Front. Physiol., 11.","DOI":"10.3389\/fphys.2020.595516"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"022015","DOI":"10.1088\/1755-1315\/1262\/2\/022015","article-title":"Effect of Some Environmental Factors on the Distribution and Spread of Artemisia scoparia Waldst. et Kit. in Basrah Governorate","volume":"1262","author":"Tuaih","year":"2023","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_207","first-page":"538940","article-title":"Essential Oil of Common Sage (Salvia officinalis L.) from Jordan: Assessment of Safety in Mammalian Cells and Its Antifungal and Anti-Inflammatory Potential","volume":"2013","author":"Cabral","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/10412905.2006.12067114","article-title":"The Geographical Variation and Antimicrobial Activity of African Wormwood (Artemisia afra Jacq.) Essential Oil","volume":"18","author":"Viljoen","year":"2006","journal-title":"J. Essent. Oil Res."},{"key":"ref_209","first-page":"189","article-title":"The Study of the Anti-Inflammatory Activity of a Stomatological Gel Based on an Extract of Artemisia scoparia Waldst. et Kit","volume":"26","author":"Pozdnyakov","year":"2022","journal-title":"J. Res. Pharm."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"113777","DOI":"10.1016\/j.jep.2021.113777","article-title":"Pharmacological Activity and Flavonoids Constituents of Artemisia judaica L Aerial Parts","volume":"270","author":"Moharram","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_211","first-page":"102812","article-title":"Therapeutic Potential of Quercetin in Hepatocellular Carcinoma: Mechanisms, Challenges, and Clinical Insights","volume":"27","author":"Qadeer","year":"2026","journal-title":"J. Agric. Food Res."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.physbeh.2016.04.051","article-title":"Esculetin Attenuates Lipopolysaccharide (LPS)-Induced Neuroinflammatory Processes and Depressive-like Behavior in Mice","volume":"163","author":"Zhu","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Ekiert, H., Klimek-Szczykutowicz, M., Rzepiela, A., Klin, P., and Szopa, A. (2022). Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. Molecules, 27.","DOI":"10.3390\/molecules27196427"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Mohammed, H.A. (2022). Phytochemical Analysis, Antioxidant Potential, and Cytotoxicity Evaluation of Traditionally Used Artemisia absinthium L. (Wormwood) Growing in the Central Region of Saudi Arabia. Plants, 11.","DOI":"10.3390\/plants11081028"},{"key":"ref_215","first-page":"278","article-title":"Cytotoxic, Antimicrobial and Antioxidant Activities and Phytochemical Analysis of Artemisia judaica and A. sieberi in Saudi Arabia","volume":"14","author":"Nasr","year":"2020","journal-title":"AJPP"},{"key":"ref_216","unstructured":"Perry, L.M., and Metzger, J. (1980). Medicinal Plants of East and Southeast Asia: Attributed Properties and Uses, MIT Press."},{"key":"ref_217","doi-asserted-by":"crossref","unstructured":"Wang, L., Miao, Y., Wang, H., Hasimu, H., Ji, T., Huang, H., Du, G., Aisa, H.A., and Xin, X. (2026). Artemisia scoparia Extract Inhibits Oxidative Stress and Ferroptosis to Ameliorate MASH through AGE-RAGE and JAK1-STAT3 Signaling. Front. Pharmacol., 17.","DOI":"10.3389\/fphar.2026.1792221"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1002\/oby.70196","article-title":"An Artemisia scoparia Extract and Rosiglitazone Have Distinct but Overlapping Effects on Adipocyte Function","volume":"34","author":"Boudreau","year":"2026","journal-title":"Obesity"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.biopha.2018.07.062","article-title":"Scoparone Prevents IL-1\u03b2-Induced Inflammatory Response in Human Osteoarthritis Chondrocytes through the PI3K\/Akt\/NF-\u03baB Pathway","volume":"106","author":"Lu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Al-Khalaifah, H.S., and Al-Nasser, A.Y. (2024). Evaluating the Potential of Marine Algae as Sustainable Ingredients in Poultry Feed. Agriculture, 14.","DOI":"10.3390\/agriculture14111889"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"105795","DOI":"10.1016\/j.psj.2025.105795","article-title":"Mitigating Heat Stress in Broilers: Effects of Bacillus subtilis Probiotic and Garlic (Allium sativum) Supplementation on Growth Performance, Antioxidant Status, Cecal Microbiota and Immune Response","volume":"104","author":"Mushtaq","year":"2025","journal-title":"Poult. Sci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.14202\/vetworld.2024.1318-1327","article-title":"The Effects of Artemisia annua Nutritional Supplementation at Varying Concentrations on Broiler Growth, Economic Yield, and Gene Expression Levels of Certain Antioxidant, Inflammatory, and Immune Genes","volume":"17","author":"Mamdouh","year":"2024","journal-title":"Vet. World"},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3382\/ps.2012-02752","article-title":"Feeding Artemisia annua Alters Digesta pH and Muscle Lipid Oxidation Products in Broiler Chickens","volume":"92","author":"Cherian","year":"2013","journal-title":"Poult. Sci."