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Yeasts are useful hosts for antioxidant production. This review distinguishes native yeast metabolites, cell-wall and extracellular components, heterologously synthesized antioxidant compounds, fermentation- or extraction-associated antioxidants, and antioxidants obtained from mixed cultures. This review examines how carbon-source type and membrane transport influence central-carbon metabolism, precursor availability, and NADPH supply. These processes can affect antioxidant biosynthesis, although the outcome depends on the substrate, yeast strain, and biosynthesis pathway. Finally, we summarize engineering strategies involving transporter optimization, carbon-flux redistribution, enhancement of precursor and cofactor supply, and regulation of stress responses. Integrating carbon uptake with intracellular metabolic allocation provides a mechanistic framework for understanding and improving antioxidant production in yeast.<\/jats:p>","DOI":"10.3390\/biology15181644","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:01:38Z","timestamp":1789981298000},"page":"1644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coupling Carbon-Source Transport with Antioxidant Biosynthesis in Yeast: Product Diversity and Engineering Strategies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4440-7756","authenticated-orcid":false,"given":"Mao-Dong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Yao","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, The University of Manchester, Oxford Rd., Manchester M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0190-6571","authenticated-orcid":false,"given":"Xin-Qing","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-6471","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai CHANDO Group Co., Ltd., Shanghai 200233, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1146\/annurev.biochem.77.061606.161055","article-title":"Cellular defenses against superoxide and hydrogen peroxide","volume":"77","author":"Imlay","year":"2008","journal-title":"Annu. 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