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Baicalin (BA) is a flavonoid extracted from the dried roots of Scutellaria baicalensis and possesses a wide range of biological activity. In this study, 66 one-day-old white-feathered broilers were selected and randomly divided into two groups. Broilers in the control group were fed a basal diet, whereas the BA group received the basal diet supplemented with 100 mg\/kg BA. The results showed that BA supplementation markedly elevated the antioxidant capacity of the serum and liver (p &lt; 0.05). Meanwhile, the villus height\/crypt depth ratio and the activity of intestinal digestive enzymes were significantly higher in the BA group (p &lt; 0.01). Transcriptomics, RT-qPCR, and Western blot assays revealed that BA-mediated effects were associated with the hepatic PPAR\u03b1 signaling pathway and the regulation of lipid metabolism. Furthermore, a combined analysis encompassing intestinal microbiota 16S rRNA sequencing and plasma metabolomics revealed that the BA-induced enrichment of multiple bacterial taxa, such as Lachnospiraceae, may modulate butyrate metabolism and circulating metabolites including isoleucyl-glutamate in broilers. In conclusion, dietary BA supplementation improved the hepatic and intestinal health of white-feathered broilers, reshaped the intestinal microbiota composition, and altered the plasma metabolite profile, with these benefits linked to the PPAR\u03b1 signaling pathway.<\/jats:p>","DOI":"10.3390\/biology15181569","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:10:22Z","timestamp":1788855022000},"page":"1569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baicalin Modulates Hepatic Lipid Metabolism and Improves Intestinal Health in White-Feathered Broilers"],"prefix":"10.3390","volume":"15","author":[{"given":"Junxin","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Xiaowei","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yana","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yu","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Shizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou 350013, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Bohan","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Qinjin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Xiaohong","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province, Fujian Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health, Fujian Agriculture and Forestry University, Fuzhou 350002, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"visualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"given":"Zhaoyan","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China"},{"name":"University Key Laboratory for Integrated 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