},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Gouda, A., Al-Khalaifah, H., Al-Nasser, A., Kamel, N.N., Gabr, S., and Eid, K.M.A. (2024). Early Feeding Strategy Mitigates Major Physiological Dynamics Altered by Heat Stress in Broilers. Animals, 14.","DOI":"10.3390\/ani14101485"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"103594","DOI":"10.1016\/j.psj.2024.103594","article-title":"Effects of Dietary Artemisia annua Supplementation on Growth Performance, Antioxidant Capacity, Immune Function, and Gut Microbiota of Geese","volume":"103","author":"Cui","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_226","first-page":"22","article-title":"The Effect of Artemisia on Immune Response and Productive Performance Against Newcastle Disease in Broiler Chickens","volume":"12","author":"Kaab","year":"2022","journal-title":"J. World\u2019s Poult. Res."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"105","DOI":"10.31548\/animal.1.2024.105","article-title":"Effect of Feeding Artemisia capillaris on Egg Production and Egg Quality in Quail","volume":"15","author":"Sychov","year":"2024","journal-title":"Anim. Sci. Food Technol."},{"key":"ref_228","doi-asserted-by":"crossref","unstructured":"Al-Khalaifah, H., Al-Nasser, A., and Al-Surrayai, T. (2025). Investigating the Effect of Algal Inclusions in Broiler Chickens. Life, 15.","DOI":"10.3390\/life15040670"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Al-Khalaifah, H., and Uddin, S. (2022). Assessment of Sargassum sp., Spirulina sp., and Gracilaria sp. as Poultry Feed Supplements: Feasibility and Environmental Implications. Sustainability, 14.","DOI":"10.3390\/su14148968"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Al-Khalaifah, H., Al-Nasser, A., Al-Surrayai, T., Sultan, H., Al-Attal, D., Al-Kandari, R., Al-Saleem, H., Al-Holi, A., and Dashti, F. (2022). Effect of Ginger Powder on Production Performance, Antioxidant Status, Hematological Parameters, Digestibility, and Plasma Cholesterol Content in Broiler Chickens. Animals, 12.","DOI":"10.3390\/ani12070901"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.3382\/ps\/pey160","article-title":"Benefits of Probiotics and\/or Prebiotics for Antibiotic-Reduced Poultry","volume":"97","year":"2018","journal-title":"Poult. Sci."},{"key":"ref_232","doi-asserted-by":"crossref","unstructured":"Al-Khalaifah, H., Kamel, N.N., Gabr, S., and Gouda, A. (2025). The Synergistic Effect of Vitamin C Supplementation and Early Feed Withdrawal on Heat Stress Mitigation in Broiler Chickens. Animals, 15.","DOI":"10.3390\/ani15202996"},{"key":"ref_233","doi-asserted-by":"crossref","unstructured":"Ekor, M. (2014). The Growing Use of Herbal Medicines: Issues Relating to Adverse Reactions and Challenges in Monitoring Safety. Front. Pharmacol., 4.","DOI":"10.3389\/fphar.2013.00177"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1039\/C9NP00011A","article-title":"Synergy and Antagonism in Natural Product Extracts: When 1 + 1 Does Not Equal 2","volume":"36","author":"Caesar","year":"2019","journal-title":"Nat. Prod. Rep."},{"key":"ref_235","doi-asserted-by":"crossref","unstructured":"Trifan, A., Zengin, G., Sinan, K.I., Sieniawska, E., Sawicki, R., Maciejewska-Turska, M., Skalikca-Wo\u017aniak, K., and Luca, S.V. (2022). Unveiling the Phytochemical Profile and Biological Potential of Five Artemisia Species. Antioxidants, 11.","DOI":"10.3390\/antiox11051017"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s11418-016-1008-y","article-title":"Artemisinin-Based Antimalarial Research: Application of Biotechnology to the Production of Artemisinin, Its Mode of Action, and the Mechanism of Resistance of Plasmodium Parasites","volume":"70","author":"Muangphrom","year":"2016","journal-title":"J. Nat. Med."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"Batiha, G.E.-S., Olatunde, A., El-Mleeh, A., Hetta, H.F., Al-Rejaie, S., Alghamdi, S., Zahoor, M., Magdy Beshbishy, A., Murata, T., and Zaragoza-Bastida, A. (2020). Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Wormwood (Artemisia absinthium). Antibiotics, 9.","DOI":"10.3390\/antibiotics9060353"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Nikitin, E., Fitsev, I., Egorova, A., Logvinenko, L., Terenzhev, D., Bekmuratova, F., Rakhmaeva, A., Shumatbaev, G., Gatiyatullina, A., and Shevchuk, O. (2023). Five Different Artemisia L. Species Ethanol Extracts\u2019 Phytochemical Composition and Their Antimicrobial and Nematocide Activity. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814372"},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21273\/HORTSCI19534-26","article-title":"Comparative Assessment of Phytochemical Characteristics and Functional Bioactivities in Artemisia Species","volume":"61","author":"Kadi","year":"2026","journal-title":"HortScience"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7235\/HORT.20250081","article-title":"Optimization of Induction and Culture Strategies for Calli with Stem Cell-like Features for the Production of Functional Natural Products from Korean Native Plants: Case Studies Involving Artemisia, Ixeridium, and Perilla","volume":"44","author":"Lee","year":"2026","journal-title":"HST"},{"key":"ref_241","first-page":"2333","article-title":"Effects of Different Cutting System on Main Typical Steppe Populations in Inner Mongolia","volume":"16","author":"Bao","year":"2005","journal-title":"J. Appl. Ecol."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/aob\/mcac153","article-title":"Is a Seasonally Reduced Growth Potential a Convergent Strategy to Survive Drought and Frost in Plants?","volume":"131","author":"Volaire","year":"2023","journal-title":"Ann. Bot."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/00439339.2023.2239776","article-title":"Critical Review on the Use of Biochar in Poultry Industry: Benefits, Characteristics and Applications","volume":"79","year":"2023","journal-title":"World\u2019s Poult. Sci. J."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1515\/zpch-2022-0174","article-title":"Extraction and Characterization of Novel Cellulose Nanocrystals from Artemisia scoparia Straw and Their Application in Hydroxypropyl Methyl Cellulose (HPMC) Films","volume":"237","author":"Rehman","year":"2023","journal-title":"Z. F\u00fcr Phys. Chem."},{"key":"ref_245","doi-asserted-by":"crossref","unstructured":"Al-Khalaifah, H., and Al-Nasser, A. (2023, January 1). Using Native Plants in Poultry Feed: Food Security and Sustainability Approach. Proceedings of the 23rd SGEM International Multidisciplinary Scientific GeoConference, Albena, Bulgaria.","DOI":"10.5593\/sgem2023\/6.1\/s25.31"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"Alotaibi, M., and Al-Khalaifah, H.S. (2026). Potential of Solar Water Disinfection (SODIS) for Pathogen Control during Water Scarcity Crisis. Front. Water, 7.","DOI":"10.3389\/frwa.2025.1679793"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Klojdov\u00e1, I., Milota, T., Smetanov\u00e1, J., and Stathopoulos, C. (2023). Encapsulation: A Strategy to Deliver Therapeutics and Bioactive Compounds?. Pharmaceuticals, 16.","DOI":"10.3390\/ph16030362"},{"key":"ref_248","first-page":"224","article-title":"Encapsulation of Herbal Extracts in Biodegradable Polymers for Controlled Release","volume":"16","author":"Noth","year":"2024","journal-title":"J. Chem. Pharm. Res."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1002\/ece3.1770","article-title":"Plant\u2013Plant Interactions as a Mechanism Structuring Plant Diversity in a Mediterranean Semi-Arid Ecosystem","volume":"5","author":"Arroyo","year":"2015","journal-title":"Ecol. Evol."},{"key":"ref_250","doi-asserted-by":"crossref","unstructured":"Cosoveanu, A., and Cabrera, R. (2018). Endophytic Fungi in Species of Artemisia. J. Fungi, 4.","DOI":"10.3390\/jof4020053"},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Ricks, K.D., and Koide, R.T. (2019). The Role of Inoculum Dispersal and Plant Species Identity in the Assembly of Leaf Endophytic Fungal Communities. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219832"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"102","DOI":"10.5943\/mycosphere\/7\/2\/2","article-title":"Fungi as Endophytes in Chinese Artemisia spp.: Juxtaposed Elements of Phylogeny, Diversity and Bioactivity","volume":"7","author":"Cosoveanu","year":"2016","journal-title":"Mycosphere"},{"key":"ref_253","first-page":"83","article-title":"Isolation and Identification of Endophytic Fungi from Artemisia scoparia (Asteraceae)","volume":"10","author":"Nisa","year":"2018","journal-title":"Int. J. Theor. Appl. Sci."},{"key":"ref_254","first-page":"178","article-title":"Anti-Oxidative Responses to Soil Water Stress for Four Artemisia Species","volume":"38","author":"Wang","year":"2010","journal-title":"J. Northwest AF Univ. (Nat. Sci. Ed.)"},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/ece3.4909","article-title":"Seed Germination Responses to Seasonal Temperature and Drought Stress Are Species-Specific but Not Related to Seed Size in a Desert Steppe: Implications for Effect of Climate Change on Community Structure","volume":"9","author":"Yi","year":"2019","journal-title":"Ecol. Evol."},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/saj2.20229","article-title":"Effects of Arbuscular Mycorrhizal Fungi Symbiosis on Microbial Diversity and Enzyme Activities in the Rhizosphere Soil of Artemisia annua","volume":"85","author":"Ma","year":"2021","journal-title":"Soil Sci. Soc. Am. J."}],"container-title":["Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/17\/1466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T04:23:16Z","timestamp":1788063796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-7737\/15\/17\/1466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":256,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["biology15171466"],"URL":"https:\/\/doi.org\/10.3390\/biology15171466","relation":{},"ISSN":["2079-7737"],"issn-type":[{"value":"2079-7737","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}